apicidin [Ligand Id: 7495] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL430060 (Acipidin)
  • coagulation factor III, tissue factor/Coagulation factor III in Human [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
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  • Histone deacetylase in Cryptosporidium parvum [ChEMBL: CHEMBL4740] [UniProtKB: Q9GU59]
  • Histone deacetylase in Plasmodium falciparum [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7]
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  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
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  • histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
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  • histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
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  • histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618]
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  • histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
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  • histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
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  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
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  • Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
coagulation factor III, tissue factor/Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [GtoPdb: 3192] [UniProtKB: P13726]
ChEMBL Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay B 6.7 pIC50 200 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
ChEMBL Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay B 6.82 pIC50 150 nM IC50 J. Biol. Chem. (2007) 282: 28408-28418 [PMID:17675290]
Histone deacetylase in Cryptosporidium parvum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4740] [UniProtKB: Q9GU59]
ChEMBL Binding affinity towards HDAC enzyme derived from Eimeria tenella protozoa B 8.1 pKi 8 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 113-117 [PMID:11206439]
ChEMBL Tested for Histone deacetylase enzyme inhibition assay using Eimeria tenella extract B 9 pIC50 1 nM IC50 J. Med. Chem. (2000) 43: 4919-4922 [PMID:11124001]
Histone deacetylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5541] [UniProtKB: Q9XYC7]
ChEMBL Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells B 9 pIC50 1 nM IC50 J. Med. Chem. (2009) 52: 2185-2187 [PMID:19317450]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL Inhibition of human HDAC1 B 10.4 pKi 0.04 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb - - 10.4 pKi 0.04 nM Ki Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of HDAC1 (mean IC50) B 7.36 pIC50 44 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5948-5952 [PMID:16987657]
ChEMBL Inhibition of HDAC1 B 7.36 pIC50 44 nM IC50 J. Med. Chem. (2008) 51: 2350-2353 [PMID:18370373]
ChEMBL Inhibition of human recombinant C-terminally flag tagged HDAC1 B 7.36 pIC50 44 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5528-5532 [PMID:18809328]
ChEMBL Inhibition of C-terminal FLAG tagged HDAC1 B 7.36 pIC50 44 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3081-3084 [PMID:19410459]
ChEMBL Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay B 7.36 pIC50 44 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3651-3656 [PMID:19457659]
ChEMBL Inhibition of HDAC1 in HEK293 cells B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL Inhibition of HDAC1 (unknown origin) B 7.66 pIC50 22 nM IC50 Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL Inhibition of human recombinant HDAC1 after 30 mins by fluorimetric assay B 7.66 pIC50 22 nM IC50 J. Med. Chem. (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL Inhibition of HDAC1 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry B 7.66 pIC50 22 nM IC50 ACS Med. Chem. Lett. (2011) 2: 703-707 [PMID:21984958]
ChEMBL Inhibition of HDAC1 B 7.89 pIC50 13 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 2549-2554 [PMID:18381239]
ChEMBL Inhibition of human recombinant HDAC1 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay B 7.96 pIC50 11 nM IC50 ACS Med. Chem. Lett. (2012) 3: 749-753 [PMID:24900543]
ChEMBL Inhibition of HDAC1 B 9.15 pIC50 0.7 nM IC50 Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
GtoPdb - - 9.92 pKi 0.12 nM Ki Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of human HDAC2 B 9.92 pKi 0.12 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysis B 7.46 pIC50 35 nM IC50 ACS Med. Chem. Lett. (2012) 3: 505-508 [PMID:24900500]
ChEMBL Inhibition of HDAC2 (unknown origin) B 7.46 pIC50 35 nM IC50 Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL Inhibition of human recombinant HDAC2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay B 7.47 pIC50 34 nM IC50 ACS Med. Chem. Lett. (2012) 3: 749-753 [PMID:24900543]
ChEMBL Inhibition of HDAC2 B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
