ChEMBL ligand: CHEMBL416956 (GNF-Pf-5544, Lariam, Mefaquin, Mefloquine, NSC-758233, RO 21-5998, RO-215998, WR 142,490)
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum D6 [ChEMBL: CHEMBL2367107] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium malariae [ChEMBL: CHEMBL613257] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Protein kinase Pfmrk in Plasmodium falciparum [ChEMBL: CHEMBL4090] [UniProtKB: P90584] There should be some charts here, you may need to enable JavaScript!
A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542] There should be some charts here, you may need to enable JavaScript!
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
ChEMBL	Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-electrode voltage clamp assay	B	5.6	pEC50	2500	nM	EC50	J. Med. Chem. (2015) 58: 2958-2966 [PMID:25790278]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibitory concentration against potassium channel HERG	B	5.25	pIC50	5623.41	nM	IC50	Bioorg. Med. Chem. Lett. (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL	Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique	B	5.25	pIC50	5623.41	nM	IC50	Bioorg. Med. Chem. (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL	Inhibition of human ERG	B	5.26	pIC50	5495.41	nM	IC50	Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.59	pIC50	2600	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibition of hydrogen peroxide-mediated haem detoxification in Plasmodium falciparum	F	4.52	pIC50	30000	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	5.3	pIC50	5000	nM	IC50	Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina	F	6.71	pIC50	194.6	nM	IC50	J. Med. Chem. (2003) 46: 4244-4258 [PMID:13678403]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring amplified Pfmdr1 gene	F	6.74	pIC50	182	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 Sierra Leone	F	6.77	pIC50	169.5	nM	IC50	J. Med. Chem. (2003) 46: 4244-4258 [PMID:13678403]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef ring form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	6.83	pIC50	147	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef by hypoxanthine uptake assay	F	6.85	pIC50	142	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimicrobial activity against Plasmodium falciparum at ring stage	F	6.86	pIC50	137	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by microtiter plate scintillation counting	F	7	pIC50	100	nM	IC50	Bioorg. Med. Chem. Lett. (2010) 20: 3863-3867 [PMID:20627564]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef assessed as DNA positive erythrocytes by hoechst 33342-thiazole orange stain based flow cytometry assay	F	7.04	pIC50	91	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Growth inhibition of chloroquine-sensitive Plasmodium falciparum D10	F	7.05	pIC50	90	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum isolate 208432 infected in human erythrocytes after 48 hrs by flow-cytometry	F	7.05	pIC50	89.4	nM	IC50	J. Med. Chem. (2010) 53: 3552-3557 [PMID:20349996]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring single copy of Pfmdr1 gene	F	7.11	pIC50	77	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef trophozoite form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	7.13	pIC50	74	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35	F	7.19	pIC50	65	nM	IC50	Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Inhibition of Plasmodium falciparum F32A	F	7.21	pIC50	62	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 after 24 hrs by [3H]hypoxanthine uptake	F	7.23	pIC50	59	nM	IC50	J. Nat. Prod. (2002) 65: 614-615 [PMID:11975516]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes	F	7.24	pIC50	57	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 423-424 [PMID:11212126]
ChEMBL	Antimalarial activity against morfloquine-resistant Plasmodium falciparum TM91C235 assessed as [3H]hypoxanthine incorporation	F	7.25	pIC50	55.8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58	F	7.26	pIC50	55	nM	IC50	Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum thailand TM91C235 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	7.26	pIC50	55	nM	IC50	Bioorg. Med. Chem. (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	7.32	pIC50	47.47	nM	IC50	J. Med. Chem. (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2A by hypoxanthine uptake	F	7.34	pIC50	46	nM	IC50	J. Med. Chem. (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum TM90C2A	F	7.34	pIC50	46	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2mef schizont form by hoechst 33342-thiazole orange stain based flow cytometry assay	F	7.36	pIC50	44	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5452-5457 [PMID:19666223]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235 by hypoxanthine uptake	F	7.38	pIC50	42	nM	IC50	J. Med. Chem. (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum TM91C235	F	7.38	pIC50	42	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human O-positive erythrocytes assessed as inhibition of parasite growth by [3H]hypoxanthine incorporation assay	F	7.4	pIC50	40	nM	IC50	J. Nat. Prod. (2011) 74: 2269-2272 [PMID:21954931]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2	F	7.4	pIC50	40	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 3088-3095 [PMID:23562058]
