DSM502 [Ligand Id: 11219] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4633246
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb Steady-state kinetic analysis. - 7.7 pIC50 20 nM IC50 J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
GtoPdb Steady-state kinetic analysis. - 7.85 pIC50 14 nM IC50 J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
GtoPdb Parasite growth inhibition assay - 7.85 pEC50 14 nM EC50 J Med Chem (2020) 63: 4929-4956 [PMID:32248693]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949]
GtoPdb Parasite growth inhibition assay - 7.8 pEC50 16 nM EC50 J Med Chem (2020) 63: 4929-4956 [PMID:32248693]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]