AN13762 [Ligand Id: 10085] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4072916
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.1 pIC50 80 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum FCB infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.18 pIC50 66 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum TM90C2A infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.19 pIC50 64 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum V1/S infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.2 pIC50 63 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.21 pIC50 62 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.22 pIC50 60 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum T9/94 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.27 pIC50 54 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.28 pIC50 53 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.37 pIC50 43 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.44 pIC50 36 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.46 pIC50 35 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by YOYO-1 dye based flow cytometric analysis F 7.49 pIC50 32.6 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method F 7.21 pIC50 62 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]