ChEMBL ligand: CHEMBL269671
Plasmodium berghei [ChEMBL: CHEMBL612653] This target only has 0 pki data point 1 CHEMBL269671_lig_chart_1 Plasmodium berghei Plasmodium berghei There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] This target only has 0 pki data point 2 CHEMBL269671_lig_chart_2 Plasmodium falciparum Plasmodium falciparum There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] This target only has 0 pki data point 3 CHEMBL269671_lig_chart_3 Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum D6 [ChEMBL: CHEMBL2367107] This target only has 0 pki data point 4 CHEMBL269671_lig_chart_4 Plasmodium falciparum D6 Plasmodium falciparum D6 There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] This target only has 0 pki data point 5 CHEMBL269671_lig_chart_5 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1 There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells	F	4.92	pIC50	12000	nM	IC50	J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 after 72 hrs by LDH assay	F	6.85	pIC50	140	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 2084-2087 [PMID:26965857]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay	F	7.03	pIC50	94	nM	IC50	Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay	F	7.03	pIC50	94	nM	IC50	Eur J Med Chem (2018) 143: 866-880 [PMID:29223887]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible blood forms of Plasmodium falciparum 3D7 infected in human erythrocytes measured after 48 hrs by SYBR green1 staining based fluorescence assay	F	7.13	pIC50	74	nM	IC50	Bioorg Med Chem (2018) 26: 3837-3844 [PMID:29983285]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	7.35	pIC50	45	nM	IC50	Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by YOYO-1 dye-based flow cytometry	F	7.49	pIC50	32.1	nM	IC50	Eur J Med Chem (2017) 138: 993-1001 [PMID:28756265]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	7.54	pIC50	29	nM	IC50	MedChemComm (2015) 6: 357-362
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay	F	7.6	pIC50	25	nM	IC50	J Nat Prod (2017) 80: 3120-3127 [PMID:29182338]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay	F	7.6	pIC50	25	nM	IC50	Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay	F	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2017) 129: 175-185 [PMID:28222317]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7.72	pIC50	19	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay	F	7.72	pIC50	19	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes	F	7.79	pIC50	16.3	nM	IC50	Bioorg Med Chem Lett (2018) 28: 265-272
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by YOYO1 probe-based flow cytometric method	F	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1693-1697 [PMID:28318947]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum INDO infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay	F	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2017) 126: 675-686 [PMID:27936446]
ChEMBL	Antimalarial activity against mutidrug resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay	F	7.89	pIC50	13	nM	IC50	J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay	F	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2018) 155: 623-638 [PMID:29929118]
ChEMBL	Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 dye based assay	F	7.92	pIC50	12.1	nM	IC50	Bioorg Med Chem Lett (2018) 28: 40-42 [PMID:29162457]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay	F	7.92	pIC50	12	nM	IC50	MedChemComm (2015) 6: 357-362
ChEMBL	Antiplasmodial activity against ring-stage chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite viability after 72 hrs by SYBR Green I dye-based assay	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2018) 28: 3368-3371 [PMID:30219526]
ChEMBL	Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures by PicoGreen dye based assay	F	7.98	pIC50	10.4	nM	IC50	J Med Chem (2018) 61: 8847-8858 [PMID:30192536]
ChEMBL	Antiplasmodial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay	F	8	pIC50	10	nM	IC50	J Nat Prod (2017) 80: 1750-1757 [PMID:28557449]
ChEMBL	Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green1 dye based fluorescence assay	F	8.05	pIC50	9	nM	IC50	J Nat Prod (2018) 81: 475-483 [PMID:29048892]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 incubated for 72 hours by DAPI-staining based confocal imaging analysis	F	8.05	pIC50	9	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 3326-3329 [PMID:27212070]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay	F	8.05	pIC50	9	nM	IC50	Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 ring stage parasite assessed as decrease in parasite viability after 72 hrs by SYBR green 1 dye based assay	F	8.07	pIC50	8.5	nM	IC50	J Nat Prod (2018) 81: 1260-1265 [PMID:29738243]
ChEMBL	Antiplasmodial activity against ring-stage of chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye-based flow cytometric method	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2018) 143: 150-156 [PMID:29174811]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.15	pIC50	7	nM	IC50	J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I dye-based assay	F	8.15	pIC50	7	nM	IC50	J Nat Prod (2017) 80: 1639-1647 [PMID:28463001]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay	F	8.21	pIC50	6.2	nM	IC50	Bioorg. Med. Chem. (2016) 24: 2544-2548 [PMID:27112454]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by YOYO-1 dye based flow cytometric analysis	F	8.22	pIC50	6	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay	F	8.23	pIC50	5.9	nM	IC50	Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491]
ChEMBL	Antimalarial activity against mid-ring stage of Plasmodium falciparum Fab9 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay	F	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL	Antimalarial activity against mid-ring stage of multidrug-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay	F	8.39	pIC50	4.1	nM	IC50	Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 erythrocytic stage assessed as reduction in parasitic LDH activity measured after 48 hrs by colorimetric method	F	8.4	pIC50	4	nM	IC50	J Nat Prod (2017) 80: 1404-1410 [PMID:28368118]
ChEMBL	Antiplasmodial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay	F	8.4	pIC50	4	nM	IC50	J Nat Prod (2017) 80: 1750-1757 [PMID:28557449]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green 1 assay	F	8.4	pIC50	4	nM	IC50	J Nat Prod (2017) 80: 96-107 [PMID:27997206]
ChEMBL	Antimalarial activity against mid-ring stage of Plasmodium falciparum GB4 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay	F	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL	Antiparasitic activity against Plasmodium falciparum W2 after 48 hrs by YOYO-1 probe-based flow cytometry	F	7.64	pEC50	23	nM	EC50	J Med Chem (2017) 60: 6911-6923 [PMID:28763614]
ChEMBL	Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 3 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay	F	7.89	pEC50	13	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antiplasmodial activity against chloroquine resistant Plasmodium falciparum W2 erythrocytic ring stage after 48 hrs using hypoxanthine by flow cytometric analysis	F	8	pEC50	10	nM	EC50	Eur J Med Chem (2018) 149: 69-78 [PMID:29499488]
ChEMBL	Antiplasmodium activity against Plasmodium falciparum W2 by flow cytometry	F	8.03	pEC50	9.3	nM	EC50	ACS Med. Chem. Lett. (2015) 6: 1145-1149 [PMID:26617969]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay	F	8.1	pEC50	8	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay	F	8.22	pEC50	6	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 6 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay	F	8.3	pEC50	5	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
ChEMBL	Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 24 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay	F	8.7	pEC50	2	nM	EC50	J Med Chem (2017) 60: 1171-1188 [PMID:28080063]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hours by DAPI-staining based confocal imaging analysis	F	8.11	pIC50	7.75	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 3326-3329 [PMID:27212070]
Plasmodium falciparum D6 (target type: ORGANISM) [ChEMBL: CHEMBL2367107]
ChEMBL	Antimalarial activity against chloroquine sensitive Plasmodium falciparum D6 after 72 hrs by LDH assay	F	7.15	pIC50	71	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 2084-2087 [PMID:26965857]
ChEMBL	Antimalarial activity against chloroquine-susceptible Plasmodium falciparum D6 after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.05	pIC50	9	nM	IC50	J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antiplasmodial activity against chloroquine/pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.19	pIC50	6.4	nM	IC50	Bioorg. Med. Chem. (2016) 24: 3781-3789 [PMID:27344215]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method	F	8.19	pIC50	6.4	nM	IC50	Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]