ChEMBL ligand: CHEMBL430060 (Acipidin)
coagulation factor III, tissue factor/Coagulation factor III in Human [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726] There should be some charts here, you may need to enable JavaScript!
Histone deacetylase in Cryptosporidium parvum [ChEMBL: CHEMBL4740] [UniProtKB: Q9GU59] Histone deacetylase in Plasmodium falciparum [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!
Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
ChEMBL	Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay	B	6.7	pIC50	200	nM	IC50	J Biol Chem (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL	Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay	B	6.82	pIC50	150	nM	IC50	J Biol Chem (2007) 282: 28408-28418 [PMID:17675290]
Histone deacetylase in Cryptosporidium parvum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4740] [UniProtKB: Q9GU59]
ChEMBL	Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2001) 11: 113-117 [PMID:11206439]
ChEMBL	Tested for Histone deacetylase enzyme inhibition assay using Eimeria tenella extract	B	9	pIC50	1	nM	IC50	J Med Chem (2000) 43: 4919-4922 [PMID:11124001]
Histone deacetylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7]
ChEMBL	Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells	B	9	pIC50	1	nM	IC50	J Med Chem (2009) 52: 2185-2187 [PMID:19317450]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of human HDAC1	B	10.4	pKi	0.04	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
GtoPdb	-	-	10.4	pKi	0.04	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of HDAC1 (mean IC50)	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem Lett (2006) 16: 5948-5952 [PMID:16987657]
ChEMBL	Inhibition of HDAC1	B	7.36	pIC50	44	nM	IC50	J Med Chem (2008) 51: 2350-2353 [PMID:18370373]
ChEMBL	Inhibition of human recombinant C-terminally flag tagged HDAC1	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5528-5532 [PMID:18809328]
ChEMBL	Inhibition of C-terminal FLAG tagged HDAC1	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3081-3084 [PMID:19410459]
ChEMBL	Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3651-3656 [PMID:19457659]
ChEMBL	Inhibition of HDAC1 in HEK293 cells	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of HDAC1 (unknown origin)	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL	Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assay	B	7.66	pIC50	22	nM	IC50	J Med Chem (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL	Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry	B	7.66	pIC50	22	nM	IC50	ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958]
ChEMBL	Inhibition of HDAC1	B	7.89	pIC50	13	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2549-2554 [PMID:18381239]
ChEMBL	Inhibition of human recombinant HDAC1 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	B	7.96	pIC50	11	nM	IC50	ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543]
ChEMBL	Inhibition of HDAC1	B	9.15	pIC50	0.7	nM	IC50	Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
GtoPdb	-	-	9.92	pKi	0.12	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human HDAC2	B	9.92	pKi	0.12	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis	B	7.46	pIC50	35	nM	IC50	ACS Med Chem Lett (2012) 3: 505-508 [PMID:24900500]
ChEMBL	Inhibition of HDAC2 (unknown origin)	B	7.46	pIC50	35	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL	Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	B	7.47	pIC50	34	nM	IC50	ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543]
ChEMBL	Inhibition of HDAC2	B	9	pIC50	1	nM	IC50	Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442]
GtoPdb	-	-	6.92	pEC50	120	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL	Inhibition of human HDAC3	B	9.59	pKi	0.26	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
GtoPdb	-	-	9.59	pKi	0.26	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human recombinant HDAC3 after 30 mins by fluorimetric assay	B	7.54	pIC50	29	nM	IC50	J Med Chem (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL	Inhibition of HDAC3 (unknown origin)	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL	Inhibition of HDAC3 in HEK293 cells	B	8.01	pIC50	9.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of flag-tagged HDAC3	B	8.6	pIC50	2.5	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of HDAC3	B	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442]
GtoPdb	-	-	7.37	pEC50	43	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
GtoPdb	-	-	7.52	pEC50	30	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618]
ChEMBL	Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay	B	8.82	pKi	1.5	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569]
GtoPdb	-	-	9.59	pKi	0.26	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry	B	7.54	pIC50	29	nM	IC50	ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958]
ChEMBL	Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay	B	7.8	pIC50	15.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569]
ChEMBL	Inhibition of human recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	B	7.89	pIC50	13	nM	IC50	ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543]
GtoPdb	-	-	7.37	pEC50	43	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
GtoPdb	-	-	7.52	pEC50	30	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL	Inhibition of wild type HDAC4 expressed in Escherichia coli	B	5.06	pIC50	8700	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli	B	5.44	pIC50	3600	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Inhibition of flag-tagged HDAC4 by pull-down assay	B	8.62	pIC50	2.4	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of flag-tagged HDAC4 by Biomol assay	B	8.92	pIC50	1.2	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL	Inhibition of flag-tagged HDAC4	B	9	pIC50	1	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 17335-17340 [PMID:17956988]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay	B	6.91	pKi	123.4	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569]
ChEMBL	Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958]
ChEMBL	Inhibition of HDAC6 (unknown origin)	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL	Inhibition of human recombinant HDAC6 after 30 mins by fluorimetric assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL	Inhibition of human recombinant HDAC6 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543]
ChEMBL	Inhibition of HDAC6	B	5.02	pIC50	9600	nM	IC50	Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442]
ChEMBL	Inhibition of HDAC6 in HEK293 cells	B	5.37	pIC50	4300	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL	Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay	B	6.18	pIC50	665.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2809-2812 [PMID:18430569]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL	Activity of human HDAC8	B	7.31	pKi	49	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
GtoPdb	-	-	7.31	pKi	49	nM	Ki	Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL	Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assay	B	6.12	pIC50	760	nM	IC50	J Med Chem (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL	Inhibition of HDAC8 (unknown origin)	B	6.12	pIC50	760	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL	Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometry	B	6.12	pIC50	755	nM	IC50	ACS Med Chem Lett (2011) 2: 703-707 [PMID:21984958]
ChEMBL	Inhibition of human recombinant HDAC8 using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by trypsin-coupled fluorogenic assay	B	6.12	pIC50	750	nM	IC50	ACS Med Chem Lett (2012) 3: 749-753 [PMID:24900543]
ChEMBL	Inhibition of HDAC8	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2010) 18: 4103-4110 [PMID:20472442]
GtoPdb	-	-	6.24	pEC50	575	nM	EC50	Biochem J (2008) 409: 581-9 [PMID:17868033]
Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53]
ChEMBL	Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropy	B	5.04	pKi	9200	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3651-3656 [PMID:19457659]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 48 hrs by light microscopic analysis	F	6.7	pIC50	200	nM	IC50	J Nat Prod (2013) 76: 2136-2140 [PMID:24195442]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	7.48	pIC50	33	nM	IC50	J Med Chem (2009) 52: 2185-2187 [PMID:19317450]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]