artemisinin [Ligand Id: 9954] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL269671
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells F 4.92 pIC50 12000 nM IC50 J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL Antimalarial activity against Plasmodium berghei F 8.05 pIC50 8.9 nM IC50 J Med Chem (2018) 61: 5822-5880 [PMID:29400967]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 after 72 hrs by LDH assay F 6.85 pIC50 140 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2084-2087 [PMID:26965857]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay F 7.03 pIC50 94 nM IC50 Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay F 7.03 pIC50 94 nM IC50 Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL Antiplasmodial activity against IEF stage of Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method F 7.1 pIC50 80 nM IC50 J Nat Prod (2018) 81: 2682-2691 [PMID:30565934]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 F 7.1 pIC50 80 nM IC50 Eur J Med Chem (2019) 180: 562-612 [PMID:31344615]
ChEMBL Antiplasmodial activity against chloroquine-susceptible blood forms of Plasmodium falciparum 3D7 infected in human erythrocytes measured after 48 hrs by SYBR green1 staining based fluorescence assay F 7.13 pIC50 74 nM IC50 Bioorg Med Chem (2018) 26: 3837-3844 [PMID:29983285]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.27 pIC50 54 nM IC50 J Med Chem (2019) 62: 3503-3512 [PMID:30856324]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay F 7.35 pIC50 45 nM IC50 Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by YOYO-1 dye-based flow cytometry F 7.49 pIC50 32.1 nM IC50 Eur J Med Chem (2017) 138: 993-1001 [PMID:28756265]
ChEMBL Antimalarial activity against synchronized ring stage CQ-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry F 7.49 pIC50 32 nM IC50 J Med Chem (2019) 62: 5562-5578 [PMID:31062592]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay F 7.54 pIC50 29 nM IC50 MedChemComm (2015) 6: 357-362
ChEMBL Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay F 7.6 pIC50 25 nM IC50 J Nat Prod (2017) 80: 3120-3127 [PMID:29182338]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay F 7.6 pIC50 25 nM IC50 Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay F 7.64 pIC50 23 nM IC50 Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL Antimalarial activity against synchronized ring stage CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry F 7.68 pIC50 21 nM IC50 J Med Chem (2019) 62: 5562-5578 [PMID:31062592]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay F 7.72 pIC50 19 nM IC50 Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay F 7.72 pIC50 19 nM IC50 Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC after 72 hrs by LDH release assay F 7.77 pIC50 17.1 nM IC50 Eur J Med Chem (2019) 162: 277-289 [PMID:30448417]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes F 7.79 pIC50 16.3 nM IC50 Bioorg Med Chem Lett (2018) 28: 265-272
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC after 72 hrs by LDH release assay F 7.79 pIC50 16.2 nM IC50 Eur J Med Chem (2019) 162: 277-289 [PMID:30448417]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by YOYO1 probe-based flow cytometric method F 7.82 pIC50 15 nM IC50 Bioorg Med Chem Lett (2017) 27: 1693-1697 [PMID:28318947]
ChEMBL Antiplasmodial activity against synchronized ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay F 7.82 pIC50 15 nM IC50 Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum INDO infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay F 7.82 pIC50 15 nM IC50 Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay F 7.85 pIC50 14 nM IC50 Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL Antimalarial activity against mutidrug resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay F 7.89 pIC50 13 nM IC50 J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay F 7.89 pIC50 13 nM IC50 Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 dye based assay F 7.92 pIC50 12.1 nM IC50 Bioorg Med Chem Lett (2018) 28: 40-42 [PMID:29162457]
ChEMBL Antiplasmodial activity against ring-stage chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite viability after 72 hrs by SYBR Green I dye-based assay F 7.92 pIC50 12 nM IC50 Bioorg Med Chem Lett (2018) 28: 3368-3371 [PMID:30219526]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay F 7.92 pIC50 12 nM IC50 MedChemComm (2015) 6: 357-362
ChEMBL Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures by PicoGreen dye based assay F 7.98 pIC50 10.4 nM IC50 J Med Chem (2018) 61: 8847-8858 [PMID:30192536]
ChEMBL Antiplasmodial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 schizonts infected in human erythrocytes assessed as inhibition of parasite invasion after 24 hrs by Diff-Quick staining based microscopic analysis F 8 pIC50 10 nM IC50 Bioorg Med Chem Lett (2016) 26: 5007-5008 [PMID:27623546]
ChEMBL Antiplasmodial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay F 8 pIC50 10 nM IC50 J Nat Prod (2017) 80: 1750-1757 [PMID:28557449]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability incubated for 48 hrs by APAD colorimetric test F 8 pIC50 10 nM IC50 J Nat Prod (2019) 82: 1361-1366 [PMID:30943031]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 incubated for 72 hours by DAPI-staining based confocal imaging analysis F 8.05 pIC50 9 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3326-3329 [PMID:27212070]
ChEMBL Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green1 dye based fluorescence assay F 8.05 pIC50 9 nM IC50 J Nat Prod (2018) 81: 475-483 [PMID:29048892]
