artemisinin [Ligand Id: 9954] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL269671 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.7 | pIC50 | 2000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Dihydroorotate dehydrogenase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3486] [UniProtKB: Q54A96] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum DHOD | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 972-975 [PMID:19097788] |
| Dihydroorotate dehydrogenase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5621] [UniProtKB: P28272] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae DHOD | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 972-975 [PMID:19097788] |
| Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
| ChEMBL | Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells | F | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | Antimalarial activity against liver stage of Plasmodium berghei infected in human Huh7 cells after 48 hrs by luciferase assay | F | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2014) 5: 108-112 [PMID:24900781] |
| ChEMBL | Inhibitory concentration against Plasmodium berghei | F | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 2945-2964 [PMID:15163175] |
| ChEMBL | Antimalarial activity against Plasmodium berghei in mice (Mus musculus) | F | 8.03 | pIC50 | 9.4 | nM | IC50 | J Med Chem (2002) 45: 3824-3828 [PMID:12190305] |
| ChEMBL | Antimalarial activity against Plasmodium berghei | F | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (2018) 61: 5822-5880 [PMID:29400967] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | OSM: Inhibition of Plasmodium falciparum 3D7 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith. | F | 4.39 | pIC50 | 41063 | nM | IC50 | Open Source Malaria Deposition 1. http://malaria.ourexperiment.org |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as reduction in parasitemia after 48 hrs by fluorescence assay | F | 4.52 | pIC50 | 30400 | nM | IC50 | J Nat Prod (2014) 77: 1847-1852 [PMID:25076059] |
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 assessed as intraerythrocytic growth inhibition | F | 4.62 | pIC50 | 24000 | nM | IC50 | RSC Med Chem (2023) 14: 715-733 [PMID:37122550] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 30 hrs followed by addition of [3H]-hypoxanthine and measured after 18 hrs by liquid scintillation counting method | F | 4.68 | pIC50 | 21000 | nM | IC50 | Eur J Med Chem (2020) 193: 112215-112215 [PMID:32179331] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 assessed as intraerythrocytic growth inhibition | F | 4.77 | pIC50 | 17000 | nM | IC50 | RSC Med Chem (2023) 14: 715-733 [PMID:37122550] |
| ChEMBL | Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 infected erythrocytes by LDH assay | F | 4.8 | pIC50 | 15900 | nM | IC50 | Bioorg Med Chem (2009) 17: 741-751 [PMID:19084416] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum male gametocytes assessed as parasitic growth inhibition | F | 4.9 | pIC50 | 12700 | nM | IC50 | RSC Med Chem (2023) 14: 1227-1253 [PMID:37484560] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage chloroquine resistant Plasmodium falciparum dD2 assessed as parasitic growth inhibition measured after 3 days by HRP2-ELISA assay | F | 4.92 | pIC50 | 12000 | nM | IC50 | J Nat Prod (2023) 86: 1392-1401 [PMID:37257055] |
| ChEMBL | Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected in erythrocytes by LDH assay | F | 5 | pIC50 | 9900 | nM | IC50 | Bioorg Med Chem (2009) 17: 741-751 [PMID:19084416] |
| ChEMBL | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum | F | 5.47 | pIC50 | <3400 | nM | IC50 | J Med Chem (1987) 30: 1505-1509 [PMID:3302259] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum | F | 5.47 | pIC50 | <3400 | nM | IC50 | J Med Chem (1987) 30: 1505-1509 [PMID:3302259] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum D6 Sierra Leone relative to artemisinin | F | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1993) 36: 2552-2557 [PMID:8355254] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum female gametocytes assessed as parasitic growth inhibition | F | 6.52 | pIC50 | 300 | nM | IC50 | RSC Med Chem (2023) 14: 1227-1253 [PMID:37484560] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2019) 166: 206-223 [PMID:30711831] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) macrophage by reporter dye assay | F | 6.7 | pIC50 | 200 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3796-3802 [PMID:17698622] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis | F | 6.8 | pIC50 | 159 | nM | IC50 | Bioorg Med Chem (2015) 23: 1817-1827 [PMID:25766631] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 after 72 hrs by LDH assay | F | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2084-2087 [PMID:26965857] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum male gametocytes assessed as parasitic growth inhibition by exflagellation assay | F | 6.92 | pIC50 | 120 | nM | IC50 | RSC Med Chem (2023) 14: 1227-1253 [PMID:37484560] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as parasite growth inhibition incubated for 48 hrs by LDH assay | F | 7.03 | pIC50 | 94 | nM | IC50 | RSC Med Chem (2023) 14: 122-134 [PMID:36760749] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay | F | 7.03 | pIC50 | 94 | nM | IC50 | Eur J Med Chem (2018) 143: 866-880 [PMID:29223887] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay | F | 7.03 | pIC50 | 94 | nM | IC50 | Eur J Med Chem (2018) 143: 866-880 [PMID:29223887] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition incubated for 48 hrs by LDH assay | F | 7.03 | pIC50 | 94 | nM | IC50 | RSC Med Chem (2023) 14: 122-134 [PMID:36760749] |
| ChEMBL | Antiplamodial activity against chloroquine-resistant bloodstream forms of Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as growth inhibition after 48 hrs by spectrophotometry | F | 7.04 | pIC50 | 91 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 5435-5438 [PMID:25454267] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum D6 after 72 hrs by LDH activity assay | F | 7.05 | pIC50 | <90 | nM | IC50 | Medchemcomm (2013) 4: 1042-1048 |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D6 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis | F | 7.05 | pIC50 | <90 | nM | IC50 | Eur J Med Chem (2015) 98: 160-169 [PMID:26005918] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum W2 after 72 hrs by LDH activity assay | F | 7.05 | pIC50 | <90 | nM | IC50 | Medchemcomm (2013) 4: 1042-1048 |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis | F | 7.05 | pIC50 | <90 | nM | IC50 | Eur J Med Chem (2015) 98: 160-169 [PMID:26005918] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 | F | 7.1 | pIC50 | 80 | nM | IC50 | Eur J Med Chem (2019) 180: 562-612 [PMID:31344615] |
| ChEMBL | Antiplasmodial activity against IEF stage of Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method | F | 7.1 | pIC50 | 80 | nM | IC50 | J Nat Prod (2018) 81: 2682-2691 [PMID:30565934] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible blood forms of Plasmodium falciparum 3D7 infected in human erythrocytes measured after 48 hrs by SYBR green1 staining based fluorescence assay | F | 7.13 | pIC50 | 74 | nM | IC50 | Bioorg Med Chem (2018) 26: 3837-3844 [PMID:29983285] |
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum D6 after 72 hrs by LDH assay | F | 7.15 | pIC50 | 71 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2084-2087 [PMID:26965857] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum isolate 208432 infected in human erythrocytes after 48 hrs by flow-cytometry | F | 7.17 | pIC50 | 68.3 | nM | IC50 | J Med Chem (2010) 53: 3552-3557 [PMID:20349996] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.21 | pIC50 | 62.3 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.25 | pIC50 | 55.8 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum FCR3 | F | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 75-77 [PMID:12467620] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum FcB1/Colombia | F | 7.26 | pIC50 | 55 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 | F | 7.26 | pIC50 | 55 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by pLDH assay | F | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816] |
| ChEMBL | Antiplasmodial activity against chloroquine resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes preincubated for 24 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation analysis | F | 7.26 | pIC50 | 55 | nM | IC50 | ACS Med Chem Lett (2020) 11: 921-927 [PMID:32435406] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.27 | pIC50 | 54 | nM | IC50 | J Med Chem (2019) 62: 3503-3512 [PMID:30856324] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.29 | pIC50 | 51.6 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.29 | pIC50 | 51.6 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by pLDH assay | F | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by pLDH assay | F | 7.31 | pIC50 | 49.4 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant blood stage Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I-based fluorescence assay | F | 7.31 | pIC50 | 49 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1261-1264 [PMID:24530004] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.32 | pIC50 | 47.6 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth | F | 7.33 | pIC50 | 47 | nM | IC50 | Bioorg Med Chem (2015) 23: 5120-5130 [PMID:25913864] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs | F | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem (2009) 17: 7775-7782 [PMID:19833520] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by pLDH assay | F | 7.34 | pIC50 | 45.5 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCK by [3H]hypoxanthine uptake | F | 7.35 | pIC50 | 45 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2453-2455 [PMID:19329310] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay | F | 7.35 | pIC50 | 45 | nM | IC50 | Eur J Med Chem (2017) 129: 175-185 [PMID:28222317] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.37 | pIC50 | 42.8 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.37 | pIC50 | 42.8 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 infected in RBCs by parasitic LDH release assay | F | 7.37 | pIC50 | 42.5 | nM | IC50 | Bioorg Med Chem (2009) 17: 7949-7957 [PMID:19879765] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs | F | 7.4 | pIC50 | 40 | nM | IC50 | J Nat Prod (2005) 68: 1297-1299 [PMID:16124784] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay | F | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1261-1264 [PMID:24530004] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.43 | pIC50 | 36.8 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis | F | 7.44 | pIC50 | 36.2 | nM | IC50 | J Med Chem (2014) 57: 4916-4923 [PMID:24824551] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay | F | 7.44 | pIC50 | 36.2 | nM | IC50 | Eur J Med Chem (2015) 100: 10-17 [PMID:26063305] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 in erythrocytes after 72 hrs by LDH activity | F | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1675-1677 [PMID:19231182] |
