P218 [Ligand Id: 9740] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3040038
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  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium vivax [GtoPdb: 2981]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum V1/S harboring DHFR N51I+C59R+S108N+I164L quadruple mutant assessed as reduction parasite growth by [3H]-hypoxanthine incorporation assay F 7.25 pEC50 56 nM EC50 MedChemComm (2016) 7: 749-768
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 8.34 pIC50 4.6 nM IC50 Proc Natl Acad Sci USA (2012) 109: 16823-8 [PMID:23035243]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum [GtoPdb: 2981]
GtoPdb Parasite liver stage assay - 7.92 pEC50 <12 nM EC50 Nat Commun (2018) 9: 1837 [PMID:29743474]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
GtoPdb Parasite exflagellation assay - 8.4 pIC50 4 nM IC50 Int J Parasitol (2021) 51: 635-642 [PMID:33713651]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium vivax [GtoPdb: 2981]
GtoPdb Parasite liver stage assay - 7.35 pEC50 45 nM EC50 Nat Commun (2018) 9: 1837 [PMID:29743474]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]