ganaplacide   

GtoPdb Ligand ID: 9946

Synonyms: GNF156 | KAF156
Compound class: Synthetic organic
Comment: Ganaplacide is the optimised lead for the imidazolopiperazines (IZPs), a novel class of compounds identified from a phenotypic screen as having antimalarial activity [1].

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 76.18
Molecular weight 411.19
XLogP 4.09
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES NCC(=O)N1CCn2c(C1(C)C)nc(c2Nc1ccc(cc1)F)c1ccc(cc1)F
Isomeric SMILES NCC(=O)N1CCn2c(C1(C)C)nc(c2Nc1ccc(cc1)F)c1ccc(cc1)F
InChI InChI=1S/C22H23F2N5O/c1-22(2)21-27-19(14-3-5-15(23)6-4-14)20(26-17-9-7-16(24)8-10-17)28(21)11-12-29(22)18(30)13-25/h3-10,26H,11-13,25H2,1-2H3
InChI Key BUPRVECGWBHCQV-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
IUPAC Name
2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone
International Nonproprietary Names
INN number INN
10761 ganaplacide
Synonyms
GNF156 | KAF156
Database Links
CAS Registry No. 1261113-96-5 (source: Scifinder)
ChEMBL Ligand CHEMBL2058833
GtoPdb PubChem SID 374883833
PubChem CID 49856296
Search Google for chemical match using the InChIKey BUPRVECGWBHCQV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BUPRVECGWBHCQV
Search PubMed clinical trials ganaplacide
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Search UniChem for chemical match using the InChIKey BUPRVECGWBHCQV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BUPRVECGWBHCQV
Wikipedia KAF156