ChEMBL ligand: CHEMBL561057 (Sq109, SQ109, SQ-109, NSC-722041)
Dehydrosqualene synthase in S.aureus [ChEMBL: CHEMBL5440] [UniProtKB: A9JQL9] This target only has 1 pki data point 6.44 1 CHEMBL561057_lig_chart_1 Dehydrosqualene synthase S.aureus There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] This target only has 0 pki data point 0 2 CHEMBL561057_lig_chart_2 Geranylgeranyl pyrophosphate synthetase Human There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] This target only has 0 pki data point 0 3 CHEMBL561057_lig_chart_3 Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 There should be some charts here, you may need to enable JavaScript!
squalene synthase /Squalene synthetase in Human [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] 6.13 4 CHEMBL561057_lig_chart_4 Squalene synthetase Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dehydrosqualene synthase in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5440] [UniProtKB: A9JQL9]
ChEMBL	Inhibition of Staphylococcus aureus ATCC 27659 dehydrosqualene synthase expressed in Escherichia coli BL21(DE3) after 30 mins by spectrophotometric analysis	B	6.44	pKi	360	nM	Ki	J. Med. Chem. (2012) 55: 4367-4372 [PMID:22486710]
ChEMBL	Inhibition of Staphylococcus aureus CrtM	B	4	pIC50	100000	nM	IC50	J. Med. Chem. (2014) 57: 3126-3139 [PMID:24568559]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL	Inhibition of human geranylgeranyl diphosphate synthase	B	5.35	pIC50	4500	nM	IC50	J. Med. Chem. (2014) 57: 3126-3139 [PMID:24568559]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay	F	5.52	pIC50	3000	nM	IC50	J. Med. Chem. (2014) 57: 3126-3139 [PMID:24568559]
squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
GtoPdb	-	-	6.13	pKi	740	nM	Ki	J Med Chem (2012) 55: 4367-72 [PMID:22486710]
ChEMBL	Inhibition of human squalene synthase	B	6.13	pKi	740	nM	Ki	J. Med. Chem. (2012) 55: 4367-4372 [PMID:22486710]
ChEMBL	Inhibition of human SQS	B	4	pIC50	100000	nM	IC50	J. Med. Chem. (2014) 57: 3126-3139 [PMID:24568559]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]