ChEMBL ligand: CHEMBL1956285 (Dsm265, Dsm-265, DSM265)
Dihydroorotate dehydrogenase in Plasmodium falciparum [ChEMBL: CHEMBL3486] [UniProtKB: Q54A96] dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum NF54 [GtoPdb: 2949] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dihydroorotate dehydrogenase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3486] [UniProtKB: Q54A96]
ChEMBL	Inhibition of Plasmodium falciparum C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay	B	7.48	pIC50	33	nM	IC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127]
ChEMBL	Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay	B	4	pIC50	>100000	nM	IC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring DHODH mutant	F	6.98	pIC50	104	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antimalarial activity against wild type Plasmodium falciparum Dd2	F	8.37	pIC50	4.3	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 transfected with yeast DHODH by [3H]hypoxanthine incorporation assay	F	4.7	pEC50	>20000	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 by [3H]hypoxanthine incorporation assay	F	7.07	pEC50	86	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.24	pEC50	57	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.34	pEC50	46	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against atovoquone-resistant Plasmodium falciparum TM90C2A by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.51	pEC50	31	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum HB3 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.57	pEC50	27	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum D6 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.66	pEC50	22	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against atovoquone-resistant Plasmodium falciparum TM90C2B by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.82	pEC50	15	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of albumax	F	8.11	pEC50	7.8	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.24	pEC50	57	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb	Steady-state kinetic analysis.	-	7.52	pIC50	30	nM	IC50	J. Med. Chem. (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum NF54 [GtoPdb: 2949]
GtoPdb	Parasite growth inhibition assay	-	7.52	pIC50	30	nM	IC50	Sci Transl Med (2015) 7: 296ra111 [PMID:26180101]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
GtoPdb	Steady-state kinetic analysis.	-	7.14	pIC50	72	nM	IC50	J. Med. Chem. (2020) 63: 4929-4956 [PMID:32248693]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]