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Plasmodium dormant liver stage (hypnozoite)

Stage ID:2
Name:Plasmodium dormant liver stage (hypnozoite)
Associated with:1 targets
1 ligands
Description
During the lifecycle of certain Plasmodium spp., such as P. vivax and P. ovale, a proportion of the liver stage parasites do not achieve maturation immediately and remain in an arrested state of development. This dormant form (hypnozoite) can be reactivated and initiate a cycle of asexual reproduction, causing the clinical symptoms of relapsing malaria.

Interactions

Interactions
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Target Ligand Sp. Action Value Parameter Reference
Plasmodium falciparum phosphatidylinositol 4-kinase MMV048 Pc - 5.0 – 7.2 pIC50 1
pIC50 7.2 (IC50 6.1x10-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [1]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
pIC50 <5.0 (IC50 >1x10-5 M) P. cynomolgi assay to assess elimination of hypnozoites (potential as a radical cure) [1]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay

References

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1. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med, 9 (387). [PMID:28446690]