BRD3444 [Ligand Id: 9648] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3560390
  • Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit in Plasmodium falciparum 3D7 [GtoPdb: 2954] [UniProtKB: Q8I246]
  • Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit in Plasmodium falciparum Dd2 [GtoPdb: 2954]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit in Plasmodium falciparum 3D7 [GtoPdb: 2954] [UniProtKB: Q8I246]
GtoPdb - - 7.34 pIC50 46 nM IC50 Nature (2016) 538: 344-349 [PMID:27602946]
GtoPdb Parasite late stage (IV–V) gametocyte assay - 6.18 pEC50 663 nM EC50 Nature (2016) 538: 344-349 [PMID:27602946]
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit in Plasmodium falciparum Dd2 [GtoPdb: 2954]
GtoPdb Parasite growth inhibition assay - 8.05 pEC50 9 nM EC50 Nature (2016) 538: 344-349 [PMID:27602946]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]