| ChEMBL | Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 by Malstat LDH activity | F | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem (2009) 17: 5632-5638 [PMID:19574054] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 in parasite LDH assay | F | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1446-1449 [PMID:18248990] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D10 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.46 | pIC50 | 34.3 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR Green-1 dye based fluorescence assay | F | 7.48 | pIC50 | 33 | nM | IC50 | ACS Med Chem Lett (2019) 10: 966-971 [PMID:31223456] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D6 infected in RBCs by parasitic LDH release assay | F | 7.48 | pIC50 | 32.9 | nM | IC50 | Bioorg Med Chem (2009) 17: 7949-7957 [PMID:19879765] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by YOYO-1 dye-based flow cytometry | F | 7.49 | pIC50 | 32.1 | nM | IC50 | Eur J Med Chem (2017) 138: 993-1001 [PMID:28756265] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antimalarial activity against synchronized ring stage CQ-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry | F | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (2019) 62: 5562-5578 [PMID:31062592] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 assessed as parasite growth inhibition | F | 7.52 | pIC50 | 30 | nM | IC50 | J Nat Prod (2024) 87: 994-1002 [PMID:38421618] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | F | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2019) 166: 206-223 [PMID:30711831] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 assessed as plasmodial LDH activity after 72 hrs | F | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2011) 46: 2816-2827 [PMID:21530018] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs | F | 7.52 | pIC50 | 30 | nM | IC50 | J Nat Prod (2005) 68: 1297-1299 [PMID:16124784] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition and measured after 72 hrs by ELISA | F | 7.52 | pIC50 | 30 | nM | IC50 | J Nat Prod (2022) 85: 1211-1217 [PMID:35512262] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH release assay | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 322-325 [PMID:19910192] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition | F | 7.52 | pIC50 | 30 | nM | IC50 | J Nat Prod (2024) 87: 994-1002 [PMID:38421618] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay | F | 7.54 | pIC50 | 29 | nM | IC50 | Medchemcomm (2015) 6: 357-362 |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs | F | 7.55 | pIC50 | 28 | nM | IC50 | Bioorg Med Chem (2009) 17: 7775-7782 [PMID:19833520] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 7.55 | pIC50 | 28 | nM | IC50 | Nat Chem Biol (2008) 4: 347-356 [PMID:18454143] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum FCR3 assessed as reduction in parasite growth incubated for 72 hr by LDH assay | F | 7.59 | pIC50 | 26 | nM | IC50 | J Nat Prod (2022) 85: 2641-2649 [PMID:36282784] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 | F | 7.59 | pIC50 | 25.5 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2882-2886 [PMID:21489789] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 | F | 7.6 | pIC50 | 25.4 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2882-2886 [PMID:21489789] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone M4 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.6 | pIC50 | 25.3 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.6 | pIC50 | 25.2 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH release assay | F | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 322-325 [PMID:19910192] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay | F | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2017) 126: 675-686 [PMID:27936446] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay | F | 7.6 | pIC50 | 25 | nM | IC50 | J Nat Prod (2017) 80: 3120-3127 [PMID:29182338] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as plasmodial LDH activity after 72 hrs | F | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2011) 46: 2816-2827 [PMID:21530018] |
| ChEMBL | Antimalarial activity against erythrocytic stage of Plasmodium falciparum 3D7 incubated for 50 hrs | F | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127037-127037 [PMID:32081449] |
| ChEMBL | Antiplasmodial activity against CQ-resistant Plasmodium falciparum 3D7 blood stage form after 48 hrs by FACSort cytometry | F | 7.63 | pIC50 | 23.5 | nM | IC50 | J Med Chem (2013) 56: 556-567 [PMID:23273038] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by Malstat reagent based LDH assay | F | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2017) 129: 175-185 [PMID:28222317] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 | F | 7.64 | pIC50 | 23 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.65 | pIC50 | 22.3 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.65 | pIC50 | 22.3 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 72 hr by LDH assay | F | 7.66 | pIC50 | 22 | nM | IC50 | J Nat Prod (2022) 85: 2641-2649 [PMID:36282784] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by fluorescence assay | F | 7.68 | pIC50 | 21 | nM | IC50 | J Nat Prod (2010) 73: 985-987 [PMID:20462236] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining method | F | 7.68 | pIC50 | 21 | nM | IC50 | J Nat Prod (2009) 72: 1541-1543 [PMID:19637893] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 72 hrs by DAPI staining | F | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2012) 55: 5851-5858 [PMID:22686608] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as growth inhibition after 72 hrs by DAPI staining | F | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2012) 55: 5851-5858 [PMID:22686608] |
| ChEMBL | Antimalarial activity against synchronized ring stage CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry | F | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2019) 62: 5562-5578 [PMID:31062592] |
| ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 | F | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 127037-127037 [PMID:32081449] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by fluorescence assay | F | 7.68 | pIC50 | 21 | nM | IC50 | J Nat Prod (2010) 73: 985-987 [PMID:20462236] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining method | F | 7.68 | pIC50 | 21 | nM | IC50 | J Nat Prod (2009) 72: 1541-1543 [PMID:19637893] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.68 | pIC50 | 20.9 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.68 | pIC50 | 20.7 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.68 | pIC50 | 20.7 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.69 | pIC50 | 20.6 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.69 | pIC50 | 20.5 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7A assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting | F | 7.7 | pIC50 | 20 | nM | IC50 | ACS Med Chem Lett (2012) 3: 373-377 [PMID:24900481] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 assessed as parasite growth inhibition and measured after 72 hrs by ELISA | F | 7.7 | pIC50 | 20 | nM | IC50 | J Nat Prod (2022) 85: 1211-1217 [PMID:35512262] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting | F | 7.7 | pIC50 | 20 | nM | IC50 | ACS Med Chem Lett (2012) 3: 373-377 [PMID:24900481] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC assessed as parasite LDH activity after 72 hrs | F | 7.7 | pIC50 | 20 | nM | IC50 | J Nat Prod (2012) 75: 883-889 [PMID:22530813] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2mef ring form by hoechst 33342-thiazole orange stain based flow cytometry assay | F | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay | F | 7.7 | pIC50 | 19.78 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 7G8 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation | F | 7.71 | pIC50 | 19.7 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay | F | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2017) 139: 22-47 [PMID:28800458] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC assessed as plasmodial LDH activity after 72 hrs | F | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 112-116 [PMID:23218718] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A+ erythrocytes after 24 hrs by [3H]-hypoxanthine incorporation assay | F | 7.72 | pIC50 | 19 | nM | IC50 | Eur J Med Chem (2017) 139: 22-47 [PMID:28800458] |
| ChEMBL | Antimalarial activity against wild-type Plasmodium falcipuram 3D7 assessed as growth inhibition | F | 7.72 | pIC50 | 19 | nM | IC50 | J Nat Prod (2022) 85: 63-69 [PMID:34949088] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 7.73 | pIC50 | 18.43 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitemia after 48 hrs by flow cytometry analysis | F | 7.74 | pIC50 | 18.1 | nM | IC50 | ACS Med Chem Lett (2012) 3: 1029-1033 [PMID:24936235] |
| ChEMBL | Antimalarial activity against artemisinin-sensitive Plasmodium falciparum F32-TEM by SYBR green dye based fluorescence assay | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2021) 39: 127884-127884 [PMID:33636304] |
| ChEMBL | Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay | F | 7.74 | pIC50 | 18 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 423-424 [PMID:11212126] |
