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ChEMBL ligand: CHEMBL339049 (CI-897, WR-228258, Tebuquine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.28 | pIC50 | 53000 | nM | IC50 | Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316] |
ChEMBL | In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 | F | 7.38 | pIC50 | 42.1 | nM | IC50 | J. Med. Chem. (1997) 40: 437-448 [PMID:9046333] |
ChEMBL | In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 | F | 7.62 | pIC50 | 24.2 | nM | IC50 | J. Med. Chem. (1997) 40: 437-448 [PMID:9046333] |
ChEMBL | Antimalarial activity against Plasmodium falciparum K1 | F | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg. Med. Chem. Lett. (1996) 6: 391-392 |
ChEMBL | In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 | F | 7.68 | pIC50 | 20.8 | nM | IC50 | J. Med. Chem. (1997) 40: 437-448 [PMID:9046333] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg. Med. Chem. Lett. (1996) 6: 391-392 |
ChEMBL | In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 | F | 9.05 | pIC50 | 0.9 | nM | IC50 | J. Med. Chem. (1997) 40: 437-448 [PMID:9046333] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake | F | 7.89 | pIC50 | 13 | nM | IC50 | Eur. J. Med. Chem. (2008) 43: 2840-2852 [PMID:18395298] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]