ChEMBL ligand: CHEMBL1956285 (Dsm265, Dsm-265, DSM265)
Dihydroorotate dehydrogenase in Plasmodium falciparum [ChEMBL: CHEMBL3486] [UniProtKB: Q54A96] dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127] This target only has 0 pki data point 0 1 CHEMBL1956285_lig_chart_1 Dihydroorotate dehydrogenase Plasmodium falciparumHuman There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] This target only has 0 pki data point 0 2 CHEMBL1956285_lig_chart_2 Plasmodium falciparum Plasmodium falciparum There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] This target only has 0 pki data point 0 3 CHEMBL1956285_lig_chart_3 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1 There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] This target only has 0 pki data point 0 4 CHEMBL1956285_lig_chart_4 Plasmodium vivax Plasmodium vivax There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum NF54 [GtoPdb: 2949] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] This target only has 0 pki data point 0 5 CHEMBL1956285_lig_chart_5 Plasmodium falciparum dihydroorotate dehydrogenase Plasmodium falciparumPlasmodium falciparum NF54Plasmodium vivax There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Dihydroorotate dehydrogenase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3486] [UniProtKB: Q54A96]
ChEMBL	Inhibition of Plasmodium falciparum C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay	B	7.48	pIC50	33	nM	IC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Inhibition of Plasmodium falciparum DHODH expressed in Escherichia coli using L-dihydroorotate as substrate	B	8	pIC50	10	nM	IC50	J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127]
ChEMBL	Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay	B	4	pIC50	>100000	nM	IC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Inhibition of human DHODH expressed in Escherichia coli by DCIP staining-based spectrophotometric analysis	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2019) 165: 332-346 [PMID:30703745]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring DHODH mutant	F	6.98	pIC50	104	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antimalarial activity against wild type Plasmodium falciparum Dd2	F	8.37	pIC50	4.3	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 transfected with yeast DHODH by [3H]hypoxanthine incorporation assay	F	4.7	pEC50	>20000	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against schizont stage of Plasmodium falciparum clinical isolate	F	6.04	pEC50	918	nM	EC50	J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 by [3H]hypoxanthine incorporation assay	F	7.07	pEC50	86	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.24	pEC50	57	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.34	pEC50	46	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against atovoquone-resistant Plasmodium falciparum TM90C2A by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.51	pEC50	31	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum HB3 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.57	pEC50	27	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum D6 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.66	pEC50	22	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against atovoquone-resistant Plasmodium falciparum TM90C2B by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.82	pEC50	15	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of albumax	F	8.11	pEC50	7.8	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	8.11	pEC50	7.8	nM	EC50	J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL	Antimalarial activity against mefloquine/chloroquine-resistant Plasmodium falciparum asexual blood stage forms	F	8.15	pEC50	7	nM	EC50	J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay in presence of human serum	F	7.24	pEC50	57	nM	EC50	J. Med. Chem. (2011) 54: 5540-5561 [PMID:21696174]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL	Antimalarial activity against Plasmodium vivax infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 40 hrs followed by addition of [3H]-hypoxanthine and measured after 4 hrs by liquid scintillation counting method	F	6.28	pEC50	529	nM	EC50	J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL	Antimalarial activity against schizont stage of Plasmodium vivax clinical isolate	F	6.72	pEC50	190	nM	EC50	J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb	Steady-state kinetic analysis.	-	7.52	pIC50	30	nM	IC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum NF54 [GtoPdb: 2949]
GtoPdb	Parasite growth inhibition assay	-	7.52	pIC50	30	nM	IC50	Sci Transl Med (2015) 7: 296ra111 [PMID:26180101]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
GtoPdb	Steady-state kinetic analysis.	-	7.14	pIC50	72	nM	IC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]