ChEMBL ligand: CHEMBL1539 (Fanasil, Fanasulf, J21.373J, NSC-759319, RO 4-4393, RO-4-4393, RO-44393, Sulfadoxin, Sulfadoxine, Sulfadoxinum, Sulforthamidine, Sulphadoxine, Sulphormethoxine, WR-4073)
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum K1 [GtoPdb: 3065] Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum 3D7 [GtoPdb: 3065] [UniProtKB: Q8IAU3] Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum Dd2 [GtoPdb: 3065] Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum HB3 [GtoPdb: 3065] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	4.43	pIC50	37000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antiplasmodial activity against chloroquine and sulfadoxine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes by anti-HRP2 assay	F	4.81	pIC50	>15500	nM	IC50	Bioorg Med Chem (2015) 23: 5979-5984 [PMID:26190461]
ChEMBL	Antimalarial activity against chloroquine/sulfadoxine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as reduction in parasite growth after 72 hrs by HRP2 detection based ELISA	F	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem (2016) 24: 4492-4498 [PMID:27485600]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum W2 by [3H]hypoxanthine uptake	F	5.21	pIC50	6100	nM	IC50	J Med Chem (2009) 52: 952-963 [PMID:19191586]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum D6 by [3H]hypoxanthine uptake	F	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 952-963 [PMID:19191586]
ChEMBL	Antimalarial activity Plasmodium falciparum 3D7	F	7.52	pEC50	30	nM	EC50	Bioorg Med Chem Lett (2010) 20: 4027-4031 [PMID:20610151]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum K1 [GtoPdb: 3065]
GtoPdb	Parasite growth inhibition assay	-	6.65	pIC50	223	nM	IC50	Mol Microbiol (1997) 23: 979-86 [PMID:9076734]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum 3D7 [GtoPdb: 3065] [UniProtKB: Q8IAU3]
GtoPdb	Parasite growth inhibition assay	-	7.14	pIC50	73	nM	IC50	Mol Microbiol (1997) 23: 979-86 [PMID:9076734]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum Dd2 [GtoPdb: 3065]
GtoPdb	Parasite growth inhibition assay	-	5.4	pIC50	3970	nM	IC50	Mol Microbiol (1997) 23: 979-86 [PMID:9076734]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum HB3 [GtoPdb: 3065]
GtoPdb	Parasite growth inhibition assay	-	8.4	pIC50	4	nM	IC50	Mol Microbiol (1997) 23: 979-86 [PMID:9076734]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]