sulfadoxine [Ligand Id: 10173] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1539 (Fanasil, Fanasulf, Fanzil, J21.373J, NSC-759319, RO 4-4393, RO-4-4393, RO-44393, Sulfadoxin, Sulfadoxine, Sulfadoxinum, Sulforthamidine, Sulphadoxine, Sulphormethoxine, WR-4073) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.43 | pIC50 | 37000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | Antiplasmodial activity against chloroquine and sulfadoxine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes by anti-HRP2 assay | F | 4.81 | pIC50 | >15500 | nM | IC50 | Bioorg Med Chem (2015) 23: 5979-5984 [PMID:26190461] |
| ChEMBL | Antimalarial activity against chloroquine/sulfadoxine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as reduction in parasite growth after 72 hrs by HRP2 detection based ELISA | F | 4.82 | pIC50 | 15000 | nM | IC50 | Bioorg Med Chem (2016) 24: 4492-4498 [PMID:27485600] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum W2 by [3H]hypoxanthine uptake | F | 5.21 | pIC50 | 6100 | nM | IC50 | J Med Chem (2009) 52: 952-963 [PMID:19191586] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum D6 by [3H]hypoxanthine uptake | F | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2009) 52: 952-963 [PMID:19191586] |
| ChEMBL | Antimalarial activity Plasmodium falciparum 3D7 | F | 7.52 | pEC50 | 30 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4027-4031 [PMID:20610151] |
| Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum K1 [GtoPdb: 3065] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.65 | pIC50 | 223 | nM | IC50 | Mol Microbiol (1997) 23: 979-86 [PMID:9076734] |
| Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum 3D7 [GtoPdb: 3065] [UniProtKB: Q8IAU3] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.14 | pIC50 | 73 | nM | IC50 | Mol Microbiol (1997) 23: 979-86 [PMID:9076734] |
| Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum Dd2 [GtoPdb: 3065] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 5.4 | pIC50 | 3970 | nM | IC50 | Mol Microbiol (1997) 23: 979-86 [PMID:9076734] |
| Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum HB3 [GtoPdb: 3065] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.4 | pIC50 | 4 | nM | IC50 | Mol Microbiol (1997) 23: 979-86 [PMID:9076734] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
