artemisinin [Ligand Id: 9954] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL269671 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
| ChEMBL | Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells | F | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | Antimalarial activity against Plasmodium berghei | F | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (2018) 61: 5822-5880 [PMID:29400967] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2019) 166: 206-223 [PMID:30711831] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 after 72 hrs by LDH assay | F | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2084-2087 [PMID:26965857] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay | F | 7.03 | pIC50 | 94 | nM | IC50 | Eur J Med Chem (2018) 143: 866-880 [PMID:29223887] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay | F | 7.03 | pIC50 | 94 | nM | IC50 | Eur J Med Chem (2018) 143: 866-880 [PMID:29223887] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 | F | 7.1 | pIC50 | 80 | nM | IC50 | Eur J Med Chem (2019) 180: 562-612 [PMID:31344615] |
| ChEMBL | Antiplasmodial activity against IEF stage of Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method | F | 7.1 | pIC50 | 80 | nM | IC50 | J Nat Prod (2018) 81: 2682-2691 [PMID:30565934] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible blood forms of Plasmodium falciparum 3D7 infected in human erythrocytes measured after 48 hrs by SYBR green1 staining based fluorescence assay | F | 7.13 | pIC50 | 74 | nM | IC50 | Bioorg Med Chem (2018) 26: 3837-3844 [PMID:29983285] |
| ChEMBL | Antiplasmodial activity against chloroquine resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes preincubated for 24 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation analysis | F | 7.26 | pIC50 | 55 | nM | IC50 | ACS Med Chem Lett (2020) 11: 921-927 [PMID:32435406] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.27 | pIC50 | 54 | nM | IC50 | J Med Chem (2019) 62: 3503-3512 [PMID:30856324] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay | F | 7.35 | pIC50 | 45 | nM | IC50 | Eur J Med Chem (2017) 129: 175-185 [PMID:28222317] |
| ChEMBL | Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay | F | 7.48 | pIC50 | 33 | nM | IC50 | ACS Med Chem Lett (2019) 10: 966-971 [PMID:31223456] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by YOYO-1 dye-based flow cytometry | F | 7.49 | pIC50 | 32.1 | nM | IC50 | Eur J Med Chem (2017) 138: 993-1001 [PMID:28756265] |
| ChEMBL | Antimalarial activity against synchronized ring stage CQ-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry | F | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (2019) 62: 5562-5578 [PMID:31062592] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | F | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2019) 166: 206-223 [PMID:30711831] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay | F | 7.54 | pIC50 | 29 | nM | IC50 | Medchemcomm (2015) 6: 357-362 |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay | F | 7.6 | pIC50 | 25 | nM | IC50 | J Nat Prod (2017) 80: 3120-3127 [PMID:29182338] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay | F | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2017) 126: 675-686 [PMID:27936446] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum 3D7 incubated for 50 hrs | F | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127037-127037 [PMID:32081449] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay | F | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2017) 129: 175-185 [PMID:28222317] |
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 | F | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127037-127037 [PMID:32081449] |
| ChEMBL | Antimalarial activity against synchronized ring stage CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry | F | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2019) 62: 5562-5578 [PMID:31062592] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay | F | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2017) 139: 22-47 [PMID:28800458] |
| ChEMBL | Antimalarial activity against wild-type Plasmodium falcipuram 3D7 assessed as growth inhibition | F | 7.72 | pIC50 | 19 | nM | IC50 | J Nat Prod (2022) 85: 63-69 [PMID:34949088] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay | F | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2017) 139: 22-47 [PMID:28800458] |
| ChEMBL | Antimalarial activity against artemisinin-sensitive Plasmodium falciparum F32-TEM by SYBR green dye based fluorescence assay | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2021) 39: 127884-127884 [PMID:33636304] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC after 72 hrs by LDH release assay | F | 7.77 | pIC50 | 17.1 | nM | IC50 | Eur J Med Chem (2019) 162: 277-289 [PMID:30448417] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes | F | 7.79 | pIC50 | 16.3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 265-272 [PMID:29326018] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC after 72 hrs by LDH release assay | F | 7.79 | pIC50 | 16.2 | nM | IC50 | Eur J Med Chem (2019) 162: 277-289 [PMID:30448417] |
| ChEMBL | Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum INDO infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Eur J Med Chem (2018) 155: 623-638 [PMID:29929118] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by YOYO1 probe-based flow cytometric method | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1693-1697 [PMID:28318947] |
