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The IUPHAR Guide to MALARIA PHARMACOLOGY ligand list

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Ligand name ID Synonyms
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ACT-451840 Antimalarial Ligand 10022 ACT451840, Actelion-451840
AIM-1290 Antimalarial Ligand 11823
albitiazolium Antimalarial Ligand 10407 SAR97276, SAR97276A, T3
altiratinib PDB Ligand Antimalarial Ligand 9174 DCC-270, DCC-2701, DP-5164
amodiaquine Approved drug PDB Ligand Antimalarial Ligand 10018 Alphaquine®, Amdaquine®, Amoquin®, Camoquin®, Flavoquine®
AN13762 Antimalarial Ligand 10085 AN762
AN3661 Antimalarial Ligand 10084
analog 18 [PMID: 28696697] Antimalarial Ligand 11567
apicidin Antimalarial Ligand 7495 OSI-2040
AQ-13 Antimalarial Ligand 10391 Ro 47-0543
artefenomel Antimalarial Ligand 9971 OZ439
arteflene Antimalarial Ligand 10397 Ro 42-1611
artemether Approved drug PDB Ligand Antimalarial Ligand 9955 β-artemether, beta-artemether
artemisinin Antimalarial Ligand 9954 qinghaosu
artemotil Antimalarial Ligand 9958 β-arteether
artenimol Approved drug Antimalarial Ligand 9957 DHA, dihydroartemisinin, GNF-Pf-5634
artesunate Approved drug PDB Ligand Antimalarial Ligand 9956
atovaquone Approved drug PDB Ligand Antimalarial Ligand 9695 566C80, Mepron®, Wellvone®
azithromycin Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6510
 
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BCH070 Antimalarial Ligand 10614
borrelidin Antimalarial Ligand 11306 (-)-borrelidin
bortezomib Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6391 peptide boronate, PS-341, Velcade®
BRD3444 Antimalarial Ligand 9648
BRD7929 PDB Ligand Antimalarial Ligand 11723
BRD9185 Antimalarial Ligand 11469 compound 27 [PMID: 28435533]
bulaquine Antimalarial Ligand 10414 CDRI-80/53, elubaquine
 
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CDRI-97/78 Antimalarial Ligand 10399
chloroquine Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 5535 Aralen®, chloraquine, Malaquin®
CHMFL-PI4K-127 Antimalarial Ligand 11285
cipargamin Antimalarial Ligand 9721 KAE609, NITD609
CIS43 Antimalarial Ligand 11254
CJ-15,801 Antimalarial Ligand 10610 CJ-15801
cladosporin PDB Ligand Antimalarial Ligand 10247 asperentin
clindamycin Approved drug PDB Ligand Antimalarial Ligand 10607
compound 14a [WO2021155612A1] Antimalarial Ligand 11958
compound 1a [WO2021204952A1] Antimalarial Ligand 11928
compound 11c [PMID: 30613327] PDB Ligand Antimalarial Ligand 11263
compound 34c [PMID: 24641010] PDB Ligand Antimalarial Ligand 9647
compound 49c [PMID: 29074775] Antimalarial Ligand 10418
compound 2h [PMID: 30664827] Antimalarial Ligand 10604
compound 3j [PMID: 33975947] Antimalarial Ligand 11553
compound 1 [PMID: 33929818] Antimalarial Ligand 11709
compound 24 [PMID: 32959656] Antimalarial Ligand 11319
compound 27 [PMID: 32945666] Antimalarial Ligand 11294
compound 28 [PMID: 31188540] Antimalarial Ligand 10617
compound 2 [PMID: 33085774] Antimalarial Ligand 11322
compound 3 [PMID: 32258933] Antimalarial Ligand 11214
compound 55 [PMID: 29889526] Antimalarial Ligand 10016
compound 5 [PMID: 30894487] PDB Ligand Antimalarial Ligand 10398
compound 1u [PMID: 30245402] Antimalarial Ligand 10258
compound VII [WO2021149692A1] Antimalarial Ligand 11926
compound 4 [WO2022008639A1] Antimalarial Ligand 11933
cycloguanil PDB Ligand Antimalarial Ligand 10027
 
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dapsone Approved drug Antimalarial Ligand 10934 Aczone®, NSC-6091
DDD85646 PDB Ligand Antimalarial Ligand 11455 compound 1a [PMID: 24451586], IMP-366
doxycycline Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6464 BMY-28689, Monodox®, Vibramycin®
DSM265 PDB Ligand Antimalarial Ligand 9644
DSM421 PDB Ligand Antimalarial Ligand 10020
DSM502 Antimalarial Ligand 11219
DSM705 PDB Ligand Antimalarial Ligand 11554 compound 79
 
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E209 Antimalarial Ligand 10465
ELQ-300 Antimalarial Ligand 10021 ELQ300
 
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ferroquine Antimalarial Ligand 9972 SSR97193
FNDR-20123 Antimalarial Ligand 11797
forodesine PDB Ligand Antimalarial Ligand 8272 BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, immucillin-H
fosmidomycin PDB Ligand Antimalarial Ligand 9739 FR-31564
 
G Back to top
ganaplacide Antimalarial Ligand 9946 GNF156, KAF156
GSK030 Antimalarial Ligand 10611 GSK3212030A
GSK369796 Antimalarial Ligand 10411 N-tert-Butyl isoquine
 
H Back to top
halofantrine Approved drug Antimalarial Ligand 10019 Halfan®, WR-171669
halofuginone PDB Ligand Antimalarial Ligand 10153
HTI-1 Antimalarial Ligand 11255 compound 1c
hydroxychloroquine Approved drug Immunopharmacology Ligand Antimalarial Ligand 7198 Dolquine®, Plaquenil®
 
