Lys01 [Ligand Id: 10320] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4282488
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  • Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079]
  • Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay F 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay F 7.7 pIC50 20 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
Plasmodium falciparum heme detoxification protein in Plasmodium falciparum FCR3 [GtoPdb: 3079]
GtoPdb Parasite growth inhibition assay - 7.7 pIC50 20 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
Plasmodium falciparum heme detoxification protein in Plasmodium falciparum K1 [GtoPdb: 3079]
GtoPdb Parasite growth inhibition assay - 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]