piperaquine [Ligand Id: 10025] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL303933 (Piperaquine)
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
1 CHEMBL303933_lig_chart_1 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
  • This target only has 0 pki data point
2 CHEMBL303933_lig_chart_2 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1
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  • Plasmodium malariae [ChEMBL: CHEMBL613257]
  • This target only has 0 pki data point
3 CHEMBL303933_lig_chart_3 Plasmodium malariae Plasmodium malariae
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  • Plasmodium vivax [ChEMBL: CHEMBL613013]
  • This target only has 0 pki data point
4 CHEMBL303933_lig_chart_4 Plasmodium vivax Plasmodium vivax
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.01 pIC50 98 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S and I356T mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.01 pIC50 98 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay F 7.06 pIC50 88 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL Antimalarial activity against trophozoites stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum F 7.06 pIC50 87.6 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S mutant gene, Pmdr1 S1034C, N1042D mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.08 pIC50 84 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.08 pIC50 84 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 harboring Pfcrt Q271E mutant gene and Ppcrt I371R mutant gene and Pfnhe-1 ms4760 microsatellite mutant assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.09 pIC50 81 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.09 pIC50 81 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.1 pIC50 80 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum PA harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S and I356T mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.1 pIC50 80 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum trophozoites infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 7.11 pIC50 77.2 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.12 pIC50 75 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 harboring Ppcrt M74I, N75E, K76T, A220H, Q271E, N326S and I356T mutant gene, Pmdr1 Y184F, N1042D, D1246Y mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.12 pIC50 75 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 harboring Pfcrt Q271E mutant gene and Ppcrt I371R mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.13 pIC50 74 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.13 pIC50 74 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S and I356T mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.16 pIC50 69 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.16 pIC50 69 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.19 pIC50 64 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S mutant gene, Pmdr1 S1034C, N1042D mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.19 pIC50 64 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy harboring Ppcrt K76T, A220S, N326D and I371R mutant gene, Pmdr1 T184FN, 1042D and D1246Y, mutant gene and Pfmrp H191Y and S437A mutant gene and Pfnhe-1 ms4760 microsatellite mutant assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.2 pIC50 63 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.2 pIC50 63 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.21 pIC50 61 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S mutant gene, Pmdr1 Y184F, S1034C, N1042D, D1246Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.21 pIC50 61 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 harboring Ppcrt I371R mutant gene and Pfnhe-1 ms4760 microsatellite mutant assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.24 pIC50 58 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 harboring Ppcrt I371R mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.24 pIC50 58 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.24 pIC50 58 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.24 pIC50 58 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 harboring Ppcrt I371R mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.25 pIC50 56 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.25 pIC50 56 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum F 7.25 pIC50 56 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 harboring Ppcrt I371R mutant gene and Pfmdr1 Y184F mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.26 pIC50 55 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.26 pIC50 55 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.28 pIC50 53 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S and I356T mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.28 pIC50 53 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.28 pIC50 52 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S and I356T mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.28 pIC50 52 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum RSA11 F 7.29 pIC50 51.38 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum 7G8-mdr7G8 F 7.3 pIC50 49.71 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 7.31 pIC50 49.03 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E mutant gene, Pmdr1 N86Y mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 harboring Ppcrt I371R mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.33 pIC50 47 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 harboring Ppcrt M74I, N75E, K76T, A220S, Q271E mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.33 pIC50 47 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.34 pIC50 46 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S and I356T mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.34 pIC50 46 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.36 pIC50 44 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 harboring Ppcrt I371R mutant gene and Pfnhe-1 ms4760 microsatellite mutant assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.36 pIC50 44 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 after 18 hrs by [3H]hypoxanthine incorporation assay F 7.38 pIC50 42 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum F 7.39 pIC50 41 nM IC50 Eur. J. Med. Chem. (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum F 7.39 pIC50 40.7 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 237-243 [PMID:17967917]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.42 pIC50 38 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol harboring Ppcrt M74I, N75E, K76T, A220S, Q271E, N326S mutant gene, Pmdr1 N86Y mutant gene and Pfmrp H191Y and S437A mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.43 pIC50 37 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.43 pIC50 37 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 F 7.43 pIC50 36.9 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F 7.44 pIC50 36 nM IC50 Eur. J. Med. Chem. (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F 7.45 pIC50 35.5 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 237-243 [PMID:17967917]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.46 pIC50 35 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum clinical isolate after 18 hrs by [3H]hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FC27 F 7.53 pIC50 29.61 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10354 harboring Ppcrt M74I, N75E, K76T, A220S mutant gene, Pmdr1 D1246Y mutant gene assessed as incorporation of [3]H hypoxanthine after 48 hrs by scintillation counter F 7.54 pIC50 29 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.54 pIC50 29 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum 3D7 after 18 hrs by [3H]hypoxanthine incorporation assay F 7.57 pIC50 27 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 106/1 F 7.65 pIC50 22.22 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum T996 F 7.7 pIC50 19.93 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL Antimalarial activity against Plasmodium falciparum infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 7.77 pIC50 17.1 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum 34-1/E F 7.79 pIC50 16.38 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 2265-2267 [PMID:17404003]
