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The GtoMPdb includes species information for antimalarial ligands and their target interactions.
Each individual Malaria Target Species page provides a detailed description of the species and a table displaying all interactions (contained in the database) associated with it.
✖Species ID: | 126 | |
Name: | Plasmodium knowlesi | |
Associated with: | 2 targets | |
2 ligands |
Description |
P. knowlesi (Pk) is one of five protozoan parasite species of the genus Plasmodium that cause malaria in humans. This species of the parasite was originally identified as causing simian malaria but it is becoming a significant cause of zoonotic malaria and is an emerging public health issue in Southeast Asia. Pk has a 24-hour asexual replication cycle in erythrocytes and can progress quickly to severe clinical disease with fatal cases reported. |
Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS et al.. (2017) Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. Int J Parasitol Drugs Drug Resist, 7 (1): 42-50. [PMID:28107750]
2. Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C et al.. (2020) Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle. Cell Host Microbe, 27 (4): 642-658.e12. [PMID:32109369]