| ChEMBL | Anti-malarial activity against Plasmodium falciparum Dd2 | F | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1539-1541 [PMID:12699750] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay | F | 7.75 | pIC50 | 17.96 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay | F | 7.76 | pIC50 | 17.34 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing wild type ATP4 after 72 hrs by SYBR green based fluorescence assay | F | 7.77 | pIC50 | 17.16 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC after 72 hrs by LDH release assay | F | 7.77 | pIC50 | 17.1 | nM | IC50 | Eur J Med Chem (2019) 162: 277-289 [PMID:30448417] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 Sierra Leone | F | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2003) 46: 4244-4258 [PMID:13678403] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum SB1-A6 harboring mutations conferring drug-resistance by SYBR-green based assay | F | 7.78 | pIC50 | 16.6 | nM | IC50 | J Med Chem (2014) 57: 6642-6652 [PMID:25007124] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum SB1 after 72 hrs by SYBR I method | F | 7.78 | pIC50 | 16.6 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes | F | 7.79 | pIC50 | 16.3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 265-272 [PMID:29326018] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay | F | 7.79 | pIC50 | 16.25 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC after 72 hrs by LDH release assay | F | 7.79 | pIC50 | 16.2 | nM | IC50 | Eur J Med Chem (2019) 162: 277-289 [PMID:30448417] |
| ChEMBL | Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay | F | 7.8 | pIC50 | 16 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and expressing parental ATP4 after 72 hrs by SYBR green based fluorescence assay | F | 7.81 | pIC50 | 15.36 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs | F | 7.82 | pIC50 | 15.14 | nM | IC50 | J Nat Prod (1999) 62: 59-66 [PMID:9917283] |
| ChEMBL | Growth inhibition after 6 hrs in chloroquine-resistant Plasmodium falciparum FcB1 | F | 7.82 | pIC50 | 15 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150] |
| ChEMBL | In vitro inhibition of Plasmodium falciparum in [3H]hypoxanthine incorporation assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1433-1436 [PMID:15006377] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in erythrocytes after 72 hrs by LDH activity | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1675-1677 [PMID:19231182] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum IndoChina W2 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay | F | 7.82 | pIC50 | 15 | nM | IC50 | ACS Med Chem Lett (2013) 4: 637-641 [PMID:24900723] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum assessed as [35S]Met/Cys incorporation by SYBR green based fluorescence assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antiplasmodial activity against synchronized ring stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Eur J Med Chem (2018) 155: 623-638 [PMID:29929118] |
| ChEMBL | Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum INDO infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Eur J Med Chem (2018) 155: 623-638 [PMID:29929118] |
| ChEMBL | Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 by Malstat LDH activity | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem (2009) 17: 5632-5638 [PMID:19574054] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 in parasite LDH assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1446-1449 [PMID:18248990] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green based fluorescence assay | F | 7.82 | pIC50 | 15 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as parasite growth inhibition after 48 hrs by YOYO1 probe-based flow cytometric method | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 1693-1697 [PMID:28318947] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs | F | 7.84 | pIC50 | 14.6 | nM | IC50 | J Nat Prod (1999) 62: 59-66 [PMID:9917283] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum HB3 by [3H]hypoxanthine uptake | F | 7.84 | pIC50 | 14.5 | nM | IC50 | J Med Chem (2004) 47: 1290-1298 [PMID:14971909] |
| ChEMBL | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina | F | 7.84 | pIC50 | 14.5 | nM | IC50 | J Med Chem (2003) 46: 4244-4258 [PMID:13678403] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6 | F | 7.84 | pIC50 | 14.5 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS analysis | F | 7.85 | pIC50 | 14.1 | nM | IC50 | J Med Chem (2014) 57: 4916-4923 [PMID:24824551] |
| ChEMBL | In vitro antimalarial activity against ring stage of chloroquine-resistant Plasmodium falciparum W2 cultured in medium containing 10% human serum assessed as inhibition of parasite growth after 48 hrs by YOYO-1 dye based flow cytometry | F | 7.85 | pIC50 | 14 | nM | IC50 | Eur J Med Chem (2013) 62: 590-596 [PMID:23434528] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC assessed as decrease in parasite viability after 72 hrs by LDH assay | F | 7.85 | pIC50 | 14 | nM | IC50 | Eur J Med Chem (2017) 126: 675-686 [PMID:27936446] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 | F | 7.85 | pIC50 | 14 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry | F | 7.85 | pIC50 | 14 | nM | IC50 | Eur J Med Chem (2014) 84: 425-432 [PMID:25038484] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by lactate dehydrogenase assay | F | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem (2014) 22: 4572-4580 [PMID:25115700] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs | F | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2011) 54: 5116-5130 [PMID:21644570] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by malaria SYBR Green I-based fluorescence assay | F | 7.87 | pIC50 | 13.5 | nM | IC50 | J Nat Prod (2010) 73: 885-889 [PMID:20429578] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 | F | 7.87 | pIC50 | 13.5 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354] |
| ChEMBL | Antiplasmodial activity against artemisinin-resistant Plasmodium falciparum Cam 3.1 R539 assessed as growth inhibition by SYBER green 1 dye based fluorescence assay | F | 7.87 | pIC50 | 13.48 | nM | IC50 | Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874] |
| ChEMBL | Antimalarial activity against CQ, MFQ-resistant Plasmodium falciparum TM91C235 clone Southeast asian isolate assessed as inhibition of parasite proliferation by MSF assay | F | 7.87 | pIC50 | 13.4 | nM | IC50 | J Med Chem (2014) 57: 4134-4153 [PMID:24742203] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 | F | 7.88 | pIC50 | 13.3 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum TM91C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2006) 49: 3790-3799 [PMID:16789736] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum TM91C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2007) 50: 5118-5127 [PMID:17887664] |
| ChEMBL | Antimalarial activity against multi drug resistant Plasmodium falciparum TM91C235 after 72 hrs by MSF assay | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2013) 56: 5860-5871 [PMID:23815186] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2008) 51: 6216-6219 [PMID:18774792] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum TM91C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2008) 51: 2261-2266 [PMID:18330976] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2011) 54: 1157-1169 [PMID:21265542] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 | F | 7.88 | pIC50 | 13.04 | nM | IC50 | J Med Chem (2008) 51: 4388-4391 [PMID:18637666] |
| ChEMBL | Antimalarial activity against chloroquine /mefloquine/pyrimethamine-resistant Plasmodium falciparum C235 by malaria SYBR green 1-based fluorescence (MSF) assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841] |
| ChEMBL | Inhibitory concentration against Plasmodium falciparum D6 infected erythrocytes | F | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (1994) 37: 1486-1494 [PMID:8182707] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 by pLDH assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2006) 49: 7088-7094 [PMID:17125261] |
| ChEMBL | Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Science (2010) 329: 1175-1180 [PMID:20813948] |
| ChEMBL | Antiplasmodial activity against asexual blood stage chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition by image-based assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 2645-2647 [PMID:24813731] |
| ChEMBL | Antimalarial activity against mutidrug resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | Antiplasmodial activity against synchronized ring stage of chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2018) 155: 623-638 [PMID:29929118] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive ring-stage Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green1 dye-based assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Nat Prod (2020) 83: 1751-1765 [PMID:32468815] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 | F | 7.89 | pIC50 | 13 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as intraerythrocytic growth inhibition | F | 7.89 | pIC50 | 13 | nM | IC50 | RSC Med Chem (2023) 14: 715-733 [PMID:37122550] |
| ChEMBL | Antimalarial activity against MMV848 resistant Plasmodium falciparum 3D7r_MMV848 assessed as reduction in parasitemia measured after 72 hrs by SYBR Green I dye based fluorescence assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Nat Prod (2023) 86: 1476-1486 [PMID:37289832] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage chloroquine sensitive Plasmodium falciparum 3D7 assessed as parasitic growth inhibition measured after 3 days by HRP2-ELISA assay | F | 7.89 | pIC50 | 13 | nM | IC50 | J Nat Prod (2023) 86: 1392-1401 [PMID:37257055] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by [3H]hypoxanthine incorporation assay | F | 7.89 | pIC50 | 12.8 | nM | IC50 | J Med Chem (2010) 53: 633-640 [PMID:19957999] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 7.9 | pIC50 | 12.6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 6124-6130 [PMID:16978862] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by malaria SYBR Green I-based fluorescence assay | F | 7.9 | pIC50 | 12.5 | nM | IC50 | J Nat Prod (2010) 73: 885-889 [PMID:20429578] |
| ChEMBL | In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1 | F | 7.9 | pIC50 | 12.5 | nM | IC50 | J Med Chem (2002) 45: 1052-1063 [PMID:11855985] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 7.9 | pIC50 | 12.5 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 4 hrs | F | 7.9 | pIC50 | 12.5 | nM | IC50 | J Med Chem (2010) 53: 8202-8206 [PMID:20979352] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum F32 | F | 7.9 | pIC50 | 12.5 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354] |
