artesunate [Ligand Id: 9956] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL361497 (Arsumax, Artesunate, NSC-712571)
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
1 CHEMBL361497_lig_chart_1 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922]
  • This target only has 0 pki data point
2 CHEMBL361497_lig_chart_2 Plasmodium falciparum 3D7 Plasmodium falciparum 3D7
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
  • This target only has 0 pki data point
3 CHEMBL361497_lig_chart_3 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1
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  • Plasmodium falciparum NF54 [ChEMBL: CHEMBL2367131]
  • This target only has 0 pki data point
4 CHEMBL361497_lig_chart_4 Plasmodium falciparum NF54 Plasmodium falciparum NF54
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  • Plasmodium malariae [ChEMBL: CHEMBL613257]
  • This target only has 0 pki data point
5 CHEMBL361497_lig_chart_5 Plasmodium malariae Plasmodium malariae
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  • Plasmodium vivax [ChEMBL: CHEMBL613013]
  • This target only has 0 pki data point
6 CHEMBL361497_lig_chart_6 Plasmodium vivax Plasmodium vivax
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  • Plasmodium yoelii [ChEMBL: CHEMBL612889]
  • This target only has 0 pki data point
7 CHEMBL361497_lig_chart_7 Plasmodium yoelii Plasmodium yoelii
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH release assay F 5.28 pIC50 <5202 nM IC50 Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay F 5.28 pIC50 <5200 nM IC50 J Nat Prod (2018) 81: 41-48 [PMID:29309141]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 5.52 pIC50 3000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Gametocytocidal antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 late gametocyte stage after 72 hrs by alamar blue assay F 5.64 pIC50 2300 nM IC50 J. Nat. Prod. (2013) 76: 388-393 [PMID:23286240]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay F 5.68 pIC50 2100 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay F 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 5.77 pIC50 1700 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 4 & 5) F 6.97 pIC50 108 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 2 & 3) F 7.14 pIC50 72 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL Antiplasmodial activity chloroquine-resistant Plasmodium falciparum Dd2 by lactate dehydrogenase assay F 7.34 pIC50 46 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1214-1217 [PMID:24468411]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 F 7.51 pIC50 31.2 nM IC50 Eur. J. Med. Chem. (2013) 66: 314-323 [PMID:23811093]
ChEMBL Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by lactate dehydrogenase assay F 7.51 pIC50 31.2 nM IC50 J. Med. Chem. (2014) 57: 435-448 [PMID:24354322]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation F 7.56 pIC50 27.7 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation F 7.58 pIC50 26.6 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation F 7.58 pIC50 26.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.58 pIC50 26.2 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.58 pIC50 26.2 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation F 7.61 pIC50 24.3 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.63 pIC50 23.6 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.63 pIC50 23.6 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone M4 assessed as inhibition of [3H]hypoxanthine incorporation F 7.67 pIC50 21.3 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Gametocytocidal activity against synchronous stage 1 to 3 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by luciferase reporter gene assay F 7.72 pIC50 19 nM IC50 J. Med. Chem. (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. GSK Tres Cantos. F 7.72 pIC50 19 nM IC50 Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL Antimalarial activity against chloroquine-resistant asexual intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as inhibition of parasite growth by lactate dehydrogenase assay F 7.76 pIC50 17.4 nM IC50 Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation F 7.77 pIC50 17 nM IC50 Med Chem Res (2011) 20: 321-332
ChEMBL Antimalarial activity against Plasmodium falciparum D10 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation F 7.77 pIC50 16.8 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation F 7.8 pIC50 16 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH release assay F 7.82 pIC50 15 nM IC50 Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.83 pIC50 14.9 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.83 pIC50 14.9 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antiplasmodial activity against chloroquine-resistant synchronized trophozoite stage of Plasmodium falciparum Dd2 after 48 hrs by NBT dye based LDH assay F 7.84 pIC50 14.3 nM IC50 J Med Chem (2017) 60: 10245-10256 [PMID:29185748]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation F 7.85 pIC50 14.2 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.87 pIC50 13.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation F 7.87 pIC50 13.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation F 7.88 pIC50 13.3 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against chloroquine-sensitive asexual intraerythrocytic stage of Plasmodium falciparum NF54 assessed as inhibition of parasite growth by lactate dehydrogenase assay F 7.9 pIC50 12.6 nM IC50 Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation F 7.91 pIC50 12.4 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation F 7.92 pIC50 12.1 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as [3H]-hypoxanthine incorporation by lactate dehydrogenase assay F 7.96 pIC50 11 nM IC50 Eur. J. Med. Chem. (2015) 92: 91-102 [PMID:25544689]
