Lys01 [Ligand Id: 10320] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4282488 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay | F | 7.35 | pIC50 | 45 | nM | IC50 | ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay | F | 7.7 | pIC50 | 20 | nM | IC50 | ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903] |
| Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.7 | pIC50 | 20 | nM | IC50 | ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903] |
| Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.35 | pIC50 | 45 | nM | IC50 | ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
