Lys01 [Ligand Id: 10320] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4282488
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  • Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079]
  • Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay F 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay F 7.7 pIC50 20 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079]
GtoPdb Parasite growth inhibition assay - 7.7 pIC50 20 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079]
GtoPdb Parasite growth inhibition assay - 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]