| ChEMBL | Growth inhibition of Plasmodium falciparum Dd2 ring stage infected erythrocytes after 72 hrs by DAPI fluorimetry | F | 7.91 | pIC50 | 12.35 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | F | 7.91 | pIC50 | 12.3 | nM | IC50 | Bioorg Med Chem (2009) 17: 1325-1338 [PMID:19136263] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake | F | 7.91 | pIC50 | 12.3 | nM | IC50 | J Med Chem (2004) 47: 1290-1298 [PMID:14971909] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum FcM29 | F | 7.91 | pIC50 | 12.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum FcB1 | F | 7.91 | pIC50 | 12.2 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 1100-1106 [PMID:19015354] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 dye based assay | F | 7.92 | pIC50 | 12.1 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 40-42 [PMID:29162457] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Medchemcomm (2012) 3: 1505-1511 [PMID:23205265] |
| ChEMBL | Antiplasmodial activity against ring-stage chloroquine-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite viability after 72 hrs by SYBR Green I dye-based assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 3368-3371 [PMID:30219526] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A positive erythrocyte assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Medchemcomm (2015) 6: 357-362 |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 7.92 | pIC50 | 12 | nM | IC50 | Medchemcomm (2011) 2: 1201-1207 |
| ChEMBL | In vitro antimalarial activity against drug-resistant Plasmodium falciparum NF54 | F | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1999) 42: 1477-1480 [PMID:10212135] |
| ChEMBL | Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes | F | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1994) 37: 1486-1494 [PMID:8182707] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 synchronized ring stage parasites infected in erythrocytes assessed as reduction in parasitemia after 48 hrs by Giemsa staining | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs | F | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2011) 54: 5116-5130 [PMID:21644570] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2mef by hypoxanthine uptake assay | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake | F | 7.95 | pIC50 | 11.23 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414] |
| ChEMBL | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 7.95 | pIC50 | 11.15 | nM | IC50 | J Med Chem (2001) 44: 58-68 [PMID:11141088] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining | F | 7.96 | pIC50 | 11 | nM | IC50 | Medchemcomm (2012) 3: 1505-1511 [PMID:23205265] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2mef assessed as DNA positive erythrocytes by hoechst 33342-thiazole orange stain based flow cytometry assay | F | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as plasmodial LDH activity after 72 hrs | F | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 112-116 [PMID:23218718] |
| ChEMBL | Antimalarial activity against CQ/SDX/PYR/MQ/CYC resistant Plasmodium falciparum Dd2 assessed as reduction in parasitemia measured after 72 hrs by SYBR Green I dye based fluorescence assay | F | 7.96 | pIC50 | 11 | nM | IC50 | J Nat Prod (2023) 86: 1476-1486 [PMID:37289832] |
| ChEMBL | Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay | F | 7.97 | pIC50 | 10.78 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676] |
| ChEMBL | Growth inhibition of Plasmodium falciparum 3D7 ring stage in infected erythrocytes after 72 hrs in DAPI fluorimetry | F | 7.97 | pIC50 | 10.78 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry | F | 7.97 | pIC50 | 10.63 | nM | IC50 | Eur J Med Chem (2014) 71: 128-134 [PMID:24287561] |
| ChEMBL | Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone) | F | 7.98 | pIC50 | 10.53 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures by PicoGreen dye based assay | F | 7.98 | pIC50 | 10.4 | nM | IC50 | J Med Chem (2018) 61: 8847-8858 [PMID:30192536] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 harboring mutations conferring drug-resistance by SYBR-green based assay | F | 7.99 | pIC50 | 10.3 | nM | IC50 | J Med Chem (2014) 57: 6642-6652 [PMID:25007124] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR I method | F | 7.99 | pIC50 | 10.26 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Growth inhibition of Plasmodium falciparum as reduced [3H]hypoxanthine incorporation | F | 8 | pIC50 | 10.11 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum DD2 by [3H]hypoxanthine uptake | F | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 972-975 [PMID:19097788] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as parasite LDH activity after 72 hrs | F | 8 | pIC50 | 10 | nM | IC50 | J Nat Prod (2012) 75: 883-889 [PMID:22530813] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in red blood cells after 72 hrs by parasitic LDH assay | F | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2012) 3: 555-559 [PMID:24900509] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by parasitic LDH assay | F | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2012) 3: 555-559 [PMID:24900509] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1(CQR)Colombia incubated for 48 hrs by classical radioactive microdilution method | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability incubated for 48 hrs by APAD colorimetric test | F | 8 | pIC50 | 10 | nM | IC50 | J Nat Prod (2019) 82: 1361-1366 [PMID:30943031] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2(CQR)Indo-China incubated for 48 hrs by classical radioactive microdilution method | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1999) 42: 1477-1480 [PMID:10212135] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum D2 | F | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 1833-1839 [PMID:15027875] |
| ChEMBL | Antiplasmodial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay | F | 8 | pIC50 | 10 | nM | IC50 | J Nat Prod (2017) 80: 1750-1757 [PMID:28557449] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 schizonts infected in human erythrocytes assessed as inhibition of parasite invasion after 24 hrs by Diff-Quick staining based microscopic analysis | F | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 5007-5008 [PMID:27623546] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Palo Alto(CQR)Ouganda incubated for 48 hrs by classical radioactive microdilution method | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum PaloAlto | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum FcB1 Colombia | F | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum resistant W-2 | F | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2629-2631 [PMID:15863331] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 8 | pIC50 | 9.9 | nM | IC50 | J Med Chem (1999) 42: 300-304 [PMID:9925735] |
| ChEMBL | Antiplasmodial activity against artemisinin-tolerant Plasmodium falciparum F32-Tanzania after 1000 days | F | 8 | pIC50 | 9.9 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 1872-1877 [PMID:20160056] |
| ChEMBL | Antiplasmodial activity against artemisinin-tolerant Plasmodium falciparum F32-Tanzania | F | 8 | pIC50 | 9.9 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 1872-1877 [PMID:20160056] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 8 | pIC50 | 9.9 | nM | IC50 | J Med Chem (1998) 41: 952-964 [PMID:9526569] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 | F | 8.01 | pIC50 | 9.71 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 8.01 | pIC50 | 9.7 | nM | IC50 | J Med Chem (1999) 42: 4275-4280 [PMID:10543871] |
| ChEMBL | Growth inhibition of Plasmodium falciparum HB3 ring stage in infected erythrocytes after 72 hrs in DAPI fluorimetry | F | 8.01 | pIC50 | 9.7 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 | F | 8.01 | pIC50 | 9.67 | nM | IC50 | J Med Chem (2001) 44: 58-68 [PMID:11141088] |
| ChEMBL | Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay | F | 8.01 | pIC50 | 9.67 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake | F | 8.02 | pIC50 | 9.54 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake | F | 8.02 | pIC50 | 9.54 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 5804-5804 [PMID:18845438] |
| ChEMBL | Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2 blood stage form after 48 hrs by FACSort cytometry | F | 8.02 | pIC50 | 9.5 | nM | IC50 | J Med Chem (2013) 56: 556-567 [PMID:23273038] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF 54 | F | 8.03 | pIC50 | 9.3 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 903-908 [PMID:9871509] |
| ChEMBL | In vitro antimalarial activity in chloroquine-sensitive Plasmodium falciparum NF54 | F | 8.04 | pIC50 | 9.2 | nM | IC50 | J Med Chem (1998) 41: 940-951 [PMID:9526568] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by liquid scintillation and luminescence counting | F | 8.04 | pIC50 | 9.2 | nM | IC50 | Bioorg Med Chem (2010) 18: 2586-2597 [PMID:20227283] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 8.04 | pIC50 | 9.2 | nM | IC50 | J Med Chem (2008) 51: 2170-2177 [PMID:18341274] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 8.04 | pIC50 | 9.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1720-1724 [PMID:18243702] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2006) 49: 3790-3799 [PMID:16789736] |
| ChEMBL | Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR green1 dye based fluorescence assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Nat Prod (2018) 81: 475-483 [PMID:29048892] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive/mefloquine-resistant Plasmodium falciparum D6 by malaria SYBR green 1-based fluorescence (MSF) assay | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 incubated for 72 hours by DAPI-staining based confocal imaging analysis | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3326-3329 [PMID:27212070] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2008) 51: 6216-6219 [PMID:18774792] |
| ChEMBL | Antimalarial activity against chloroquine and pyrimethamine-sensitive Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs by MSF assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2013) 56: 5860-5871 [PMID:23815186] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF 54 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2003) 46: 1060-1065 [PMID:12620083] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2007) 50: 5118-5127 [PMID:17887664] |
| ChEMBL | Antimalarial activity against chloroquine-susceptible Plasmodium falciparum D6 after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum (Ghana) | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2629-2631 [PMID:15863331] |
