WLL-vs [Ligand Id: 11321] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4456306 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green dye based fluorescence assay | F | 7.04 | pEC50 | 91.6 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta5 proteasome A49S mutant measured after 72 hrs by SYBR green dye based fluorescence assay | F | 7.59 | pEC50 | 26 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta2 proteasome A117D mutant measured after 72 hrs by SYBR green dye based fluorescence assay | F | 8.14 | pEC50 | 7.3 | nM | EC50 | J Med Chem (2019) 62: 6137-6145 [PMID:31177777] |
| proteasome 20S subunit beta 5 in Human [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| GtoPdb | - | - | 6 | pIC50 | 1000 | nM | IC50 | Nature (2016) 530: 233-6 [PMID:26863983] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum [GtoPdb: 3088] | ||||||||
| GtoPdb | - | - | 6.1 | pIC50 | 800 | nM | IC50 | Nature (2016) 530: 233-6 [PMID:26863983] |
| GtoPdb | Parasite growth inhibition assay | - | 8.22 | pEC50 | 6 | nM | EC50 | J Am Chem Soc (2018) 140: 11424-11437 [PMID:30107725] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
