halofuginone [Ligand Id: 10153] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1197091 (Halofuginone, Ht-100, HT-100)
  • Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium berghei [GtoPdb: 3056]
  • Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3056] [UniProtKB: Q8I5R7]
  • Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium falciparum Dd2 [GtoPdb: 3056]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium berghei [GtoPdb: 3056]
GtoPdb Parasite liver stage assay - 7.77 pIC50 17 nM IC50 ChemMedChem (2012) 7: 844-9 [PMID:22438279]
Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3056] [UniProtKB: Q8I5R7]
GtoPdb Parasite growth inhibition assay - 9.07 pEC50 0.86 nM EC50 Sci Transl Med (2015) 7: 288ra77 [PMID:25995223]
Plasmodium falciparum prolyl-tRNA synthetase in Plasmodium falciparum Dd2 [GtoPdb: 3056]
GtoPdb Parasite growth inhibition assay - 9.09 pEC50 0.81 nM EC50 Sci Transl Med (2015) 7: 288ra77 [PMID:25995223]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]