ChEMBL Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58 F 8 pIC50 10 nM IC50 Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay F 8.03 pIC50 9.3 nM IC50 Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL Antiplasmodial activity against asexual erythrocytic stage of chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 48 hrs by lactate dehydrogenase assay F 8.09 pIC50 8.1 nM IC50 Eur. J. Med. Chem. (2014) 76: 470-481 [PMID:24602791]
ChEMBL Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 late stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based imaging method F 8.1 pIC50 8 nM IC50 Eur J Med Chem (2018) 158: 801-813 [PMID:30245402]
ChEMBL Antimicrobial activity against Plasmodium falciparum at ring stage F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay F 8.1 pIC50 8 nM IC50 J. Med. Chem. (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL Antiplasmodial activity against chloroquine-resistant synchronized trophozoite stage of Plasmodium falciparum 7G8 after 48 hrs by NBT dye based LDH assay F 8.11 pIC50 7.7 nM IC50 J Med Chem (2017) 60: 10245-10256 [PMID:29185748]
ChEMBL Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay F 8.17 pIC50 6.77 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum D10 assessed as parasite growth inhibition by lactate dehydrogenase assay F 8.2 pIC50 6.3 nM IC50 J. Med. Chem. (2014) 57: 435-448 [PMID:24354322]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 asexual gametocytes F 8.22 pIC50 6 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method F 8.24 pIC50 5.71 nM IC50 Eur. J. Med. Chem. (2015) 90: 33-44 [PMID:25461309]
ChEMBL Antiplasmodial activity against chloroquine-sensitive synchronized trophozoite stage of Plasmodium falciparum NF54 after 48 hrs by NBT dye based LDH assay F 8.25 pIC50 5.6 nM IC50 J Med Chem (2017) 60: 10245-10256 [PMID:29185748]
ChEMBL Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting F 8.28 pIC50 5.3 nM IC50 Eur. J. Med. Chem. (2012) 52: 82-97 [PMID:22459876]
ChEMBL Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay F 8.28 pIC50 <5.2 nM IC50 Bioorg. Med. Chem. (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in mouse at 30 mg/kg, po F 8.38 pIC50 4.2 nM IC50 J. Med. Chem. (2013) 56: 2547-2555 [PMID:23489135]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 within 48 hrs F 8.38 pIC50 4.2 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 667-672 [PMID:17145800]
ChEMBL Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35 F 8.39 pIC50 4.1 nM IC50 Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antiplasmodial activity against drug-sensitive blood stage Plasmodium falciparum 3D7 by SYBR green 1 staining based fluorescence assay F 8.4 pIC50 4 nM IC50 J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting F 8.4 pIC50 4 nM IC50 MedChemComm (2017) 8: 1152-1157
ChEMBL Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 F 8.4 pIC50 4 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum NF54 F 8.4 pIC50 4 nM IC50 J. Med. Chem. (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.42 pIC50 3.8 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against late (4 to 5) gametocytic stage of Plasmodium falciparum after 72 hrs by image-based HTS assay F 8.46 pIC50 3.43 nM IC50 J. Med. Chem. (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay F 8.48 pIC50 3.3 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3597-3604 [PMID:20547797]
ChEMBL Antiplasmodial activity against chloroquine/cycloguanil/pyrimethamine-resistant blood stage Plasmodium falciparum K1 by SYBR green 1 staining based fluorescence assay F 8.52 pIC50 3 nM IC50 J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 early stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based imaging method F 8.52 pIC50 3 nM IC50 Eur J Med Chem (2018) 158: 801-813 [PMID:30245402]
ChEMBL Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 F 8.52 pIC50 3 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 early stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method F 8.52 pIC50 3 nM IC50 J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.52 pIC50 3 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 ring stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method F 8.52 pIC50 3 nM IC50 J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method F 8.59 pIC50 2.6 nM IC50 Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR-3/Gambia F 8.6 pIC50 2.5 nM IC50 MedChemComm (2014) 5: 842-852 [PMID:25089179]
