quinidine [Ligand Id: 2342] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1294 (Quinidine)
  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
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  • Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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  • Kv4.2/Potassium voltage-gated channel subfamily D member 2 in Rat [ChEMBL: CHEMBL1075227] [GtoPdb: 553] [UniProtKB: Q63881]
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  • Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
  • Nav1.5 in Rat [GtoPdb: 582] [UniProtKB: P15389]
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
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  • Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
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  • Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
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  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
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  • Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460]
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  • KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258]
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  • Kv1.4 in Rat [GtoPdb: 541] [UniProtKB: P15385]
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  • Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8]
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  • Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
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  • Kv10.2 in Human [GtoPdb: 571] [UniProtKB: Q8NCM2]
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  • Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of human BChE by Ellman's method B 5.91 pIC50 1230 nM IC50 Bioorg. Med. Chem. (2012) 20: 6669-6679 [PMID:23062825]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of horse BChE by Ellman's method B 5.13 pIC50 7370 nM IC50 Bioorg. Med. Chem. (2012) 20: 6669-6679 [PMID:23062825]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in CHO cells by patch plate method B 5.57 pIC50 2670 nM IC50 J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL Inhibition Assay: Briefly, the experiments were performed on an IonWorks™ HT instrument (Molecular Devices Corporation), which automatically performs electrophysiology measurements in 48 single cells simultaneously in a specialised 384-well plate (PatchPlate™). The cells used were Chinese hamster ovary (CHO) cells stably transfected with hERG. A single-cell suspension is prepared in extracellular solution (Dulbecco's phosphate buffered saline with calcium and magnesium pH 7-7.2) and aliquots added automatically to each well of a PatchPlate™. The cells were then positioned over a small hole at the bottom of each well by applying a vacuum beneath the plate to form an electrical seal. The vacuum was applied through a single compartment common to all wells which is filled with intracellular solution (buffered to pH 7.2 with HEPES). The resistance of each seal was measured via a common ground-electrode in the intracellular compartment and individual electrodes placed into each of the upper wells. Electrical access to the cell was achieved by circulating a perforating agent, amphotericin, underneath the PatchPlate™ and then measuring the pre-compound hERG current. An electrode was positioned in the extracellular compartment and a holding potential of −80 mV applied for 15 sec. The hERG channels were then activated by applying a depolarising step to +40 mV for 5 sec and then clamped at −50 mV for 4 sec to elicit the hERG tail current, before returning to −80 mV for 0.3 s. The test compound was then added at various concentrations (0.008, 0.04, 0.2, 1, 5 and 25 μM) to the upper wells of the PatchPlate™. The test compound was left in contact with the cells for 300 sec before recording currents using the same voltage-step protocol as in the pre-compound scan. Quinidine, an established hERG inhibitor, was included as a positive control. B 5.84 pIC50 1440 nM IC50 US-9402878-B2. Depsipeptide and uses thereof (2016)
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 6.49 pIC50 323.59 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibitory concentration against potassium channel HERG B 6.49 pIC50 323.59 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 6.49 pIC50 323.59 nM IC50 Bioorg. Med. Chem. (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibition of hERG K channel F 6.52 pIC50 300 nM IC50 Cardiovasc. Res. (2011) 91: 53-61 [PMID:21300721]
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay B 4.95 pIC50 11200 nM IC50 J. Med. Chem. (2013) 56: 781-795 [PMID:23241029]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) in MDR1-expressing MDCK cells F 5.07 pKi 8590 nM Ki Pharm. Res. (2002) 19: 765-772 [PMID:12134945]
ChEMBL Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model B 5.3 pKi 5000 nM Ki J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model B 5.59 pKi 2600 nM Ki J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells F 5.82 pKi 1500 nM Ki Pharm. Res. (2001) 18: 171-176 [PMID:11405287]
ChEMBL TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cells F 6.37 pKi 430 nM Ki Pharm. Res. (2003) 20: 161-168 [PMID:12636153]
ChEMBL TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells F 4.47 pIC50 33900 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
ChEMBL TP_TRANSPORTER: cell accumulation of calcein in L-MDR1 cells F 4.47 pIC50 33800 nM IC50 J. Pharmacol. Exp. Ther. (2003) 305: 197-204 [PMID:12649369]
ChEMBL TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells F 4.73 pIC50 18800 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells F 5.25 pIC50 5600 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 5.25 pIC50 5600 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells F 5.66 pIC50 2200 nM IC50 Drug Metab. Dispos. (2000) 28: 655-660 [PMID:10820137]
