DSM502 [Ligand Id: 11219] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4633246 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by IonWorks patch clamp electrophysiology assay | B | 4.48 | pEC50 | >33000 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum R1AC1B harboring DHODH C276F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.05 | pEC50 | 89 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 1D3 measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.08 | pEC50 | 83 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum R2B harboring DHODH R265G mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.11 | pEC50 | 78 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum R10C1B harboring DHODH G181C mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.62 | pEC50 | 24 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D70087/N9 infected in po dosed NOD-SCID IL2Rgamma null mouse assessed as reduction in parasitemia administered once daily for 4 days by flow cytometric analysis | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected in human red blood cells after 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasite growth measured after 72 hrs by SYBR Green method | F | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum R1BC1A harboring DHODH L531F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of human Kv1.5 by IonWorks patch clamp electrophysiology assay | B | 4.96 | pEC50 | >11000 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