ChEMBL Antimicrobial activity against Plasmodium falciparum NF54 F 8.6 pIC50 2.5 nM IC50 ACS Med. Chem. Lett. (2011) 2: 316-319 [PMID:21666827]
ChEMBL Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation F 8.64 pIC50 2.3 nM IC50 J. Med. Chem. (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 F 8.64 pIC50 2.3 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 after 72 hrs by image-based HTS assay F 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 asexual blood stages after 3 days by HRP2 detection based ELISA method F 8.7 pIC50 2 nM IC50 J. Med. Chem. (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation F 8.7 pIC50 2 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.7 pIC50 2 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antispasmodial activity against multidrug-resistant asexual blood stages of Plasmodium falciparum Dd2 after 72 hrs by HRP2-based ELISA F 8.7 pIC50 2 nM IC50 J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL Antispasmodial activity against chloroquine-sensitive asexual blood stages of Plasmodium falciparum 3D7 after 72 hrs by HRP2-based ELISA F 8.72 pIC50 1.9 nM IC50 J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.72 pIC50 1.9 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.74 pIC50 1.8 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.77 pIC50 1.7 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29 F 8.8 pIC50 1.6 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL Antiparasitic activity against Plasmodium falciparum Dd2 assessed as growth inhibition after 72 hrs by DAPI staining-based confocal image analysis F 8.89 pIC50 1.3 nM IC50 Eur. J. Med. Chem. (2016) 110: 43-64 [PMID:26807544]
ChEMBL Antimalarial activity against trophozoites stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum F 8.92 pIC50 1.19 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining based confocal microplate imaging method F 9 pIC50 1 nM IC50 J Nat Prod (2017) 80: 3211-3217 [PMID:29236492]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining based confocal microplate imaging method F 9 pIC50 1 nM IC50 J Nat Prod (2017) 80: 3211-3217 [PMID:29236492]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by DAPI staining-based fluorescence microscopic analysis F 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2017) 27: 4091-4095 [PMID:28774427]
ChEMBL Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 ring stage infected in human erythrocytes after 72 hrs by DAPI staining based method F 9 pIC50 1 nM IC50 J Nat Prod (2018) 81: 1588-1597 [PMID:29969262]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining based fluorescence assay F 9 pIC50 1 nM IC50 J Nat Prod (2018) 81: 1079-1083 [PMID:29533611]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by DAPI staining based high throughput screening assay F 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2017) 27: 2602-2607 [PMID:28400231]
ChEMBL Antimalarial activity against Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum F 9.04 pIC50 0.92 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antiparasitic activity against chloroquine/quinine/pyrimethamine/sulfadoxine/NITD609-resistant Plasmodium falciparum Dd2 clone 2 assessed as growth inhibition after 72 hrs by DAPI staining-based confocal image analysis F 9.05 pIC50 0.9 nM IC50 Eur. J. Med. Chem. (2016) 110: 43-64 [PMID:26807544]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining based fluorescence assay F 9.05 pIC50 0.9 nM IC50 J Nat Prod (2018) 81: 1079-1083 [PMID:29533611]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by DAPI staining-based fluorescence microscopic analysis F 9.05 pIC50 0.9 nM IC50 Bioorg Med Chem Lett (2017) 27: 4091-4095 [PMID:28774427]
ChEMBL Antimalarial activity against ring stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum F 9.06 pIC50 0.88 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimalarial activity against Plasmodium falciparum infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 9.17 pIC50 0.68 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by DAPI staining based high throughput screening assay F 9.17 pIC50 0.67 nM IC50 Bioorg Med Chem Lett (2017) 27: 2602-2607 [PMID:28400231]
ChEMBL Antiplasmodial activity against 4-aminoquinoline/antifolates-resistant Plasmodium falciparum Dd2 ring stage infected in human erythrocytes after 72 hrs by DAPI staining based method F 9.17 pIC50 0.67 nM IC50 J Nat Prod (2018) 81: 1588-1597 [PMID:29969262]
ChEMBL Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method F 9.3 pIC50 0.5 nM IC50 Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human RBC after 72 hrs by DAPI staining based confocal microscopic method F 9.32 pIC50 0.48 nM IC50 J Nat Prod (2017) 80: 114-125 [PMID:28001067]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis F 9.35 pIC50 0.44 nM IC50 J. Nat. Prod. (2015) 78: 2932-2939 [PMID:26651537]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human RBC after 72 hrs by DAPI staining based confocal microscopic method F 9.36 pIC50 0.44 nM IC50 J Nat Prod (2017) 80: 114-125 [PMID:28001067]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green dye fluorescence assay F 8.01 pEC50 9.7 nM EC50 Bioorg Med Chem (2018) 26: 3610-3618 [PMID:29887512]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 F 8.03 pEC50 9.41 nM EC50 Bioorg Med Chem (2018) 26: 5730-5741 [PMID:30391094]
