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ChEMBL ligand: CHEMBL3040038 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against wildtype Plasmodium falciparum TM4 | F | 8.34 | pIC50 | 4.6 | nM | IC50 | Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885] |
ChEMBL | Antimalarial activity against Plasmodium falciparum V1/S harboring DHFR N51I+C59R+S108N+I164L quadruple mutant assessed as reduction parasite growth by [3H]-hypoxanthine incorporation assay | F | 7.25 | pEC50 | 56 | nM | EC50 | Medchemcomm (2016) 7: 749-768 |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 8.34 | pIC50 | 4.6 | nM | IC50 | Proc Natl Acad Sci USA (2012) 109: 16823-8 [PMID:23035243] |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite liver stage assay | - | 7.92 | pEC50 | <12 | nM | EC50 | Nat Commun (2018) 9: 1837 [PMID:29743474] |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite exflagellation assay | - | 8.4 | pIC50 | 4 | nM | IC50 | Int J Parasitol (2021) 51: 635-642 [PMID:33713651] |
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium vivax [GtoPdb: 2981] | ||||||||
GtoPdb | Parasite liver stage assay | - | 7.35 | pEC50 | 45 | nM | EC50 | Nat Commun (2018) 9: 1837 [PMID:29743474] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]