| ChEMBL | Antimalarial activity against CQ, MFQ-susceptible Plasmodium falciparum D6 clone Sierra 1/UNC isolate assessed as inhibition of parasite proliferation by MSF assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2014) 57: 4134-4153 [PMID:24742203] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2008) 51: 2261-2266 [PMID:18330976] |
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum F32 | F | 8.05 | pIC50 | 9 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3263-3267 [PMID:24974345] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by pLDH assay | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2006) 49: 7088-7094 [PMID:17125261] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum SGE2 | F | 8.05 | pIC50 | 9 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491] |
| ChEMBL | Antimalarial activity against chloroquine,mefloquine-sensitive Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2008) 51: 4388-4391 [PMID:18637666] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by lactate dehydrogenase assay | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem (2014) 22: 4572-4580 [PMID:25115700] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH reporter assay | F | 8.05 | pIC50 | 9 | nM | IC50 | Bioorg Med Chem (2008) 16: 5254-5265 [PMID:18362073] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2011) 54: 1157-1169 [PMID:21265542] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum NF54 | F | 8.05 | pIC50 | 8.9 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2991-2995 [PMID:16527481] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 8.05 | pIC50 | 8.9 | nM | IC50 | Medchemcomm (2012) 3: 281-297 |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant blood-stage Plasmodium falciparum W2 after 48 hrs by flow cytometric analysis | F | 8.06 | pIC50 | 8.76 | nM | IC50 | Eur J Med Chem (2012) 54: 887-899 [PMID:22683112] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum African D6 | F | 8.07 | pIC50 | 8.6 | nM | IC50 | J Med Chem (2000) 43: 3274-3282 [PMID:10966746] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 ring stage parasite assessed as decrease in parasite viability after 72 hrs by SYBR green 1 dye based assay | F | 8.07 | pIC50 | 8.5 | nM | IC50 | J Nat Prod (2018) 81: 1260-1265 [PMID:29738243] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability incubated for 72 hrs by SYBR Green I dye based assay | F | 8.07 | pIC50 | 8.5 | nM | IC50 | J Nat Prod (2019) 82: 431-439 [PMID:30354100] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum D6 (Sierra Leone) | F | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (2000) 43: 1246-1249 [PMID:10737758] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum. | F | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (1998) 41: 2164-2167 [PMID:9622557] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | F | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (2000) 43: 2753-2758 [PMID:10893313] |
| ChEMBL | In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum African D6 | F | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (2002) 45: 3331-3336 [PMID:12139444] |
| ChEMBL | Antimicrobial activity against wild type Plasmodium falciparum HB3 infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay | F | 8.08 | pIC50 | 8.36 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 (Thailand) assessed as growth inhibition by [3H]hypoxanthine incorporation assay | F | 8.09 | pIC50 | 8.2 | nM | IC50 | J Med Chem (2010) 53: 633-640 [PMID:19957999] |
| ChEMBL | Antimalarial activity against chloroquine-resistant erythrocyte stage of Plasmodium falciparum W2 after 48 hrs | F | 8.09 | pIC50 | 8.2 | nM | IC50 | ACS Med Chem Lett (2014) 5: 108-112 [PMID:24900781] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2mef schizont form by hoechst 33342-thiazole orange stain based flow cytometry assay | F | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2006) 49: 1576-1584 [PMID:16509575] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCB infected in human A-positive type erythrocytes after 72 hrs by SRB assay | F | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2011) 54: 8207-8213 [PMID:22023506] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum FcR3 Gambia | F | 8.1 | pIC50 | 8 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum D6 | F | 8.1 | pIC50 | 8 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Mad20 | F | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FC27 | F | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against mefloquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH assay | F | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29 | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of malarial growth | F | 8.11 | pIC50 | 7.81 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as reduction in malarial growth cells | F | 8.11 | pIC50 | 7.81 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum NF54 assessed as reduction in malarial growth | F | 8.11 | pIC50 | 7.81 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hours by DAPI-staining based confocal imaging analysis | F | 8.11 | pIC50 | 7.75 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3326-3329 [PMID:27212070] |
| ChEMBL | Antimicrobial activity against leupeptin resistant-Plasmodium falciparum HB3-leuR1 mutant infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay | F | 8.11 | pIC50 | 7.71 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109] |
| ChEMBL | Antiplasmodial activity against atovaquone-resistant Plasmodium falciparum FCR3 after 48 hrs by FACS analysis | F | 8.11 | pIC50 | 7.7 | nM | IC50 | J Med Chem (2014) 57: 4916-4923 [PMID:24824551] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes | F | 8.14 | pIC50 | 7.31 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2976-2979 [PMID:22414614] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum W2 (Indochina) | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2000) 43: 1246-1249 [PMID:10737758] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by flow-cytometry | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2010) 53: 3552-3557 [PMID:20349996] |
| ChEMBL | In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2002) 45: 3331-3336 [PMID:12139444] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2000) 43: 2753-2758 [PMID:10893313] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (1996) 39: 4511-4514 [PMID:8893847] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2010) 53: 4555-4559 [PMID:20476788] |
| ChEMBL | Antimalarial activity in Plasmodium falciparum Indochina W2 | F | 8.14 | pIC50 | 7.3 | nM | IC50 | J Med Chem (2000) 43: 3274-3282 [PMID:10966746] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as reduction in parasite replication incubated for 62 hrs | F | 8.14 | pIC50 | 7.2 | nM | IC50 | J Nat Prod (2012) 75: 1206-1209 [PMID:22680914] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR-green based assay | F | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2014) 57: 6642-6652 [PMID:25007124] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 72 hrs by SYBR I method | F | 8.15 | pIC50 | 7.05 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29(CQR)Cameroon incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2mef trophozoite form by hoechst 33342-thiazole orange stain based flow cytometry assay | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5452-5457 [PMID:19666223] |
| ChEMBL | Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I assay | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem (2013) 21: 7591-7594 [PMID:24239390] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR Green 1-based fluorescence assay | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem (2014) 22: 269-276 [PMID:24326280] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 756-759 [PMID:24424135] |
| ChEMBL | Antimalarial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 by malaria SYBR green 1-based fluorescence (MSF) assay | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841] |
| ChEMBL | Antiplasmodial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum FcM29-Cameroon by [3H]hypoxanthine uptake | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6075-6078 [PMID:17904365] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR Green-based method | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 952-955 [PMID:25599834] |
| ChEMBL | Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 by SYBR green-based assay | F | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1100-1103 [PMID:25650255] |
| ChEMBL | Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green I-based fluorescence assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Nat Prod (2015) 78: 1330-1338 [PMID:26042470] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2016) 59: 264-281 [PMID:26640981] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green-based fluorescence assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Nat Prod (2016) 79: 1952-1961 [PMID:27447736] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I dye-based assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Nat Prod (2017) 80: 1639-1647 [PMID:28463001] |
| ChEMBL | Antiplasmodial activity against ring-stage of chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye-based flow cytometric method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2018) 143: 150-156 [PMID:29174811] |
| ChEMBL | Antiprotozoal activity against erythrocytic stage of Plasmodium falciparum K1 after 48 hrs by [3H]- hypoxanthine incorporation assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2019) 62: 1330-1347 [PMID:30615444] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6(CQS)Sierra Leone incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32(CQS)Tanzania incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcR3(CQR)Gambia incubated for 48 hrs by classical radioactive microdilution method | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum FcM29 Cameron | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 | F | 8.15 | pIC50 | 7 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum FcM29 assessed as inhibition of plasmodial growth | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2021) 64: 9786-9874 [PMID:34213340] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as inhibition of parasitic growth | F | 8.16 | pIC50 | 6.9 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum NF54 assessed as reduction in cell growth | F | 8.16 | pIC50 | 6.9 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | Bioorg Med Chem (2008) 16: 7039-7045 [PMID:18550377] |
