TCMDC-125163 [Ligand Id: 10339] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL527419 (TCMDC-125163)
  • Glucose transporter in Leishmania mexicana [ChEMBL: CHEMBL3431938] [UniProtKB: O61059]
  • Glucose transporter 1/Glucose transporter in Human [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166]
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  • Hexose transporter 1 in Plasmodium falciparum [ChEMBL: CHEMBL4697] [UniProtKB: O97467]
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  • Plasmodium falciparum hexose transporter in Plasmodium falciparum K1 [GtoPdb: 3069]
  • Plasmodium falciparum hexose transporter in Plasmodium falciparum 3D7 [GtoPdb: 3069] [UniProtKB: Q7KWJ5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Glucose transporter in Leishmania mexicana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3431938] [UniProtKB: O61059]
ChEMBL ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro F 4.64 pIC50 >23000 nM IC50 St. Jude Leishmania screening dataset.
Glucose transporter 1/Glucose transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166]
ChEMBL ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro F 4.79 pIC50 16313 nM IC50 St. Jude Leishmania screening dataset.
Hexose transporter 1 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4697] [UniProtKB: O97467]
ChEMBL ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro F 4.94 pIC50 11452 nM IC50 St. Jude Leishmania screening dataset.
Plasmodium falciparum hexose transporter in Plasmodium falciparum K1 [GtoPdb: 3069]
GtoPdb Parasite growth inhibition assay - 6.01 pEC50 970 nM EC50 PLoS ONE (2015) 10: e0123598 [PMID:25894322]
Plasmodium falciparum hexose transporter in Plasmodium falciparum 3D7 [GtoPdb: 3069] [UniProtKB: Q7KWJ5]
GtoPdb Parasite growth inhibition assay - 5.85 pEC50 1400 nM EC50 PLoS ONE (2015) 10: e0123598 [PMID:25894322]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]