sulfadoxine [Ligand Id: 10173] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1539 (Fanasil, Fanasulf, Fanzil, J21.373J, NSC-759319, RO 4-4393, RO-44393, RO-4-4393, Sulfadoxin, Sulfadoxine, Sulfadoxinum, Sulforthamidine, Sulphadoxine, Sulphormethoxine, WR-4073)
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  • Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum K1 [GtoPdb: 3065]
  • Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum 3D7 [GtoPdb: 3065] [UniProtKB: Q8IAU3]
  • Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum Dd2 [GtoPdb: 3065]
  • Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum HB3 [GtoPdb: 3065]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.43 pIC50 37000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL Antiplasmodial activity against chloroquine and sulfadoxine-resistant and mefloquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes by anti-HRP2 assay F 4.81 pIC50 >15500 nM IC50 Bioorg. Med. Chem. (2015) 23: 5979-5984 [PMID:26190461]
ChEMBL Antimalarial activity against chloroquine/sulfadoxine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as reduction in parasite growth after 72 hrs by HRP2 detection based ELISA F 4.82 pIC50 15000 nM IC50 Bioorg. Med. Chem. (2016) 24: 4492-4498 [PMID:27485600]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum W2 by [3H]hypoxanthine uptake F 5.21 pIC50 6100 nM IC50 J. Med. Chem. (2009) 52: 952-963 [PMID:19191586]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum D6 by [3H]hypoxanthine uptake F 7.4 pIC50 40 nM IC50 J. Med. Chem. (2009) 52: 952-963 [PMID:19191586]
ChEMBL Antimalarial activity Plasmodium falciparum 3D7 F 7.52 pEC50 30 nM EC50 Bioorg. Med. Chem. Lett. (2010) 20: 4027-4031 [PMID:20610151]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum K1 [GtoPdb: 3065]
GtoPdb Parasite growth inhibition assay - 6.65 pIC50 223 nM IC50 Mol Microbiol (1997) 23: 979-86 [PMID:9076734]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum 3D7 [GtoPdb: 3065] [UniProtKB: Q8IAU3]
GtoPdb Parasite growth inhibition assay - 7.14 pIC50 73 nM IC50 Mol Microbiol (1997) 23: 979-86 [PMID:9076734]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum Dd2 [GtoPdb: 3065]
GtoPdb Parasite growth inhibition assay - 5.4 pIC50 3970 nM IC50 Mol Microbiol (1997) 23: 979-86 [PMID:9076734]
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum HB3 [GtoPdb: 3065]
GtoPdb Parasite growth inhibition assay - 8.4 pIC50 4 nM IC50 Mol Microbiol (1997) 23: 979-86 [PMID:9076734]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]