DSM502 [Ligand Id: 11219] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4633246 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG by IonWorks patch clamp electrophysiology assay | B | 4.48 | pEC50 | >33000 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum R1AC1B harboring DHODH C276F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.05 | pEC50 | 89 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 1D3 measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.08 | pEC50 | 83 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum R2B harboring DHODH R265G mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.11 | pEC50 | 78 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum R10C1B harboring DHODH G181C mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.62 | pEC50 | 24 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D70087/N9 infected in po dosed NOD-SCID IL2Rgamma null mouse assessed as reduction in parasitemia administered once daily for 4 days by flow cytometric analysis | F | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected in human red blood cells after 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasite growth measured after 72 hrs by SYBR Green method | F | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2021) 64: 6085-6136 [PMID:33876936] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum R1BC1A harboring DHODH L531F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| ChEMBL | Inhibition of human Kv1.5 by IonWorks patch clamp electrophysiology assay | B | 4.96 | pEC50 | >11000 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis. | - | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.85 | pEC50 | 14 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.8 | pEC50 | 16 | nM | EC50 | J Med Chem (2020) 63: 4929-4956 [PMID:32248693] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
