WLL-vs [Ligand Id: 11321] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL4456306
There should be some charts here, you may need to enable JavaScript!
  • proteasome 20S subunit beta 5 in Human [GtoPdb: 2406] [UniProtKB: P28074]
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum [GtoPdb: 3088]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green dye based fluorescence assay F 7.04 pEC50 91.6 nM EC50 J Med Chem (2019) 62: 6137-6145 [PMID:31177777]
ChEMBL Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta5 proteasome A49S mutant measured after 72 hrs by SYBR green dye based fluorescence assay F 7.59 pEC50 26 nM EC50 J Med Chem (2019) 62: 6137-6145 [PMID:31177777]
ChEMBL Antimalarial activity against erythrocytic stage of Plasmodium falciparum Dd2 harboring 20S beta2 proteasome A117D mutant measured after 72 hrs by SYBR green dye based fluorescence assay F 8.14 pEC50 7.3 nM EC50 J Med Chem (2019) 62: 6137-6145 [PMID:31177777]
proteasome 20S subunit beta 5 in Human [GtoPdb: 2406] [UniProtKB: P28074]
GtoPdb - - 6 pIC50 1000 nM IC50 Nature (2016) 530: 233-6 [PMID:26863983]
Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum [GtoPdb: 3088]
GtoPdb - - 6.1 pIC50 800 nM IC50 Nature (2016) 530: 233-6 [PMID:26863983]
GtoPdb Parasite growth inhibition assay - 8.22 pEC50 6 nM EC50 J Am Chem Soc (2018) 140: 11424-11437 [PMID:30107725]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]