ChEMBL	Inhibition of Plasmodium falciparum 3D7	F	7.4	pIC50	40	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 24 hrs by [3H]hypoxanthine incorporation assay	F	7.41	pIC50	39	nM	IC50	Bioorg. Med. Chem. (2010) 18: 6857-6864 [PMID:20719524]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring NDFCDY genotype after 72 hrs by SYBR green I assay	F	7.41	pIC50	39	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine uptake	F	7.43	pIC50	37.4	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antimalarial activity against Plasmodium falciparum C235	F	7.44	pIC50	36.5	nM	IC50	J. Med. Chem. (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 after 24 hrs by [3H]hypoxanthine uptake	F	7.44	pIC50	36	nM	IC50	J. Nat. Prod. (2002) 65: 614-615 [PMID:11975516]
ChEMBL	Inhibition of Plasmodium falciparum FCR3	F	7.44	pIC50	36	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring K1 allele group of msp1, 3D7 allele group of msp2 gene and 94 bp of 7A11, 196bp of C4M79 and 336bp of C4M69 locus measured on day 23 by [3H]hypoxanthine incorporation assay	F	7.47	pIC50	34.1	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 2283-2284 [PMID:18411319]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by SYBR green I-based assay	F	7.47	pIC50	34	nM	IC50	J. Nat. Prod. (2012) 75: 1299-1304 [PMID:22709138]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	7.48	pIC50	33.46	nM	IC50	J. Med. Chem. (2008) 51: 4388-4391 [PMID:18637666]
ChEMBL	Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone)	F	7.48	pIC50	33.38	nM	IC50	J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Inhibition of Plasmodium falciparum W2	F	7.52	pIC50	30	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Growth inhibition of chloroquine-resistant Plasmodium falciparum KI	F	7.52	pIC50	30	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by SYBR green I-based assay	F	7.54	pIC50	29	nM	IC50	J. Nat. Prod. (2012) 75: 1299-1304 [PMID:22709138]
ChEMBL	In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum African D6	F	7.55	pIC50	28.29	nM	IC50	J. Med. Chem. (2002) 45: 3331-3336 [PMID:12139444]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring NDFCDD genotype after 72 hrs by SYBR green I assay	F	7.55	pIC50	28	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Growth inhibition of Plasmodium falciparum Dd2 ring stage infected erythrocytes after 72 hrs by DAPI fluorimetry	F	7.59	pIC50	25.99	nM	IC50	Antimicrob. Agents Chemother. (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F32-Tanzania by [3H]hypoxanthine uptake	F	7.64	pIC50	23	nM	IC50	J. Nat. Prod. (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235	F	7.65	pIC50	22.45	nM	IC50	J. Med. Chem. (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring NGFSDD genotype after 72 hrs by SYBR green I assay	F	7.68	pIC50	21	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL	Antimalarial activity against mefloquine-resistant, chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine uptake	F	7.7	pIC50	20.1	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as [3H]hypoxanthine incorporation	F	7.7	pIC50	19.9	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimalarial activity against trophozoites stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum	F	7.7	pIC50	19.9	nM	IC50	Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and expressing parental ATP4 after 72 hrs by SYBR green based fluorescence assay	F	7.7	pIC50	19.85	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6	F	7.72	pIC50	19.01	nM	IC50	J. Med. Chem. (2008) 51: 6216-6219 [PMID:18774792]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	7.74	pIC50	18.12	nM	IC50	J. Nat. Prod. (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs by lactate dehydrogenase assay	F	7.74	pIC50	18	nM	IC50	Bioorg. Med. Chem. (2012) 20: 893-902 [PMID:22196513]
ChEMBL	Inhibition of Plasmodium falciparum GP1	F	7.77	pIC50	17	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Inhibitory concentration against Plasmodium falciparum D6 infected erythrocytes	F	7.77	pIC50	17	nM	IC50	J. Med. Chem. (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235	F	7.78	pIC50	16.44	nM	IC50	J. Med. Chem. (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antimalarial activity against mefloquine, chloroquine and quinine-resistant Plasmodium falciparum TM91C235	F	7.78	pIC50	16.44	nM	IC50	Bioorg. Med. Chem. (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM91C235	F	7.79	pIC50	16.4	nM	IC50	J. Med. Chem. (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.8	pIC50	15.7	nM	IC50	J. Med. Chem. (2011) 54: 1157-1169 [PMID:21265542]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay	F	7.84	pIC50	14.38	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 4040-4042 [PMID:19596882]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay	F	7.85	pIC50	14.07	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	7.85	pIC50	14	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing wild type ATP4 after 72 hrs by SYBR green based fluorescence assay	F	7.88	pIC50	13.15	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54	F	7.89	pIC50	13	nM	IC50	J. Med. Chem. (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay	F	7.89	pIC50	12.87	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay	F	7.9	pIC50	12.5	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimicrobial activity against Plasmodium falciparum 3D7 by DAPI growth inhibition assay	F	7.91	pIC50	12.3	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2564-2568 [PMID:19307367]