| ChEMBL | Antimalarial activity against CQ-resistant, MFQ-susceptible Plasmodium falciparum W2 clone Indochina 1 isolate assessed as inhibition of parasite proliferation by MSF assay | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2014) 57: 4134-4153 [PMID:24742203] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2008) 51: 2261-2266 [PMID:18330976] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2006) 49: 3790-3799 [PMID:16789736] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2007) 50: 5118-5127 [PMID:17887664] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2011) 54: 1157-1169 [PMID:21265542] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by MSF assay | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2013) 56: 5860-5871 [PMID:23815186] |
| ChEMBL | Antimalarial activity against chloroquine-resistant, mefloquine-susceptible Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2008) 51: 6216-6219 [PMID:18774792] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2007) 50: 2468-2485 [PMID:17439202] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 8.17 | pIC50 | 6.7 | nM | IC50 | J Med Chem (2008) 51: 4388-4391 [PMID:18637666] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum INDO assessed as growth inhibition by SYBER green 1 dye based fluorescence assay | F | 8.18 | pIC50 | 6.6 | nM | IC50 | Eur J Med Chem (2021) 224: 113685-113685 [PMID:34303874] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of cell growth incubated for 72 hrs by SYBR Green I staining based fluorescence analysis | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as reduction in malarial growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of malarial growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of malarial growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D6 assessed as inhibition of parasitic growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 assessed as inhibition of parasitic growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 assessed as inhibition of parasitic growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 assessed as inhibition of cell growth | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2016) 59: 7360-7388 [PMID:27010926] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 8.18 | pIC50 | 6.6 | nM | IC50 | J Med Chem (2006) 49: 2731-2734 [PMID:16640333] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR I method | F | 8.19 | pIC50 | 6.52 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR Green 1 staining based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Nat Prod (2020) 83: 569-577 [PMID:31577436] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR green-based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1100-1103 [PMID:25650255] |
| ChEMBL | Antiplasmodial activity against ring stage Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR Green 1 staining based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Nat Prod (2020) 83: 1043-1050 [PMID:32227943] |
| ChEMBL | Antimalarial activity against CQ-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye based flow cytometry | F | 8.19 | pIC50 | 6.5 | nM | IC50 | Eur J Med Chem (2015) 95: 230-239 [PMID:25817773] |
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR Green-based method | F | 8.19 | pIC50 | 6.5 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 952-955 [PMID:25599834] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 harboring mutations conferring drug-resistance by SYBR-green based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Med Chem (2014) 57: 6642-6652 [PMID:25007124] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 by SYBR-green based assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Med Chem (2014) 57: 6642-6652 [PMID:25007124] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR I method | F | 8.19 | pIC50 | 6.47 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of trophozoites growth after 48 hrs | F | 8.19 | pIC50 | 6.46 | nM | IC50 | Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970] |
| ChEMBL | Inhibitory concentration against Plasmodium falciparum W2 Indochina | F | 8.19 | pIC50 | 6.41 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells assessed as reduction in parasite viability after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1390-1393 [PMID:25746816] |
| ChEMBL | Antiplasmodial activity against chloroquine/pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2016) 24: 3781-3789 [PMID:27344215] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2007) 15: 5543-5550 [PMID:17544672] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559] |
| ChEMBL | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2009) 17: 3595-3603 [PMID:19395265] |
| ChEMBL | Antiprotozoal activity against chloroquine-, pyrimethamine-resistant Plasmodium falciparum K1 | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5457-5461 [PMID:16889962] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 | F | 8.19 | pIC50 | 6.4 | nM | IC50 | J Med Chem (1996) 39: 4511-4514 [PMID:8893847] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 erythrocytic stages incubated for 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2019) 27: 2052-2065 [PMID:30962114] |
| ChEMBL | Antiprotozoal activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2013) 21: 4988-4996 [PMID:23880082] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by microplate assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Eur J Med Chem (2010) 45: 179-185 [PMID:19879671] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 infected in human blood by [3H]hypoxanthine incorporation assay | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2010) 18: 6796-6804 [PMID:20709557] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Bioorg Med Chem (2008) 16: 6371-6378 [PMID:18502136] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counter | F | 8.19 | pIC50 | 6.4 | nM | IC50 | Eur J Med Chem (2012) 47: 510-519 [PMID:22136906] |
| ChEMBL | Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 as LDH activity | F | 8.2 | pIC50 | 6.3 | nM | IC50 | Bioorg Med Chem (2008) 16: 6702-6706 [PMID:18595720] |
| ChEMBL | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes after 48 hrs | F | 8.2 | pIC50 | 6.25 | nM | IC50 | Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay | F | 8.21 | pIC50 | 6.2 | nM | IC50 | Bioorg Med Chem (2016) 24: 2544-2548 [PMID:27112454] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by flow-cytometry | F | 8.21 | pIC50 | 6.1 | nM | IC50 | J Med Chem (2010) 53: 3552-3557 [PMID:20349996] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32 | F | 8.22 | pIC50 | 6 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigeria | F | 8.22 | pIC50 | 6 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150] |
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum 3D7 assessed as reduction in schizont maturation incubated for 24 hrs by Giemsa staining based assay | F | 8.22 | pIC50 | 6 | nM | IC50 | RSC Med Chem (2020) 11: 184-211 [PMID:33479627] |
| ChEMBL | Antiprotozoal activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected erythrocytes by [3H]hypoxanthine uptake | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2009) 52: 2016-2035 [PMID:19267462] |
| ChEMBL | Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green1-based fluorescence assay | F | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem (2016) 24: 5418-5422 [PMID:27624525] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2008) 51: 6927-6944 [PMID:18841956] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs assessed as [3H]hypoxanthine incorporation by liquid scintillation counting | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2010) 53: 254-272 [PMID:19928900] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum DD2 expressing Saccharomyces cerevisiae DHOD by [3H]hypoxanthine uptake | F | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 972-975 [PMID:19097788] |
| ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as 3H-hypoxanthine incorporation after 48 hrs by liquid scintillation counting | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antiplasmodial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected human erythrocytes by [3H]hypoxanthine uptake | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2009) 52: 4657-4667 [PMID:19606902] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by YOYO-1 dye based flow cytometric analysis | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2017) 60: 5889-5908 [PMID:28635296] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2007) 50: 5807-5823 [PMID:17948982] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as reduction in parasitemia measured after 72 hrs by SYBR Green I dye based fluorescence assay | F | 8.22 | pIC50 | 6 | nM | IC50 | J Nat Prod (2023) 86: 1476-1486 [PMID:37289832] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 cultured in human erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs by YOYO-1 staining based flow cytometry | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2015) 58: 5344-5354 [PMID:26067904] |
| ChEMBL | Antimalarial activity against CQ/PYR/ATO resistant Plasmodium falciparum TM90C6B assessed as reduction in parasitemia measured after 72 hrs by SYBR Green I dye based fluorescence assay | F | 8.22 | pIC50 | 6 | nM | IC50 | J Nat Prod (2023) 86: 1476-1486 [PMID:37289832] |
| ChEMBL | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of ring-stage parasite growth after 48 hrs | F | 8.23 | pIC50 | 5.92 | nM | IC50 | Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970] |
| ChEMBL | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of schizonts growth after 48 hrs | F | 8.23 | pIC50 | 5.91 | nM | IC50 | Bioorg Med Chem (2011) 19: 6604-6607 [PMID:21696970] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 72 hrs by SYBR green 1 dye based fluorescence assay | F | 8.23 | pIC50 | 5.9 | nM | IC50 | Bioorg Med Chem (2017) 25: 4203-4211 [PMID:28648491] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum | F | 8.24 | pIC50 | 5.82 | nM | IC50 | J Med Chem (1995) 38: 2311-2316 [PMID:7608896] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.24 | pIC50 | 5.7 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 1291-1296 [PMID:18268087] |
| ChEMBL | Antiplasmodial activity against erythrocyte stage of Plasmodium falciparum W2 assessed as growth inhibition after 48 hrs by flow cytometry | F | 8.25 | pIC50 | 5.64 | nM | IC50 | Medchemcomm (2012) 3: 1170-1172 |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum in 20 mM FeCl3 | F | 8.27 | pIC50 | 5.41 | nM | IC50 | J Med Chem (1995) 38: 2311-2316 [PMID:7608896] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC | F | 8.27 | pIC50 | 5.4 | nM | IC50 | ACS Med Chem Lett (2013) 4: 1037-1041 [PMID:24900603] |