ChEMBL Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay F 8.05 pIC50 9 nM IC50 Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability incubated for 72 hrs by SYBR Green I dye based assay F 8.07 pIC50 8.5 nM IC50 J Nat Prod (2019) 82: 431-439 [PMID:30354100]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability incubated for 72 hrs by SYBR Green I dye based assay F 8.07 pIC50 8.5 nM IC50 J Nat Prod (2019) 82: 431-439 [PMID:30354100]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 ring stage parasite assessed as decrease in parasite viability after 72 hrs by SYBR green 1 dye based assay F 8.07 pIC50 8.5 nM IC50 J Nat Prod (2018) 81: 1260-1265 [PMID:29738243]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I dye-based assay F 8.15 pIC50 7 nM IC50 J Nat Prod (2017) 80: 1639-1647 [PMID:28463001]
ChEMBL Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay F 8.15 pIC50 7 nM IC50 J Med Chem (2019) 62: 1330-1347 [PMID:30615444]
ChEMBL Antiplasmodial activity against ring-stage of chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye-based flow cytometric method F 8.15 pIC50 7 nM IC50 Eur J Med Chem (2018) 143: 150-156 [PMID:29174811]
ChEMBL Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay F 8.15 pIC50 7 nM IC50 J Med Chem (2019) 62: 1330-1347 [PMID:30615444]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay F 8.15 pIC50 7 nM IC50 J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 erythrocytic stages incubated for 48 hrs by [3H]-hypoxanthine incorporation assay F 8.19 pIC50 6.4 nM IC50 Bioorg Med Chem (2019) 27: 2052-2065 [PMID:30962114]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay F 8.21 pIC50 6.2 nM IC50 Bioorg. Med. Chem. (2016) 24: 2544-2548 [PMID:27112454]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by YOYO-1 dye based flow cytometric analysis F 8.22 pIC50 6 nM IC50 J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay F 8.23 pIC50 5.9 nM IC50 Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491]
ChEMBL Antimalarial activity against mid-ring stage of Plasmodium falciparum Fab9 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay F 8.28 pIC50 5.2 nM IC50 Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL Antimalarial activity against mid-ring stage of multidrug-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay F 8.39 pIC50 4.1 nM IC50 Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 erythrocytic stage assessed as reduction in parasitic LDH activity measured after 48 hrs by colorimetric method F 8.4 pIC50 4 nM IC50 J Nat Prod (2017) 80: 1404-1410 [PMID:28368118]
ChEMBL Antimalarial activity against ring-stage chloroquine-susceptible Plasmodium falciparum 3D7 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis F 8.4 pIC50 4 nM IC50 Eur J Med Chem (2019) 163: 404-412 [PMID:30530192]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green 1 assay F 8.4 pIC50 4 nM IC50 J Nat Prod (2017) 80: 96-107 [PMID:27997206]
ChEMBL Antimalarial activity against ring-stage chloroquine-susceptible Plasmodium falciparum 3D7 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis F 8.4 pIC50 4 nM IC50 Eur J Med Chem (2019) 163: 404-412 [PMID:30530192]
ChEMBL Antiplasmodial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay F 8.4 pIC50 4 nM IC50 J Nat Prod (2017) 80: 1750-1757 [PMID:28557449]
ChEMBL Antimalarial activity against ring-stage multidrug-resistant Plasmodium falciparum Dd2 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis F 8.6 pIC50 2.5 nM IC50 Eur J Med Chem (2019) 163: 404-412 [PMID:30530192]
ChEMBL Antimalarial activity against ring-stage multidrug-resistant Plasmodium falciparum Dd2 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis F 8.6 pIC50 2.5 nM IC50 Eur J Med Chem (2019) 163: 404-412 [PMID:30530192]
ChEMBL Antimalarial activity against mid-ring stage of Plasmodium falciparum GB4 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay F 8.66 pIC50 2.2 nM IC50 Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL Antiparasitic activity against Plasmodium falciparum W2 after 48 hrs by YOYO-1 probe-based flow cytometry F 7.64 pEC50 23 nM EC50 J Med Chem (2017) 60: 6911-6923 [PMID:28763614]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation pretreated for 24 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method F 7.7 pEC50 20 nM EC50 ACS Med Chem Lett (2019) 10: 137-141 [PMID:30655961]
ChEMBL Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 3 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay F 7.89 pEC50 13 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antiplasmodial activity against chloroquine resistant Plasmodium falciparum W2 erythrocytic ring stage after 48 hrs using hypoxanthine by flow cytometric analysis F 8 pEC50 10 nM EC50 Eur J Med Chem (2018) 149: 69-78 [PMID:29499488]
ChEMBL Antiplasmodium activity against Plasmodium falciparum W2 by flow cytometry F 8.03 pEC50 9.3 nM EC50 ACS Med. Chem. Lett. (2015) 6: 1145-1149 [PMID:26617969]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay F 8.1 pEC50 8 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay F 8.22 pEC50 6 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 6 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay F 8.3 pEC50 5 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 24 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay F 8.7 pEC50 2 nM EC50 J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hours by DAPI-staining based confocal imaging analysis F 8.11 pIC50 7.75 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3326-3329 [PMID:27212070]
Plasmodium falciparum D6 (target type: ORGANISM) [ChEMBL: CHEMBL2367107]
ChEMBL Antimalarial activity against chloroquine sensitive Plasmodium falciparum D6 after 72 hrs by LDH assay F 7.15 pIC50 71 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2084-2087 [PMID:26965857]
ChEMBL Antimalarial activity against chloroquine-susceptible Plasmodium falciparum D6 after 48 hrs by [3H]hypoxanthine incorporation assay F 8.05 pIC50 9 nM IC50 J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against chloroquine/pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay F 8.19 pIC50 6.4 nM IC50 Bioorg. Med. Chem. (2016) 24: 3781-3789 [PMID:27344215]
ChEMBL Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method F 8.19 pIC50 6.4 nM IC50 Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]