ChEMBL	Growth inhibition of Plasmodium falciparum 3D7 ring stage in infected erythrocytes after 72 hrs in DAPI fluorimetry	F	7.91	pIC50	12.29	nM	IC50	Antimicrob. Agents Chemother. (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs	F	7.92	pIC50	12	nM	IC50	J. Med. Chem. (2011) 54: 5116-5130 [PMID:21644570]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3	F	7.92	pIC50	12	nM	IC50	J. Med. Chem. (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antimalarial activity against chloroquine,mefloquine-sensitive Plasmodium falciparum D6	F	7.95	pIC50	11.25	nM	IC50	J. Med. Chem. (2008) 51: 4388-4391 [PMID:18637666]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay	F	7.96	pIC50	11.04	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.96	pIC50	11	nM	IC50	Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay	F	7.96	pIC50	11	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antimalarial activity against mefloquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH assay	F	7.96	pIC50	11	nM	IC50	J. Med. Chem. (2011) 54: 4581-4589 [PMID:21644541]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum D6 infected in Aotus lemurinus lemurinus monkey	F	7.96	pIC50	11	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 3467-3477 [PMID:18644969]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 by hypoxanthine uptake	F	7.96	pIC50	11	nM	IC50	J. Med. Chem. (2008) 51: 3437-3448 [PMID:18494463]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.98	pIC50	10.52	nM	IC50	J. Med. Chem. (2007) 50: 5118-5127 [PMID:17887664]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-sensitive Plasmodium falciparum D6	F	7.98	pIC50	10.52	nM	IC50	Bioorg. Med. Chem. (2008) 16: 7039-7045 [PMID:18550377]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	7.98	pIC50	10.5	nM	IC50	J. Med. Chem. (2006) 49: 3790-3799 [PMID:16789736]
ChEMBL	Growth inhibition of Plasmodium falciparum HB3 ring stage in infected erythrocytes after 72 hrs in DAPI fluorimetry	F	8.02	pIC50	9.63	nM	IC50	Antimicrob. Agents Chemother. (2007) 51: 716-723 [PMID:17116676]
ChEMBL	Antimalarial activity against Plasmodium falciparum trophozoites infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining	F	8.07	pIC50	8.5	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green based fluorescence assay	F	8.08	pIC50	8.4	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against Plasmodium falciparum assessed as [35S]Met/Cys incorporation by SYBR green based fluorescence assay	F	8.1	pIC50	8	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs	F	8.1	pIC50	8	nM	IC50	J. Med. Chem. (2011) 54: 5116-5130 [PMID:21644570]
ChEMBL	Inhibition of Plasmodium falciparum FCM29	F	8.1	pIC50	8	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes	F	8.1	pIC50	8	nM	IC50	J. Med. Chem. (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL	Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay	F	8.1	pIC50	8	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs	F	8.11	pIC50	7.78	nM	IC50	J. Nat. Prod. (1999) 62: 59-66 [PMID:9917283]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6	F	8.13	pIC50	7.34	nM	IC50	J. Med. Chem. (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as [3H]hypoxanthine incorporation	F	8.14	pIC50	7.2	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 1320-1324 [PMID:19171802]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum indochina W2 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	8.15	pIC50	7	nM	IC50	Bioorg. Med. Chem. (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay	F	8.15	pIC50	7	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	In vitro sensitivity for Plasmodium falciparum FcB1R	F	8.16	pIC50	6.9	nM	IC50	J. Med. Chem. (2000) 43: 2646-2654 [PMID:10893302]
ChEMBL	Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay	F	8.17	pIC50	6.7	nM	IC50	Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL	Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay	F	8.17	pIC50	6.7	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 4588-4597 [PMID:19704124]
ChEMBL	Antimicrobial activity against Plasmodium falciparum at the ring stage by microscopy	F	8.19	pIC50	6.4	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against ring stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum	F	8.19	pIC50	6.4	nM	IC50	Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimalarial activity against Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum	F	8.2	pIC50	6.3	nM	IC50	Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL	Antimalarial activity against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine uptake	F	8.22	pIC50	6.01	nM	IC50	Bioorg. Med. Chem. Lett. (2011) 21: 786-789 [PMID:21168330]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum W2	F	8.23	pIC50	5.9	nM	IC50