Lys01 [Ligand Id: 10320] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4282488
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum0246810Highcharts.com
  • Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079]
  • Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079]
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparum heme detoxification proteinpKd Plasmodium​falciparum FCR3pKi Plasmodium​falciparum FCR3pIC50 Plasmodium​falciparum FCR3pEC50 Plasmodium​falciparum FCR3pKd Plasmodium​falciparum K1pKi Plasmodium​falciparum K1pIC50 Plasmodium​falciparum K1pEC50 Plasmodium​falciparum K10246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay F 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay F 7.7 pIC50 20 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079]
GtoPdb Parasite growth inhibition assay - 7.7 pIC50 20 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079]
GtoPdb Parasite growth inhibition assay - 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]