ChEMBL ligand: CHEMBL203125 (Fosmidomycin)
1-deoxy-D-xylulose 5-phosphate reductoisomerase in Escherichia coli [ChEMBL: CHEMBL3421521] [UniProtKB: W8T2T2] 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Mycobacterium tuberculosis [ChEMBL: CHEMBL5630] [UniProtKB: P9WNS1] 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [ChEMBL: CHEMBL2010623] [UniProtKB: A0QVH7] There should be some charts here, you may need to enable JavaScript!
1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic in Arabidopsis thaliana [ChEMBL: CHEMBL2285354] [UniProtKB: Q9XFS9] There should be some charts here, you may need to enable JavaScript!
1-deoxyxylulose-5-phosphate reductoisomerase in Escherichia coli [ChEMBL: CHEMBL4091] [UniProtKB: P45568] 1-deoxyxylulose-5-phosphate reductoisomerase in Synechocystis sp. (strain PCC 6803 / Kazusa) [ChEMBL: CHEMBL4094] [UniProtKB: Q55663] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Plasmodium falciparum A2 [GtoPdb: 2980] Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Plasmodium falciparum Dd2 [GtoPdb: 2980] Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Plasmodium falciparum HB3 [GtoPdb: 2980] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
1-deoxy-D-xylulose 5-phosphate reductoisomerase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421521] [UniProtKB: W8T2T2]
ChEMBL	Inhibition of recombinant Escherichia coli Dxr expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells using DOXP as substrate assessed as NADPH oxidation preincubated for 5 mins with NADPH followed by substrate addition by spectrophotometric analysis	B	6.36	pIC50	438	nM	IC50	J Med Chem (2015) 58: 2988-3001 [PMID:25781377]
1-deoxy-D-xylulose 5-phosphate reductoisomerase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5630] [UniProtKB: P9WNS1]
ChEMBL	Binding affinity to Mycobacterium tuberculosis DXR assessed as dissociation constant by spectrofluorimetric analysis in presence of NADPH and MnCl2	B	7.4	pKd	40	nM	Kd	J Med Chem (2013) 56: 6190-6199 [PMID:23819803]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preincubated for 10 mins	B	6.85	pKi	140	nM	Ki	J Med Chem (2011) 54: 4721-4734 [PMID:21561155]
ChEMBL	Inhibition of Mycobacterium tuberculosis Dxr	B	6.36	pIC50	440	nM	IC50	Bioorg Med Chem Lett (2014) 24: 649-653 [PMID:24360562]
ChEMBL	Inhibition of Mycobacterium tuberculosis IspC by photometric assay	B	6.64	pIC50	230	nM	IC50	J Med Chem (2013) 56: 8151-8162 [PMID:24032981]
ChEMBL	Inhibition of Mycobacterium tuberculosis DXR assessed as NADPH-dependent conversion of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate by spectrophotometric method	B	7.1	pIC50	80	nM	IC50	J Biol Chem (2007) 282: 19905-19916 [PMID:17491006]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and Mn2+ as cofactor preincubated for 10 mins	B	7.1	pIC50	80	nM	IC50	J Med Chem (2011) 54: 4721-4734 [PMID:21561155]
ChEMBL	Inhibition of Mycobacterium tuberculosis DXR assessed as reduction of 1-deoxy-D-xylulose 5-phosphate into 2-C-methyl-D-erythritol-4-phosphate measured for every 5 secs upto 500 secs by spectrophotometry analysis	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5403-5407 [PMID:21824775]
ChEMBL	Inhibition of Mycobacterium tuberculosis DXR using DXP as substrate assessed as formation of MEP measured every 5 secs for 180 secs by spectrophotometric analysis	B	7.1	pIC50	80	nM	IC50	J Med Chem (2013) 56: 6190-6199 [PMID:23819803]
1-deoxy-D-xylulose 5-phosphate reductoisomerase in Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010623] [UniProtKB: A0QVH7]
ChEMBL	Inhibition of Mycobacterium smegmatis DSM 43756 ATCC 19420 N-terminal his-tagged DXR expressed in XL1-blue Escherichia coli using NADPH and DXP as substrate preincubated for 2 mins with substrate before compound addition	B	6.29	pIC50	510	nM	IC50	Eur J Med Chem (2012) 51: 277-285 [PMID:22405649]
ChEMBL	Inhibition of Mycobacterium smegmatis DXR	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2012) 51: 277-285 [PMID:22405649]
1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic in Arabidopsis thaliana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285354] [UniProtKB: Q9XFS9]
