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ChEMBL ligand: CHEMBL3040038 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against Plasmodium falciparum V1/S harboring DHFR N51I+C59R+S108N+I164L quadruple mutant assessed as reduction parasite growth by [3H]-hypoxanthine incorporation assay | F | 7.25 | pEC50 | 56 | nM | EC50 | MedChemComm (2016) 7: 749-768 |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 8.34 | pIC50 | 4.6 | nM | IC50 | Proc Natl Acad Sci USA (2012) 109: 16823-8 [PMID:23035243] |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite liver stage assay | - | 7.92 | pEC50 | <12 | nM | EC50 | Nat Commun (2018) 9: 1837 [PMID:29743474] |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite exflagellation assay | - | 8.4 | pIC50 | 4 | nM | IC50 | Int J Parasitol (2021) 51: 635-642 [PMID:33713651] |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium vivax [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite liver stage assay | - | 7.35 | pEC50 | 45 | nM | EC50 | Nat Commun (2018) 9: 1837 [PMID:29743474] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]