ChEMBL In vitro activity against Plasmodium falciparum W-2 F 7.8 pIC50 16 nM IC50 J. Med. Chem. (1992) 35: 2129-2134 [PMID:1597862]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum TM6 infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 7.8 pIC50 15.8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation F 7.84 pIC50 14.6 nM IC50 J. Med. Chem. (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA F 7.84 pIC50 14.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 harboring D10 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 7.92 pIC50 12 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antimalarial activity against Plasmodium falciparum at the ring stage infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 7.93 pIC50 11.8 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimalarial activity against ring stage of Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum F 7.94 pIC50 11.5 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C3 harboring Dd2 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 7.94 pIC50 11.5 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 7.95 pIC50 11.2 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antimalarial activity against Plasmodium falciparum assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 10% human serum F 7.97 pIC50 10.8 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA F 7.98 pIC50 10.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 harboring 7G8 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 7.98 pIC50 10.4 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 7G8 harboring parental pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 8.04 pIC50 9.1 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL In vitro activity against Plasmodium falciparum D6 F 8.08 pIC50 8.3 nM IC50 J. Med. Chem. (1992) 35: 2129-2134 [PMID:1597862]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 8.09 pIC50 8.1 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum C6harboring 7G8 pfcrt allele infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 8.18 pIC50 6.6 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA F 8.2 pIC50 6.26 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against Plasmodium falciparum by ELISA F 8.21 pIC50 6.1 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum C2 infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 8.41 pIC50 3.9 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 8.47 pIC50 3.4 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation F 8.52 pIC50 3 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA F 8.8 pIC50 1.6 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected in human erythrocytes after 72 hrs by ELISA F 7.9 pEC50 12.5 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation by beta counting F 7.09 pIC50 82.06 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 3534-3537 [PMID:19528277]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation F 7.87 pIC50 13.4 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1362-1366 [PMID:19188388]
ChEMBL Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA F 7.9 pIC50 12.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation F 7.96 pIC50 11 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
Plasmodium malariae (target type: ORGANISM) [ChEMBL: CHEMBL613257]
ChEMBL Antimalarial activity against Plasmodium malariae trophozoite stage infected in red blood cells in presence of AB+ human serum by drug susceptibility assay F 7.42 pIC50 38.4 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 197-202 [PMID:20937779]
ChEMBL Antimalarial activity against Plasmodium malariae ring stage infected in red blood cells in presence of AB+ human serum by drug susceptibility assay F 7.54 pIC50 29 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 197-202 [PMID:20937779]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL Antimicrobial activity against Plasmodium vivax at the ring stage measured within 30 hrs by microscopy F 7.51 pIC50 31.2 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimicrobial activity against Plasmodium vivax trophozoites measured after 30 hrs by microscopy F 7.54 pIC50 29.1 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimalarial activity against Plasmodium vivax infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 7.61 pIC50 24.8 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimicrobial activity against Plasmodium vivax trophozoites measured within 30 hrs by microscopy F 7.64 pIC50 22.9 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimalarial activity against Plasmodium vivax trophozoites infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 7.66 pIC50 21.7 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimalarial activity against Plasmodium vivax with >50% parasites at ring stage infected in human erythrocytes assessed as growth inhibition after 30 to 50 hrs by microscopic analysis using giemsa staining F 7.71 pIC50 19.6 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium vivax by Giemsa staining F 7.76 pIC50 17.5 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1094-1099 [PMID:19104023]
ChEMBL Antimalarial activity against trophozoites stage of Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum F 7.8 pIC50 15.9 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimalarial activity against ring stage of Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum F 7.81 pIC50 15.5 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]
ChEMBL Antimicrobial activity against Plasmodium vivax at the ring stage measured after 30 hrs by microscopy F 7.84 pIC50 14.6 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimalarial activity against Plasmodium vivax at the ring stage infected in human erythrocytes assessed as growth inhibition by microscopic analysis using giemsa staining F 7.85 pIC50 14 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 5146-5150 [PMID:20876370]
ChEMBL Antimalarial activity against Plasmodium vivax assessed as parasites growth inhibition using giemsa staining after 24 to 56 hrs by microscopic analysis in presence of 20% human serum F 7.88 pIC50 13.2 nM IC50 Antimicrob. Agents Chemother. (2011) 55: 961-966 [PMID:21135175]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]