halofuginone [Ligand Id: 10153] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1197091 (Halocur, Halofuginon, Halofuginona, Halofuginone, Ht-100, HT-100) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
| ChEMBL | Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay | F | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2013) 56: 4811-4815 [PMID:23701465] |
| ChEMBL | Antimalarial activity against liver stage of Plasmodium berghei ANKA | F | 7.77 | pEC50 | 17 | nM | EC50 | Medchemcomm (2016) 7: 1535-1545 |
| Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium berghei [GtoPdb: 3056] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 7.77 | pIC50 | 17 | nM | IC50 | ChemMedChem (2012) 7: 844-9 [PMID:22438279] |
| Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3056] [UniProtKB: Q8I5R7] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 9.07 | pEC50 | 0.86 | nM | EC50 | Sci Transl Med (2015) 7: 288ra77 [PMID:25995223] |
| Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium falciparum Dd2 [GtoPdb: 3056] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 9.09 | pEC50 | 0.81 | nM | EC50 | Sci Transl Med (2015) 7: 288ra77 [PMID:25995223] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
