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ChEMBL ligand: CHEMBL298470 (SB-252263-AAB, Tafenoquine, WR 238605) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against late (4 to 5) gametocytic stage of Plasmodium falciparum after 72 hrs by image-based HTS assay | F | 5.47 | pIC50 | 3366 | nM | IC50 | J. Med. Chem. (2013) 56: 7727-7740 [PMID:23927763] |
ChEMBL | OSM: Late stage gametocytes. IC50 values determined from 21 point dose response curves. Avery Group Griffith. | F | 5.55 | pIC50 | 2800 | nM | IC50 | Open Source Malaria Deposition 1. http://malaria.ourexperiment.org |
ChEMBL | Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 after 72 hrs by image-based HTS assay | F | 5.97 | pIC50 | 1070 | nM | IC50 | J. Med. Chem. (2013) 56: 7727-7740 [PMID:23927763] |
ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum W2 by SYBR green-based assay | F | 6.66 | pIC50 | 217 | nM | IC50 | Bioorg. Med. Chem. Lett. (2015) 25: 1100-1103 [PMID:25650255] |
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889] | ||||||||
ChEMBL | Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin | F | 6 | pIC50 | <1000 | nM | IC50 | J. Med. Chem. (2013) 56: 7761-7771 [PMID:23927658] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]