ChEMBL	Inhibition of Arabidopsis thaliana IspC expressed in Escherichia coli after 40 min by spectrophotometric analysis	B	7	pIC50	100	nM	IC50	Pest Manag Sci (2013) 69: 559-563 [PMID:23471898]
1-deoxyxylulose-5-phosphate reductoisomerase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4091] [UniProtKB: P45568]
ChEMBL	Inhibition of recombinant Escherichia coli DXR	B	7.32	pIC50	48	nM	IC50	J Med Chem (2006) 49: 2656-2660 [PMID:16610809]
ChEMBL	Inhibition of His-tagged Escherichia coli DXR pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem (2014) 22: 3713-3719 [PMID:24890653]
ChEMBL	Inhibition of Escherichia coli Dxr	B	7.49	pIC50	32	nM	IC50	J Med Chem (2014) 57: 9740-9763 [PMID:25210872]
ChEMBL	Inhibition of recombinant Escherichia coli DXR	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1888-1891 [PMID:16439126]
ChEMBL	Inhibition of Escherichia coli DXR	B	7.52	pIC50	30	nM	IC50	ACS Med Chem Lett (2011) 2: 165-170 [PMID:21379374]
ChEMBL	Inhibitory concentration against DOXP reductoisomerase	B	7.7	pIC50	19.95	nM	IC50	J Med Chem (2005) 48: 3547-3563 [PMID:15887963]
1-deoxyxylulose-5-phosphate reductoisomerase in Synechocystis sp. (strain PCC 6803 / Kazusa) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4094] [UniProtKB: Q55663]
ChEMBL	Binding affinity against Synechocystis strain PCC6803 DXP reductoisomerase	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5309-5312 [PMID:15454217]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum D10 incubated for 3 days by HRP2 detection based ELISA method	F	5.89	pIC50	1300	nM	IC50	J Med Chem (2015) 58: 2025-2035 [PMID:25633870]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 in infected human erythrocytes after 48 hrs	F	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem (2008) 16: 3361-3371 [PMID:18158249]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1888-1891 [PMID:16439126]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition	F	6	pIC50	1000	nM	IC50	J Med Chem (2013) 56: 376-380 [PMID:23215035]
ChEMBL	Antiplasmodial activity against blood stage forms of multidrug-resistant Plasmodium falciparum Dd2 incubated for 3 days by HRP2 detection based ELISA method	F	6.09	pIC50	810	nM	IC50	J Med Chem (2015) 58: 2025-2035 [PMID:25633870]
ChEMBL	Inhibition of Plasmodium falciparum Dd2	F	6.32	pIC50	480	nM	IC50	J Med Chem (2006) 49: 2656-2660 [PMID:16610809]
ChEMBL	Inhibition of Plasmodium falciparum 3D7	F	6.4	pIC50	400	nM	IC50	J Med Chem (2006) 49: 2656-2660 [PMID:16610809]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2	F	6.44	pIC50	360	nM	IC50	Bioorg Med Chem Lett (2006) 16: 1888-1891 [PMID:16439126]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability by [3H]-hypoxanthine incorporation assay	F	6.54	pIC50	290	nM	IC50	J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 3 days by SYBR green I assay	F	5.93	pEC50	1170	nM	EC50	ACS Med Chem Lett (2013) 4: 278-282 [PMID:23795240]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	5.96	pEC50	1100	nM	EC50	ACS Med Chem Lett (2011) 2: 165-170 [PMID:21379374]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 after 3 days by SYBR green I assay	F	6.36	pEC50	440	nM	EC50	ACS Med Chem Lett (2013) 4: 278-282 [PMID:23795240]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method	F	6.06	pIC50	880	nM	IC50	J Med Chem (2015) 58: 2025-2035 [PMID:25633870]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite replication	F	5.43	pIC50	3700	nM	IC50	J Med Chem (2011) 54: 6796-6802 [PMID:21866890]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 by micro dilution assay	F	5.76	pIC50	1730	nM	IC50	J Med Chem (2010) 53: 5342-5346 [PMID:20568776]
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Plasmodium falciparum A2 [GtoPdb: 2980]
GtoPdb	Parasite growth inhibition assay	-	6.43	pIC50	370	nM	IC50	Science (1999) 285: 1573-6 [PMID:10477522]
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Plasmodium falciparum Dd2 [GtoPdb: 2980]
GtoPdb	Parasite growth inhibition assay	-	6.54	pIC50	290	nM	IC50	Science (1999) 285: 1573-6 [PMID:10477522]
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase in Plasmodium falciparum HB3 [GtoPdb: 2980]
GtoPdb	Parasite growth inhibition assay	-	6.46	pIC50	350	nM	IC50	Science (1999) 285: 1573-6 [PMID:10477522]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]