GtoPdb - - 6.92 pEC50 120 nM EC50 Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL Inhibition of human HDAC3 B 9.59 pKi 0.26 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb - - 9.59 pKi 0.26 nM Ki Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of human recombinant HDAC3 after 30 mins by fluorimetric assay B 7.54 pIC50 29 nM IC50 J. Med. Chem. (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL Inhibition of HDAC3 (unknown origin) B 7.54 pIC50 29 nM IC50 Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL Inhibition of HDAC3 in HEK293 cells B 8.01 pIC50 9.7 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL Inhibition of flag-tagged HDAC3 B 8.6 pIC50 2.5 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL Inhibition of HDAC3 B 9.22 pIC50 0.6 nM IC50 Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
GtoPdb - - 7.37 pEC50 43 nM EC50 Biochem J (2008) 409: 581-9 [PMID:17868033]
GtoPdb - - 7.52 pEC50 30 nM EC50 Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618]
ChEMBL Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay B 8.82 pKi 1.5 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 2809-2812 [PMID:18430569]
GtoPdb - - 9.59 pKi 0.26 nM Ki Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of HDAC3-NCoR2 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry B 7.54 pIC50 29 nM IC50 ACS Med. Chem. Lett. (2011) 2: 703-707 [PMID:21984958]
ChEMBL Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC3/NcoR2 by fluorescence polarization assay B 7.8 pIC50 15.8 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 2809-2812 [PMID:18430569]
ChEMBL Inhibition of human recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay B 7.89 pIC50 13 nM IC50 ACS Med. Chem. Lett. (2012) 3: 749-753 [PMID:24900543]
GtoPdb - - 7.37 pEC50 43 nM EC50 Biochem J (2008) 409: 581-9 [PMID:17868033]
GtoPdb - - 7.52 pEC50 30 nM EC50 Biochem J (2008) 409: 581-9 [PMID:17868033]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL Inhibition of wild type HDAC4 expressed in Escherichia coli B 5.06 pIC50 8700 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL Inhibition of HDAC4 H976Y mutant expressed in Escherichia coli B 5.44 pIC50 3600 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL Inhibition of flag-tagged HDAC4 by pull-down assay B 8.62 pIC50 2.4 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL Inhibition of flag-tagged HDAC4 by Biomol assay B 8.92 pIC50 1.2 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 17335-17340 [PMID:17956988]
ChEMBL Inhibition of flag-tagged HDAC4 B 9 pIC50 1 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 17335-17340 [PMID:17956988]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay B 6.91 pKi 123.4 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 2809-2812 [PMID:18430569]
ChEMBL Inhibition of HDAC6 in human HeLa cells nuclear extract using Fluor-de-Lys as substrate after 30 mins by spectrophotometry B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2011) 2: 703-707 [PMID:21984958]
ChEMBL Inhibition of HDAC6 (unknown origin) B 5 pIC50 >10000 nM IC50 Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL Inhibition of human recombinant HDAC6 after 30 mins by fluorimetric assay B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL Inhibition of human recombinant HDAC6 using Ac-Lys(Ac)-7-amino-4-methylcoumarin as substrate after 30 mins by trypsin-coupled fluorogenic assay B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2012) 3: 749-753 [PMID:24900543]
ChEMBL Inhibition of HDAC6 B 5.02 pIC50 9600 nM IC50 Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
ChEMBL Inhibition of HDAC6 in HEK293 cells B 5.37 pIC50 4300 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1814-1819 [PMID:18308563]
ChEMBL Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from human HDAC6 by fluorescence polarization assay B 6.18 pIC50 665.1 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 2809-2812 [PMID:18430569]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL Activity of human HDAC8 B 7.31 pKi 49 nM Ki Nat. Chem. Biol. (2010) 6: 238-243 [PMID:20139990]
GtoPdb - - 7.31 pKi 49 nM Ki Nat Chem Biol (2010) 6: 238-243 [PMID:20139990]
ChEMBL Inhibition of human recombinant HDAC8 after 30 mins by fluorimetric assay B 6.12 pIC50 760 nM IC50 J. Med. Chem. (2009) 52: 7836-7846 [PMID:19705846]
ChEMBL Inhibition of HDAC8 (unknown origin) B 6.12 pIC50 760 nM IC50 Bioorg Med Chem Lett (2017) 27: 3289-3293 [PMID:28648462]
ChEMBL Inhibition of HDAC8 in human HeLa cells nuclear extract using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by spectrophotometry B 6.12 pIC50 755 nM IC50 ACS Med. Chem. Lett. (2011) 2: 703-707 [PMID:21984958]
ChEMBL Inhibition of human recombinant HDAC8 using Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 30 mins by trypsin-coupled fluorogenic assay B 6.12 pIC50 750 nM IC50 ACS Med. Chem. Lett. (2012) 3: 749-753 [PMID:24900543]
ChEMBL Inhibition of HDAC8 B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. (2010) 18: 4103-4110 [PMID:20472442]
GtoPdb - - 6.24 pEC50 575 nM EC50 Biochem J (2008) 409: 581-9 [PMID:17868033]
Histone deacetylase-like amidohydrolase in Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6017] [UniProtKB: Q70I53]
ChEMBL Displacement of Atto700-HA from Bordetella / Alcaligenes strain FB188 HDAH by fluorescence anisotropy B 5.04 pKi 9200 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 3651-3656 [PMID:19457659]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 48 hrs by light microscopic analysis F 6.7 pIC50 200 nM IC50 J. Nat. Prod. (2013) 76: 2136-2140 [PMID:24195442]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake F 7.48 pIC50 33 nM IC50 J. Med. Chem. (2009) 52: 2185-2187 [PMID:19317450]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]