| ChEMBL | Antiplasmodial activity against atovaquone-resistant Plasmodium falciparum FCR3 | F | 8.27 | pIC50 | 5.38 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 | F | 8.27 | pIC50 | 5.32 | nM | IC50 | Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911] |
| ChEMBL | Antimalarial activity against mid-ring stage of Plasmodium falciparum Fab9 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 8.28 | pIC50 | 5.2 | nM | IC50 | Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitaemia after 48 hrs by FACS | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2010) 53: 7864-7868 [PMID:20945914] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 18 hrs by SYBR Green-1 staining-based fluorescence assay | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2013) 56: 6190-6199 [PMID:23819803] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 401-405 [PMID:19091562] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake | F | 8.3 | pIC50 | 5 | nM | IC50 | J Nat Prod (2002) 65: 1381-1386 [PMID:12398531] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum NF54 | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 | F | 8.3 | pIC50 | 5 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150] |
| ChEMBL | Mean of EC50 values for FM3A cells/ mean of EC50 values for Plasmodium falciparum | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1997) 40: 633-638 [PMID:9057849] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition incubated for 48 hrs by flow cytometry based analysis | F | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2023) 256: 115458-115458 [PMID:37163950] |
| ChEMBL | Inhibitory concentration against Plasmodium falciparum K1 infected erythrocytes | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1994) 37: 1486-1494 [PMID:8182707] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA assay | F | 8.32 | pIC50 | 4.74 | nM | IC50 | Eur J Med Chem (2022) 244: 114774-114774 [PMID:36306538] |
| ChEMBL | In vivo antimalarial activity against Plasmodium falciparum D6 | F | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (1992) 35: 3023-3027 [PMID:1501229] |
| ChEMBL | Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation | F | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2008) 51: 1260-1277 [PMID:18260613] |
| ChEMBL | Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 as LDH activity | F | 8.35 | pIC50 | 4.5 | nM | IC50 | Bioorg Med Chem (2008) 16: 6702-6706 [PMID:18595720] |
| ChEMBL | Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry | F | 8.36 | pIC50 | 4.37 | nM | IC50 | Eur J Med Chem (2014) 84: 566-573 [PMID:25062007] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 | F | 8.37 | pIC50 | 4.3 | nM | IC50 | Medchemcomm (2014) 5: 927-931 |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum | F | 8.37 | pIC50 | 4.3 | nM | IC50 | J Nat Prod (2007) 70: 1565-1569 [PMID:17922552] |
| ChEMBL | Antimalarial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.37 | pIC50 | 4.3 | nM | IC50 | Bioorg Med Chem (2014) 22: 2629-2642 [PMID:24721829] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 72 hrs by [3H]hypoxanthine incorporation assay | F | 8.37 | pIC50 | 4.3 | nM | IC50 | J Med Chem (2013) 56: 1431-1442 [PMID:23360309] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S | F | 8.37 | pIC50 | 4.24 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3229-3232 [PMID:19435664] |
| ChEMBL | Antimalarial activity against mid-ring stage of multidrug-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.39 | pIC50 | 4.1 | nM | IC50 | Eur J Med Chem (2013) 67: 310-324 [PMID:23871911] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in type B+ human erythrocytes assessed as inhibition of parasitemia after 48 hrs by Giemsa staining | F | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2009) 44: 3388-3393 [PMID:19269069] |
| ChEMBL | In vitro inhibition against Plasmodium falciparum; range 0.004-0.02 uM | F | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (1988) 31: 1269-1277 [PMID:3290484] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green 1 assay | F | 8.4 | pIC50 | 4 | nM | IC50 | J Nat Prod (2017) 80: 96-107 [PMID:27997206] |
| ChEMBL | Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2013) 56: 5473-5494 [PMID:23795673] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis | F | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 3263-3267 [PMID:24974345] |
| ChEMBL | Antimalarial activity against ring-stage chloroquine-susceptible Plasmodium falciparum 3D7 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis | F | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2019) 163: 404-412 [PMID:30530192] |
| ChEMBL | Antiplasmodial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells after 48 hrs by lactate dehydrogenase assay | F | 8.4 | pIC50 | 4 | nM | IC50 | J Nat Prod (2017) 80: 1750-1757 [PMID:28557449] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 erythrocytic stage assessed as reduction in parasitic LDH activity measured after 48 hrs by colorimetric method | F | 8.4 | pIC50 | 4 | nM | IC50 | J Nat Prod (2017) 80: 1404-1410 [PMID:28368118] |
| ChEMBL | Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis | F | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2014) 22: 559-576 [PMID:24268543] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum K1 | F | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (1999) 42: 5487-5493 [PMID:10639291] |
| ChEMBL | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 strain | F | 8.47 | pIC50 | 3.4 | nM | IC50 | Eur J Med Chem (2021) 210: 112969-112969 [PMID:33148495] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage of multidrug-resistant Plasmodium falciparum Thailand K1 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay | F | 8.49 | pIC50 | 3.2 | nM | IC50 | ACS Med Chem Lett (2013) 4: 637-641 [PMID:24900723] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 | F | 8.52 | pIC50 | 3.04 | nM | IC50 | J Med Chem (1999) 42: 5487-5493 [PMID:10639291] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 | F | 8.52 | pIC50 | 3.04 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 | F | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2011) 54: 4581-4589 [PMID:21644541] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.55 | pIC50 | 2.8 | nM | IC50 | Medchemcomm (2012) 3: 281-297 |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.55 | pIC50 | 2.8 | nM | IC50 | Medchemcomm (2014) 5: 927-931 |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 assessed as inhibition of parasite growth | F | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2021) 64: 9786-9874 [PMID:34213340] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum infected in human O+ erythrocytes after 48 hrs by HRP2-ELISA method | F | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem (2010) 18: 5626-5633 [PMID:20621497] |
| ChEMBL | Antimalarial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem (2014) 22: 2629-2642 [PMID:24721829] |
| ChEMBL | In vitro inhibition of Plasmodium falciparum K1 (0.0008 ug/mL) | F | 8.55 | pIC50 | 2.8 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 595-597 [PMID:15664819] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine incorporation assay | F | 8.55 | pIC50 | 2.8 | nM | IC50 | J Med Chem (2013) 56: 1431-1442 [PMID:23360309] |
| ChEMBL | Antimalarial activity against ring-stage multidrug-resistant Plasmodium falciparum Dd2 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis | F | 8.6 | pIC50 | 2.5 | nM | IC50 | Eur J Med Chem (2019) 163: 404-412 [PMID:30530192] |
| ChEMBL | In vivo antimalarial activity against Plasmodium falciparum W-2 | F | 8.66 | pIC50 | 2.2 | nM | IC50 | J Med Chem (1992) 35: 3023-3027 [PMID:1501229] |
| ChEMBL | Antimalarial activity against mid-ring stage of Plasmodium falciparum GB4 infected in human O-positive erythrocytes after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 8.66 | pIC50 | 2.2 | nM | IC50 | Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Tm90-C2B infected in human Erythrocyte measured after 72 hrs by SYBR green fluorescence dye based microplate reader analysis | F | 8.68 | pIC50 | 2.1 | nM | IC50 | Eur J Med Chem (2018) 146: 1-14 [PMID:29360043] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake | F | 8.7 | pIC50 | 2 | nM | IC50 | J Nat Prod (2002) 65: 1381-1386 [PMID:12398531] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 harboring CRT mutant | F | 8.74 | pIC50 | 1.84 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 harboring DHODH mutant | F | 8.74 | pIC50 | 1.81 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 | F | 8.82 | pIC50 | 1.51 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antimalarial activity against chloroquine sensitive Plasmodium falciparum FCR-3 | F | 8.85 | pIC50 | 1.4 | nM | IC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 harboring mutations conferring drug-resistance by SYBR-green based assay | F | 8.89 | pIC50 | 1.3 | nM | IC50 | J Med Chem (2014) 57: 6642-6652 [PMID:25007124] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR I method | F | 8.89 | pIC50 | 1.3 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 harboring HSP90 mutant | F | 8.89 | pIC50 | 1.29 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 harboring CYTb-Qi mutant | F | 8.9 | pIC50 | 1.26 | nM | IC50 | J Med Chem (2014) 57: 5702-5713 [PMID:24914738] |
| ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS | F | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS | F | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH reporter assay | F | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem (2008) 16: 5254-5265 [PMID:18362073] |
| ChEMBL | Antiplasmodium activity against chloroquine-resistant intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green I staining-based assay | F | 9.09 | pIC50 | 0.82 | nM | IC50 | J Nat Prod (2015) 78: 431-440 [PMID:25650896] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D6 infected in human Erythrocyte measured after 72 hrs by SYBR green fluorescence dye based microplate reader analysis | F | 9.09 | pIC50 | 0.81 | nM | IC50 | Eur J Med Chem (2018) 146: 1-14 [PMID:29360043] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human Erythrocyte measured after 72 hrs by SYBR green fluorescence dye based microplate reader analysis | F | 9.22 | pIC50 | 0.6 | nM | IC50 | Eur J Med Chem (2018) 146: 1-14 [PMID:29360043] |