ChEMBL Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC F 5.66 pIC50 2200 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells F 6 pIC50 1000 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 5 pIC50 10000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells F 5 pIC50 10000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 4.89 pIC50 13000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells F 4.89 pIC50 13000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.62 pIC50 24000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake F 6.8 pIC50 160 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining F 7.05 pIC50 90 nM IC50 Bioorg. Med. Chem. (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL Antimalarial activity against chloroquine sensitive Plasmodium falciparum HB3 after 72 hrs by SYBP Green I dye staining F 7.74 pIC50 18 nM IC50 Bioorg. Med. Chem. (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL In vitro inhibition of parasite development of Plasmodium falciparum W2 in human erythrocytes F 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay F 7.45 pEC50 35.2 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay F 8.02 pEC50 9.59 nM EC50 Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay F 6.71 pIC50 194.4 nM IC50 Eur. J. Med. Chem. (2015) 100: 10-17 [PMID:26063305]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method F 7.68 pIC50 21 nM IC50 Med Chem Res (2007) 16: 213-229
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake F 7.29 pIC50 51 nM IC50 Eur. J. Med. Chem. (2008) 43: 2840-2852 [PMID:18395298]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method F 7.29 pIC50 51 nM IC50 Med Chem Res (2007) 16: 213-229
Kv4.2/Potassium voltage-gated channel subfamily D member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075227] [GtoPdb: 553] [UniProtKB: Q63881]
GtoPdb - - 4.9 pIC50 - - - Br. J. Pharmacol. (2003) 138: 1475-84 [PMID:12721103]
ChEMBL Inhibition of rat potassium channel Kv4.2 by patch-clamp method B 5.66 pIC50 2200 nM IC50 J. Med. Chem. (2007) 50: 2818-2841 [PMID:17506538]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA F 4.78 pIC50 16600 nM IC50 Cardiovasc. Res. (2011) 91: 53-61 [PMID:21300721]
ChEMBL Inhibition of human heart sodium channel Nav1.5 by patch-clamp method B 5.16 pIC50 6900 nM IC50 J. Med. Chem. (2007) 50: 2818-2841 [PMID:17506538]
Nav1.5 in Rat [GtoPdb: 582] [UniProtKB: P15389]
GtoPdb - - 5 pIC50 - - - Mol. Pharmacol. (1989) 36: 150-9 [PMID:2546048];
J. Pharmacol. Exp. Ther. (1994) 268: 187-94 [PMID:8301556]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells F 4.76 pKi 17500 nM Ki J. Pharmacol. Exp. Ther. (1998) 286: 354-361 [PMID:9655880]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in OCT1-expressing HeLa cells F 4.63 pIC50 23400 nM IC50 J. Pharmacol. Exp. Ther. (1999) 288: 1192-1198 [PMID:10027858]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells F 4.84 pKi 14600 nM Ki J. Pharmacol. Exp. Ther. (1998) 287: 800-805 [PMID:9808712]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells F 5.22 pKi 6000 nM Ki Naunyn Schmiedebergs Arch. Pharmacol. (1996) 354: 320-326 [PMID:8878062]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes F 4.9 pIC50 12700 nM IC50 Am. J. Physiol. Renal Physiol. (2001) 281: F454-F468 [PMID:11502595]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells F 4.72 pKi 19100 nM Ki J. Pharmacol. Exp. Ther. (1998) 287: 800-805 [PMID:9808712]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes F 4.84 pIC50 14600 nM IC50 Am. J. Physiol. Renal Physiol. (2001) 281: F454-F468 [PMID:11502595]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells F 5.03 pKi 9270 nM Ki Pharm. Res. (2002) 19: 147-153 [PMID:11883641]
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
ChEMBL Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes F 4.81 pIC50 15600 nM IC50 Cardiovasc. Res. (2011) 91: 53-61 [PMID:21300721]
ChEMBL Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes F 4.81 pIC50 15600 nM IC50 Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
ChEMBL Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit F 4.7 pIC50 19820 nM IC50 Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes F 5 pIC50 10000 nM IC50 Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
ChEMBL Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat ventricular myocytes F 5.25 pIC50 5600 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles
Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460]
GtoPdb - - 5.2 pKd - - - Mol. Pharmacol. (1992) 41: 322-30 [PMID:1538710]
ChEMBL Inhibition of human potassium channel Kv1.5 by patch-clamp method B 5.14 pIC50 7300 nM IC50 J. Med. Chem. (2007) 50: 2818-2841 [PMID:17506538]
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258]
GtoPdb - - 4 pIC50 - - - Neuropharmacology (2006) 51: 896-906 [PMID:16876206];
J. Neurosci. (2003) 23: 11681-91 [PMID:14684870]
Kv1.4 in Rat [GtoPdb: 541] [UniProtKB: P15385]
GtoPdb - - 3.7 pIC50 - - - Eur. J. Pharmacol. (1995) 281: 151-9 [PMID:7589202]
Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8]
GtoPdb - - 4.8 pKd - - - Eur. J. Hum. Genet. (2002) 10: 36-43 [PMID:11896454]
Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259]
GtoPdb - - 5.8 pIC50 - - - FEBS Lett. (2002) 514: 204-8 [PMID:11943152]
Kv10.2 in Human [GtoPdb: 571] [UniProtKB: Q8NCM2]
GtoPdb - - 3.8 pIC50 - - - Mol. Pharmacol. (2004) 65: 1120-9 [PMID:15102940]
Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
GtoPdb - - 4.6 pKi 25300 nM Ki Mol. Pharmacol. (2005) 68: 1397-407 [PMID:16099839];
Clin. Pharmacol. Ther. (2016) 100: 489-499 [PMID:27506881]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]