| ChEMBL | Antiplasmodial activity against synchronized ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Eur J Med Chem (2018) 155: 623-638 [PMID:29929118] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay | F | 7.85 | pIC50 | 14 | nM | IC50 | Eur J Med Chem (2017) 126: 675-686 [PMID:27936446] |
| ChEMBL | Antiplasmodial activity against artemisinin-resistant Plasmodium falciparum Cam 3.1 R539 assessed as growth inhibition by SYBER green 1 dye based fluorescence assay | F | 7.87 | pIC50 | 13.48 | nM | IC50 | Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874] |
| ChEMBL | Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2018) 155: 623-638 [PMID:29929118] |
| ChEMBL | Antimalarial activity against mutidrug resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive ring-stage Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green1 dye-based assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Nat Prod (2020) 83: 1751-1765 [PMID:32468815] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 dye based assay | F | 7.92 | pIC50 | 12.1 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 40-42 [PMID:29162457] |
| ChEMBL | Antiplasmodial activity against ring-stage chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite viability after 72 hrs by SYBR Green I dye-based assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3368-3371 [PMID:30219526] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Medchemcomm (2015) 6: 357-362 |
| ChEMBL | Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures by PicoGreen dye based assay | F | 7.98 | pIC50 | 10.4 | nM | IC50 | J Med Chem (2018) 61: 8847-8858 [PMID:30192536] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Palo Alto(CQR)Ouganda incubated for 48 hrs by classical radioactive microdilution method | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability incubated for 48 hrs by APAD colorimetric test | F | 8 | pIC50 | 10 | nM | IC50 | J Nat Prod (2019) 82: 1361-1366 [PMID:30943031] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 schizonts infected in human erythrocytes assessed as inhibition of parasite invasion after 24 hrs by Diff-Quick staining based microscopic analysis | F | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 5007-5008 [PMID:27623546] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1(CQR)Colombia incubated for 48 hrs by classical radioactive microdilution method | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2(CQR)Indo-China incubated for 48 hrs by classical radioactive microdilution method | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay | F | 8 | pIC50 | 10 | nM | IC50 | J Nat Prod (2017) 80: 1750-1757 [PMID:28557449] |
| ChEMBL | Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green1 dye based fluorescence assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Nat Prod (2018) 81: 475-483 [PMID:29048892] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 incubated for 72 hours by DAPI-staining based confocal imaging analysis | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3326-3329 [PMID:27212070] |
| ChEMBL | Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability incubated for 72 hrs by SYBR Green I dye based assay | F | 8.07 | pIC50 | 8.5 | nM | IC50 | J Nat Prod (2019) 82: 431-439 [PMID:30354100] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 ring stage parasite assessed as decrease in parasite viability after 72 hrs by SYBR green 1 dye based assay | F | 8.07 | pIC50 | 8.5 | nM | IC50 | J Nat Prod (2018) 81: 1260-1265 [PMID:29738243] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29(CQR)Cameroon incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I dye-based assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Nat Prod (2017) 80: 1639-1647 [PMID:28463001] |
| ChEMBL | Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2019) 62: 1330-1347 [PMID:30615444] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | Antiplasmodial activity against ring-stage of chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye-based flow cytometric method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2018) 143: 150-156 [PMID:29174811] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcR3(CQR)Gambia incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6(CQS)Sierra Leone incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32(CQS)Tanzania incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum INDO assessed as growth inhibition by SYBER green 1 dye based fluorescence assay | F | 8.18 | pIC50 | 6.6 | nM | IC50 | Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR Green 1 staining based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Nat Prod (2020) 83: 569-577 [PMID:31577436] |
| ChEMBL | Antiplasmodial activity against ring stage Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR Green 1 staining based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Nat Prod (2020) 83: 1043-1050 [PMID:32227943] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 erythrocytic stages incubated for 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2019) 27: 2052-2065 [PMID:30962114] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay | F | 8.21 | pIC50 | 6.2 | nM | IC50 | Bioorg Med Chem (2016) 24: 2544-2548 [PMID:27112454] |