ChEMBL Antimalarial activity against synchronized ring stage of Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green1 dye based fluorescence assay F 8.05 pEC50 8.9 nM EC50 ACS Med Chem Lett (2018) 9: 1128-1133 [PMID:30429957]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage parasites infected in human erythrocytes after 72 hrs by SYBR Green 1 dye based fluorescence assay F 8.09 pEC50 8.2 nM EC50 ACS Med Chem Lett (2018) 9: 534-539 [PMID:29937978]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 harboring pfs16-LUC-GFP late stage 4 to 5 gametocytes after 48 hrs by MitoTracker Red staining based confocal microscopy F 8.1 pEC50 8 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay F 8.1 pEC50 8 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay F 8.22 pEC50 6 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 harboring pfs16-LUC-GFP early stage 1 to 3 gametocytes after 48 hrs by MitoTracker Red staining based confocal microscopy F 8.52 pEC50 3 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 harboring pfs16-LUC-GFP ring stage gametocytes after 24 hrs by MitoTracker Red staining based confocal microscopy F 8.52 pEC50 3 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay F 8.75 pEC50 1.76 nM EC50 Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I assay F 8.05 pIC50 9 nM IC50 Bioorg. Med. Chem. (2015) 23: 5452-5458 [PMID:26260339]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 F 8.38 pIC50 4.2 nM IC50 Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method F 8.4 pIC50 4 nM IC50 Eur. J. Med. Chem. (2015) 90: 33-44 [PMID:25461309]
ChEMBL Antiparasitic activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 72 hrs by DAPI staining-based confocal image analysis F 8.68 pIC50 2.1 nM IC50 Eur. J. Med. Chem. (2016) 110: 43-64 [PMID:26807544]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method F 8.72 pIC50 1.9 nM IC50 J. Med. Chem. (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay F 8.8 pIC50 1.6 nM IC50 Bioorg. Med. Chem. (2013) 21: 7392-7397 [PMID:24148834]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA F 9.09 pIC50 0.82 nM IC50 Eur. J. Med. Chem. (2014) 75: 403-412 [PMID:24561670]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis F 9.3 pIC50 0.5 nM IC50 J. Nat. Prod. (2015) 78: 2932-2939 [PMID:26651537]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay F 8.71 pEC50 1.97 nM EC50 Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay in presence of ascorbic acid F 6.15 pIC50 700 nM IC50 Eur. J. Med. Chem. (2015) 95: 16-28 [PMID:25791675]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 8 pIC50 10 nM IC50 MedChemComm (2014) 5: 842-852 [PMID:25089179]
ChEMBL Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay F 8.05 pIC50 8.97 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis F 8.31 pIC50 4.9 nM IC50 MedChemComm (2011) 2: 661-665
ChEMBL Antiplasmodial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.4 pIC50 4 nM IC50 J. Med. Chem. (2015) 58: 8713-8722 [PMID:26502160]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 F 8.46 pIC50 3.5 nM IC50 Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 8.47 pIC50 3.4 nM IC50 J. Med. Chem. (2013) 56: 2547-2555 [PMID:23489135]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 8.49 pIC50 3.2 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1291-1296 [PMID:18268087]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K1 F 8.52 pIC50 3 nM IC50 J. Med. Chem. (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 F 8.52 pIC50 3 nM IC50 J. Med. Chem. (2014) 57: 2789-2798 [PMID:24568587]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay F 8.52 pIC50 3 nM IC50 J. Med. Chem. (2015) 58: 7572-7579 [PMID:26322748]
ChEMBL Antiplasmodial activity chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting F 8.55 pIC50 2.8 nM IC50 Eur. J. Med. Chem. (2012) 52: 82-97 [PMID:22459876]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay F 8.59 pIC50 2.6 nM IC50 Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth after 48 hrs by [3H]hypoxanthine reuptake assay F 8.61 pIC50 2.46 nM IC50 Eur. J. Med. Chem. (2009) 44: 5071-5079 [PMID:19811859]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation F 9 pIC50 1 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.51 pEC50 3.1 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131]
ChEMBL Gametocytocidal activity against transgenic Plasmodium falciparum NF54-pfs16-GFP late stage gametocytes after 72 hrs by mitotracker red CM-H2XRos dye based confocal imaging assay F 7.36 pIC50 44 nM IC50 J. Med. Chem. (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay F 7.62 pIC50 24.2 nM IC50 Bioorg. Med. Chem. (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay F 7.7 pIC50 20 nM IC50 MedChemComm (2013) 4: 724-730
ChEMBL