ChEMBL ligand: CHEMBL4633246
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210] Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by IonWorks patch clamp electrophysiology assay	B	4.48	pEC50	>33000	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum R1AC1B harboring DHODH C276F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay	F	7.05	pEC50	89	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against Plasmodium falciparum 1D3 measured after 72 hrs by SYBR Green dye based fluorescence assay	F	7.08	pEC50	83	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against Plasmodium falciparum R2B harboring DHODH R265G mutant measured after 72 hrs by SYBR Green dye based fluorescence assay	F	7.11	pEC50	78	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against Plasmodium falciparum R10C1B harboring DHODH G181C mutant measured after 72 hrs by SYBR Green dye based fluorescence assay	F	7.62	pEC50	24	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green dye based fluorescence assay	F	7.8	pEC50	16	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D70087/N9 infected in po dosed NOD-SCID IL2Rgamma null mouse assessed as reduction in parasitemia administered once daily for 4 days by flow cytometric analysis	F	7.8	pEC50	16	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human red blood cells after 72 hrs by SYBR Green 1 dye based fluorescence assay	F	7.85	pEC50	14	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasite growth measured after 72 hrs by SYBR Green method	F	7.85	pEC50	14	nM	EC50	J Med Chem (2021) 64: 6085-6136 [PMID:33876936]
ChEMBL	Antimalarial activity against Plasmodium falciparum R1BC1A harboring DHODH L531F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay	F	7.89	pEC50	13	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Kv1.5/Voltage-gated potassium channel subunit Kv1.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4306] [GtoPdb: 542] [UniProtKB: P22460]
ChEMBL	Inhibition of human Kv1.5 by IonWorks patch clamp electrophysiology assay	B	4.96	pEC50	>11000	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb	Steady-state kinetic analysis.	-	7.7	pIC50	20	nM	IC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
GtoPdb	Steady-state kinetic analysis.	-	7.85	pIC50	14	nM	IC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
GtoPdb	Parasite growth inhibition assay	-	7.85	pEC50	14	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949]
GtoPdb	Parasite growth inhibition assay	-	7.8	pEC50	16	nM	EC50	J Med Chem (2020) 63: 4929-4956 [PMID:32248693]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]