I Back to top
IMP-1002 PDB Ligand Antimalarial Ligand 11850
indolmycin PDB Ligand Antimalarial Ligand 11021 PA 155 A, PA-155-A, PA-155A, TAK-083
INE963 Antimalarial Ligand 11929 MMV1582617, NVP-INE963
 
J Back to top
JPC-3210 Antimalarial Ligand 10395 MMV646, MMV892646
JX21108 Antimalarial Ligand 11808
JX35 Antimalarial Ligand 11945
 
K Back to top
KDU691 Antimalarial Ligand 11863
KH7 Antimalarial Ligand 10216 KH 7, KH-7
 
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L-45 PDB Ligand Antimalarial Ligand 11703 L-Moses
lumefantrine Approved drug Antimalarial Ligand 9969 benflumetol
luteolin PDB Ligand Antimalarial Ligand 5215
Lys01 Antimalarial Ligand 10320 compound 3a [PMID: 30344903]
 
M Back to top
M5717 Antimalarial Ligand 9737 DDD107498, DDD498, MMV121
mefloquine Approved drug PDB Ligand Antimalarial Ligand 4252 GNF-Pf-5544, Lariam®, Ro-21-5998-001, WR-142490
mepacrine PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 10172 Atabrine®, quinacrine
meplazumab Antimalarial Ligand 11026 HP6H8, Ketantin®
methnaridine Antimalarial Ligand 11318
MK-4815 PDB Ligand Antimalarial Ligand 10410 MK4815
ML10 Antimalarial Ligand 10225
ML324 Immunopharmacology Ligand Antimalarial Ligand 9584 ML-324, MMV1580488
MMV008138 Antimalarial Ligand 10229 GNF-Pf-4188, TCMDC-125815
MMV009108 Antimalarial Ligand 11463 GNF-Pf-3616
MMV019313 Antimalarial Ligand 11456 TCMDC-123889
MMV024101 Antimalarial Ligand 10017 compound 8 [PMID: 29889526]
MMV030084 Antimalarial Ligand 11201 TCMDC-140369
MMV048 Antimalarial Ligand 9726 MMV390048
MMV1803022 Antimalarial Ligand 11824
MMV688533 Antimalarial Ligand 11704 MMV533, SAR121, SAR441121
MMV689258 Antimalarial Ligand 11466
MMV693183 Antimalarial Ligand 11796
MMV897698 Antimalarial Ligand 11825 compound 6 [PMID: 32678591], OSM-S-369
mupirocin Approved drug PDB Ligand Antimalarial Ligand 10916 Bactroban®, BRL-4910A, BRL-4910F, Centany®, pseudomonic acid
 
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naphthoquine Antimalarial Ligand 10396
NCATS-SM3710 Antimalarial Ligand 11822
NPC1161B Antimalarial Ligand 10393 NPC-1161B
 
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OSM-S-38 Antimalarial Ligand 9708
 
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P218 PDB Ligand Antimalarial Ligand 9740 MMV000147
PA21A092 Antimalarial Ligand 10415 PA92
panobinostat Approved drug PDB Ligand Antimalarial Ligand 7489 Farydak®, LBH-589, LBH589
piperaquine Approved drug Antimalarial Ligand 10025
primaquine Approved drug PDB Ligand Antimalarial Ligand 9952
proguanil Approved drug PDB Ligand Antimalarial Ligand 9676 Bigumal®, chloroguanide, Paludrine®
pyrimethamine Approved drug PDB Ligand Antimalarial Ligand 4800 Daraprim®, GNF-Pf-5586, TCMDC-125860
pyronaridine Antimalarial Ligand 10086 7351, Malaridine®
 
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quinidine Approved drug PDB Ligand Antimalarial Ligand 2342 Quinaglute®, Quinidex®, quinidine hydrochloride
quinine Approved drug PDB Ligand Antimalarial Ligand 2510 GNF-Pf-506, Qualaquin®, Quinate®, quinine bisulphate, quinine sulfate
quisinostat PDB Ligand Antimalarial Ligand 7503 JNJ-26481585
 
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sapanisertib PDB Ligand Antimalarial Ligand 7933 INK 128, INK-128, INK128, MLN0128, TAK-228
SC83288 Antimalarial Ligand 10175
SGC-CBP30 PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 7529
(+)-SJ733 Antimalarial Ligand 9723 (+)-SJ000557733, (+)-SJ557733
SQ-109 Antimalarial Ligand 7997 MMV687273, SQ 109, SQ109
sulfadoxine Approved drug Antimalarial Ligand 10173 sulphadoxine
sulfalene Antimalarial Ligand 10174 Kelfizine®, sulfamethopyrazine, sulfamethoxypyrazine, sulfametopyrazine
sutidiazine Antimalarial Ligand 10024 AZ13721412, MMV674253, ZY19489
 
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tafenoquine Approved drug Antimalarial Ligand 9722 Arakoda®, etaquine, Krintafel®, WR238605
TCMDC-125163 Antimalarial Ligand 10339
TCMDC-135051 Antimalarial Ligand 11109
tebuquine Antimalarial Ligand 10392 WR 228,258
 
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UCT943 Antimalarial Ligand 10093
 
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WEHI-842 PDB Ligand Antimalarial Ligand 10616
WLL-vs Antimalarial Ligand 11321
WM382 PDB Ligand Antimalarial Ligand 11162