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum 3D7 assessed as reduction in schizont maturation incubated for 24 hrs by Giemsa staining based assay | F | 8.22 | pIC50 | 6 | nM | IC50 | RSC Med Chem (2020) 11: 184-211 [PMID:33479627] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by YOYO-1 dye based flow cytometric analysis | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2017) 60: 5889-5908 [PMID:28635296] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay | F | 8.23 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491] |
| ChEMBL | Antimalarial activity against mid-ring stage of Plasmodium falciparum Fab9 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 8.28 | pIC50 | 5.2 | nM | IC50 | Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368] |
| ChEMBL | Antimalarial activity against mid-ring stage of multidrug-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368] |
| ChEMBL | Antimalarial activity against ring-stage chloroquine-susceptible Plasmodium falciparum 3D7 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis | F | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2019) 163: 404-412 [PMID:30530192] |
| ChEMBL | Antiplasmodial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay | F | 8.4 | pIC50 | 4 | nM | IC50 | J Nat Prod (2017) 80: 1750-1757 [PMID:28557449] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 erythrocytic stage assessed as reduction in parasitic LDH activity measured after 48 hrs by colorimetric method | F | 8.4 | pIC50 | 4 | nM | IC50 | J Nat Prod (2017) 80: 1404-1410 [PMID:28368118] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green 1 assay | F | 8.4 | pIC50 | 4 | nM | IC50 | J Nat Prod (2017) 80: 96-107 [PMID:27997206] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 strain | F | 8.47 | pIC50 | 3.4 | nM | IC50 | Eur J Med Chem (2021) 210: 112969-112969 [PMID:33148495] |
| ChEMBL | Antimalarial activity against ring-stage multidrug-resistant Plasmodium falciparum Dd2 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis | F | 8.6 | pIC50 | 2.5 | nM | IC50 | Eur J Med Chem (2019) 163: 404-412 [PMID:30530192] |
| ChEMBL | Antimalarial activity against mid-ring stage of Plasmodium falciparum GB4 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 8.66 | pIC50 | 2.2 | nM | IC50 | Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | F | 7.57 | pEC50 | 27 | nM | EC50 | Eur J Med Chem (2021) 220: 113454-113454 [PMID:33901900] |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum W2 after 48 hrs by YOYO-1 probe-based flow cytometry | F | 7.64 | pEC50 | 23 | nM | EC50 | J Med Chem (2017) 60: 6911-6923 [PMID:28763614] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation pretreated for 24 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method | F | 7.7 | pEC50 | 20 | nM | EC50 | ACS Med Chem Lett (2019) 10: 137-141 [PMID:30655961] |
| ChEMBL | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum 7G8 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | F | 7.74 | pEC50 | 18 | nM | EC50 | Eur J Med Chem (2021) 220: 113454-113454 [PMID:33901900] |
| ChEMBL | Antimalarial activity against chloroquine, pyrimethamine and mefloquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | F | 7.82 | pEC50 | 15 | nM | EC50 | Eur J Med Chem (2021) 220: 113454-113454 [PMID:33901900] |
| ChEMBL | Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 3 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and mefloquine-resistant asexual blood stage of Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR green I staining based fluorescence assay | F | 7.96 | pEC50 | 11 | nM | EC50 | ACS Med Chem Lett (2022) 13: 371-376 [PMID:35300082] |
| ChEMBL | Antiplasmodial activity against chloroquine resistant Plasmodium falciparum W2 erythrocytic ring stage after 48 hrs using hypoxanthine by flow cytometric analysis | F | 8 | pEC50 | 10 | nM | EC50 | Eur J Med Chem (2018) 149: 69-78 [PMID:29499488] |
| ChEMBL | Antiplasmodium activity against Plasmodium falciparum W2 by flow cytometry | F | 8.03 | pEC50 | 9.3 | nM | EC50 | ACS Med Chem Lett (2015) 6: 1145-1149 [PMID:26617969] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay | F | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 6 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay | F | 8.3 | pEC50 | 5 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 24 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay | F | 8.7 | pEC50 | 2 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocytes transfected with GFP-LUC assessed as growth inhibition incubated for 72 hrs by mitotracker Red-CMXROS dye based fluorescence microscopic analysis | F | 9.1 | pEC50 | 0.8 | nM | EC50 | J Med Chem (2016) 59: 9672-9685 [PMID:27631715] |
| Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hours by DAPI-staining based confocal imaging analysis | F | 8.11 | pIC50 | 7.75 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3326-3329 [PMID:27212070] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and mefloquine-sensitive asexual blood stage of Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green I staining based fluorescence assay | F | 8 | pEC50 | 10 | nM | EC50 | ACS Med Chem Lett (2022) 13: 371-376 [PMID:35300082] |
| Plasmodium falciparum D6 (target type: ORGANISM) [ChEMBL: CHEMBL2367107] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum D6 after 72 hrs by LDH assay | F | 7.15 | pIC50 | 71 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2084-2087 [PMID:26965857] |
| ChEMBL | Antimalarial activity against chloroquine-susceptible Plasmodium falciparum D6 after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine/pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2016) 24: 3781-3789 [PMID:27344215] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
