ChEMBL ligand: CHEMBL298470 (SB-252263-AAB, Tafenoquina, Tafenoquine, WR 238605)
Plasmodium cynomolgi [ChEMBL: CHEMBL613883] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium cynomolgi (target type: ORGANISM) [ChEMBL: CHEMBL613883]
ChEMBL	Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as reduction in liver schizonts development incubated for 4 days starting on day 4 post-sporozoite inoculation by radial cure mode analysis	F	5.44	pIC50	3610	nM	IC50	ACS Med Chem Lett (2021) 12: 1962-1967 [PMID:34917261]
ChEMBL	Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as reduction in liver hypnozoites development incubated for 4 days starting on day 4 post-sporozoite inoculation by radial cure mode analysis	F	5.46	pIC50	3500	nM	IC50	ACS Med Chem Lett (2021) 12: 1962-1967 [PMID:34917261]
ChEMBL	Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as inhibition of liver schizonts development incubated for 4 days from sporozoite addition by prophylactic assay	F	6.72	pIC50	190	nM	IC50	ACS Med Chem Lett (2021) 12: 1962-1967 [PMID:34917261]
ChEMBL	Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as inhibition of hypnozoite development incubated for 4 days from sporozoite addition by prophylactic assay	F	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2021) 12: 1962-1967 [PMID:34917261]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against late (4 to 5) gametocytic stage of Plasmodium falciparum after 72 hrs by image-based HTS assay	F	5.47	pIC50	3366	nM	IC50	J Med Chem (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL	OSM: Late stage gametocytes. IC50 values determined from 21 point dose response curves. Avery Group Griffith.	F	5.55	pIC50	2800	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 after 72 hrs by image-based HTS assay	F	5.97	pIC50	1070	nM	IC50	J Med Chem (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum NIG59 assessed as parasitic growth inhibition	F	6.05	pIC50	900	nM	IC50	Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as parasitic growth inhibition	F	6.22	pIC50	600	nM	IC50	Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum W2 by SYBR green-based assay	F	6.66	pIC50	217	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1100-1103 [PMID:25650255]
ChEMBL	Antimalarial activity against blood stages Plasmodium falciparum D6 assessed as reduction in parasite growth	F	7.23	pIC50	59	nM	IC50	Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL	Antimalarial activity against blood stages Plasmodium falciparum W2 assessed as inhibition of parasitic growth	F	7.23	pIC50	59	nM	IC50	Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL	Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocytes transfected with GFP-LUC assessed as growth inhibition incubated for 72 hrs by mitotracker Red-CMXROS dye based fluorescence microscopic analysis	F	5.28	pEC50	5250	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin	F	6	pIC50	<1000	nM	IC50	J Med Chem (2013) 56: 7761-7771 [PMID:23927658]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]