tebuquine [Ligand Id: 10392] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL339049 (CI-897, Tebuquine, WR-228,258)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.28 pIC50 53000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 F 7.38 pIC50 42.1 nM IC50 J. Med. Chem. (1997) 40: 437-448 [PMID:9046333]
ChEMBL In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 F 7.62 pIC50 24.2 nM IC50 J. Med. Chem. (1997) 40: 437-448 [PMID:9046333]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 F 7.68 pIC50 21 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 391-392
ChEMBL In vitro inhibition of chloroquine-resistant Plasmodium falciparum K1 F 7.68 pIC50 20.8 nM IC50 J. Med. Chem. (1997) 40: 437-448 [PMID:9046333]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 F 7.74 pIC50 18 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 391-392
ChEMBL In vitro inhibition of chloroquine-sensitive Plasmodium falciparum HB3 F 9.05 pIC50 0.9 nM IC50 J. Med. Chem. (1997) 40: 437-448 [PMID:9046333]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake F 7.89 pIC50 13 nM IC50 Eur. J. Med. Chem. (2008) 43: 2840-2852 [PMID:18395298]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]