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Plasmodium dormant liver stage (hypnozoite)

Help on GtoMPdb Parasite Lifecycle Data

The GtoMPdb contains data detailing the parasitic lifecycle activity for antimalarial ligands and their target interactions. Top-level Plasmodium lifecycle stages (collective categories for one or more developmental forms of the parasite) have been defined by GtoMPdb against which interactions in the database have been annotated.

Each individual Parasite Lifecycle Stage page provides a detailed description of the stage and a table displaying all interactions (contained in the database) associated with it.

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Stage ID:2
Name:Plasmodium dormant liver stage (hypnozoite)
Associated with:1 targets
6 ligands
Description
During the lifecycle of certain Plasmodium spp., such as P. vivax and P. ovale, a proportion of the liver stage parasites do not achieve maturation immediately and remain in an arrested state of development. This dormant form (hypnozoite) can be reactivated and initiate a cycle of asexual reproduction, causing the clinical symptoms of relapsing malaria.

Interactions

Interactions
Key to terms and symbols Click column headers to sort
Target Ligand Sp. Action Value Parameter Reference
Plasmodium falciparum phosphatidylinositol 4-kinase beta MMV048 Pc

Plasmodium cynomolgi

P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).
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 - <5.0 – 7.2 pIC50 2
pIC50 7.2 (IC50 6.1x10-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [2]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
pIC50 <5.0 (IC50 >1x10-5 M) P. cynomolgi assay to assess elimination of hypnozoites (potential as a radical cure) [2]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta KDU691 Pc

Plasmodium cynomolgi

P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).
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 - ~6.7 pIC50 1
pIC50 ~6.7 (IC50 ~1.96x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay to assess activity against hypnozoites [1]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA tafenoquine Pc

Plasmodium cynomolgi

P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).
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 - - - 3
P. cynomolgi infected primary rhesus hepatocyte assay, 70-90% inhibition of hypnozoites at 10µM [3]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA primaquine Pc

Plasmodium cynomolgi

P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).
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 - 6.1 pIC50 3
pIC50 6.1 (IC50 8.4x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [3]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA NPC1161B Pc

Plasmodium cynomolgi

P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).
✖
 - - - 3
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [3]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA bulaquine Pc

Plasmodium cynomolgi

P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).
✖
 - - - 3
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [3]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay

References

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1. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ et al.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, 504 (7479): 248-253. [PMID:24284631]

2. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med, 9 (387). [PMID:28446690]

3. Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A et al.. (2014) KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob Agents Chemother, 58 (3): 1586-95. [PMID:24366744]