| ChEMBL | Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 7G8 in human erythrocytes by DAPI stain | F | 7.32 | pEC50 | 48 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067] |
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | F | 7.37 | pEC50 | 43 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as parasite growth inhibition incubated for 48 hrs by 3H-hypoxanthine incorporation assay | F | 7.52 | pEC50 | 30 | nM | EC50 | J Med Chem (2021) 64: 2739-2761 [PMID:33620219] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | F | 7.57 | pEC50 | 27 | nM | EC50 | Eur J Med Chem (2021) 220: 113454-113454 [PMID:33901900] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 after 72 hr by LDH assay | F | 7.6 | pEC50 | 25 | nM | EC50 | Med Chem Res (2005) 14: 74-105 |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 72 hr by LDH assay | F | 7.64 | pEC50 | 23 | nM | EC50 | Med Chem Res (2005) 14: 74-105 |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum W2 after 48 hrs by YOYO-1 probe-based flow cytometry | F | 7.64 | pEC50 | 23 | nM | EC50 | J Med Chem (2017) 60: 6911-6923 [PMID:28763614] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 SierraLeone after 48 hr by parasite LDH assay | F | 7.7 | pEC50 | 20 | nM | EC50 | Med Chem Res (2005) 14: 332-346 |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 IndoChina after 48 hr by parasite LDH assay | F | 7.7 | pEC50 | 20 | nM | EC50 | Med Chem Res (2005) 14: 332-346 |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation pretreated for 24 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method | F | 7.7 | pEC50 | 20 | nM | EC50 | ACS Med Chem Lett (2019) 10: 137-141 [PMID:30655961] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 by automated image mining based cytological profiling assay | F | 7.74 | pEC50 | 18 | nM | EC50 | J Med Chem (2014) 57: 7425-7434 [PMID:25137549] |
| ChEMBL | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum 7G8 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | F | 7.74 | pEC50 | 18 | nM | EC50 | Eur J Med Chem (2021) 220: 113454-113454 [PMID:33901900] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasite growth incubated for 48 hrs by YOYO-1 dye based flow cytometric analysis | F | 7.76 | pEC50 | 17.3 | nM | EC50 | ACS Med Chem Lett (2023) 14: 493-498 [PMID:37077383] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 as LDH activity after 48 hrs | F | 7.77 | pEC50 | 17 | nM | EC50 | J Med Chem (2004) 47: 6609-6615 [PMID:15588096] |
| ChEMBL | Antimalarial activity against chloroquine, pyrimethamine and mefloquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | F | 7.82 | pEC50 | 15 | nM | EC50 | Eur J Med Chem (2021) 220: 113454-113454 [PMID:33901900] |
| ChEMBL | Antiplasmodial activity against NITD609-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.82 | pEC50 | 15 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| ChEMBL | Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 3 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 106/1 in human erythrocytes by DAPI stain | F | 7.89 | pEC50 | 13 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067] |
| ChEMBL | Antiplasmodial activity against asexual blood stage Plasmodium falciparum 3D7 infected in human RBC assessed as parasite growth inhibition incubated for 72 hrs by SYBR Green dye based fluorescence assay | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2021) 64: 2739-2761 [PMID:33620219] |
| ChEMBL | Antimalarial activity against blood stages of chloroquine-sensitive Plasmodium falciparum 3D7 | F | 7.92 | pEC50 | 12.1 | nM | EC50 | Eur J Med Chem (2019) 163: 804-829 [PMID:30579122] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs as LDH reporter activity | F | 7.92 | pEC50 | 12 | nM | EC50 | J Med Chem (2004) 47: 6609-6615 [PMID:15588096] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 by automated image mining based cytological profiling assay | F | 7.96 | pEC50 | 11 | nM | EC50 | J Med Chem (2014) 57: 7425-7434 [PMID:25137549] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and mefloquine-resistant asexual blood stage of Plasmodium falciparum Dd2 assessed as reduction in parasite growth after 72 hrs by SYBR green I staining based fluorescence assay | F | 7.96 | pEC50 | 11 | nM | EC50 | ACS Med Chem Lett (2022) 13: 371-376 [PMID:35300082] |
| ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | F | 7.99 | pEC50 | 10.26 | nM | EC50 | Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783] |
| ChEMBL | In vitro antimalarial activity for Plasmodium falciparum | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2001) 44: 2357-2361 [PMID:11428929] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2003) 46: 1957-1961 [PMID:12723958] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum FCR3 | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2003) 46: 4351-4359 [PMID:13678413] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2002) 45: 4732-4736 [PMID:12361400] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2002) 45: 1374-1378 [PMID:11882006] |
| ChEMBL | Antimalarial activity Plasmodium falciparum 3D7 | F | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4027-4031 [PMID:20610151] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay | F | 8 | pEC50 | <10 | nM | EC50 | Nat Chem Biol (2008) 4: 347-356 [PMID:18454143] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum NF54 | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2012) 55: 291-296 [PMID:22128829] |
| ChEMBL | Antiplasmodial activity against chloroquine resistant Plasmodium falciparum W2 erythrocytic ring stage after 48 hrs using hypoxanthine by flow cytometric analysis | F | 8 | pEC50 | 10 | nM | EC50 | Eur J Med Chem (2018) 149: 69-78 [PMID:29499488] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and mefloquine-sensitive asexual blood stage of Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green I staining based fluorescence assay | F | 8 | pEC50 | 10 | nM | EC50 | ACS Med Chem Lett (2022) 13: 371-376 [PMID:35300082] |
| ChEMBL | Antiplasmodium activity against Plasmodium falciparum W2 by flow cytometry | F | 8.03 | pEC50 | 9.3 | nM | EC50 | ACS Med Chem Lett (2015) 6: 1145-1149 [PMID:26617969] |
| ChEMBL | In vitro antimalarial activity for Plasmodium falciparum NF54 infected mice (Mus musculus) | F | 8.06 | pEC50 | 8.8 | nM | EC50 | J Med Chem (2004) 47: 1299-1301 [PMID:14971910] |
| ChEMBL | Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum FCB in human erythrocytes by DAPI stain | F | 8.1 | pEC50 | 8 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 asexual blood stage infected in human erythrocytes incubated for 72 hrs by LDH assay | F | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 | F | 8.11 | pEC50 | 7.8 | nM | EC50 | J Med Chem (1999) 42: 3163-3166 [PMID:10447961] |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum D6 | F | 8.11 | pEC50 | 7.8 | nM | EC50 | J Med Chem (1999) 42: 2604-2609 [PMID:10411480] |
| ChEMBL | Antimalarial activity in Plasmodium falciparum FCR3 | F | 8.11 | pEC50 | 7.8 | nM | EC50 | J Med Chem (2000) 43: 3274-3282 [PMID:10966746] |
| ChEMBL | Antimalarial activity against erythrocytic stage of chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (2013) 56: 2975-2990 [PMID:23517371] |
| ChEMBL | Antimalarial activity against chloroquine and mefloquine resistant Plasmodium falciparum W2mef infected in human erythrocytes incubated for 72 hrs by LDH assay | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity against multidrug resistant Plasmodium falciparum K1 | F | 8.27 | pEC50 | 5.4 | nM | EC50 | Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985] |
| ChEMBL | Antimalarial activity against multidrug resistant Plasmodium falciparum Dd2 | F | 8.27 | pEC50 | 5.4 | nM | EC50 | Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 8.27 | pEC50 | 5.4 | nM | EC50 | Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985] |
| ChEMBL | Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 6 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay | F | 8.3 | pEC50 | 5 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes by DAPI stain | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067] |
| ChEMBL | Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 in human erythrocytes by DAPI stain | F | 8.4 | pEC50 | 4 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 6521-6524 [PMID:18993067] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 | F | 8.44 | pEC50 | 3.6 | nM | EC50 | Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 by automated image mining based cytological profiling assay | F | 8.52 | pEC50 | 3 | nM | EC50 | J Med Chem (2014) 57: 7425-7434 [PMID:25137549] |
| ChEMBL | Antimalarial activity against plasmodium falciparum 3D7 assessed as bacterial growth inhibition | F | 8.62 | pEC50 | 2.4 | nM | EC50 | Eur J Med Chem (2018) 151: 628-685 [PMID:29656203] |
| ChEMBL | Antimalarial activity against synchronous culture of Plasmodium falciparum 3D7 ring stage parasite infected in human erythrocytes incubated for 24 hrs followed by compound wash out and measured after 24 hrs by NanoGlo-reagent based bioluminescence assay | F | 8.7 | pEC50 | 2 | nM | EC50 | J Med Chem (2017) 60: 1171-1188 [PMID:28080063] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 assessed as reduction in parasitic growth incubated for 48 hrs by Giemsa-staining counting based microscopic analysis | F | 9 | pEC50 | 1 | nM | EC50 | Eur J Med Chem (2023) 256: 115458-115458 [PMID:37163950] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite growth incubated for 48 hrs by Giemsa-staining counting based microscopic analysis | F | 9 | pEC50 | 1 | nM | EC50 | Eur J Med Chem (2023) 256: 115458-115458 [PMID:37163950] |
| ChEMBL | Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocytes transfected with GFP-LUC assessed as growth inhibition incubated for 72 hrs by mitotracker Red-CMXROS dye based fluorescence microscopic analysis | F | 9.1 | pEC50 | 0.8 | nM | EC50 | J Med Chem (2016) 59: 9672-9685 [PMID:27631715] |
| Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | OSM: Inhibition of Plasmodium falciparum K1 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith. | F | 9 | pIC50 | 1 | nM | IC50 | Open Source Malaria Deposition 1. http://malaria.ourexperiment.org |
| Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889] | ||||||||
| ChEMBL | Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis | F | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2015) 95: 16-28 [PMID:25791675] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
