tebuquine [Ligand Id: 10392] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL339049 (CI-897, Tebuquina, Tebuquine, WR-228,258, WR-228258) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.28 | pIC50 | 53000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 | F | 7.38 | pIC50 | 42.1 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| ChEMBL | In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 | F | 7.62 | pIC50 | 24.2 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 | F | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 391-392 |
| ChEMBL | In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 | F | 7.68 | pIC50 | 20.8 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 391-392 |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake | F | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298] |
| ChEMBL | In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 | F | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (1997) 40: 437-448 [PMID:9046333] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
