DSM705 [Ligand Id: 11554] activity data from GtoPdb

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

  • dihydroorotate dehydrogenase (quinone) in Human [GtoPdb: 2604] [UniProtKB: Q02127]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 dihydroorotate dehydrogenase (quinone) Human
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium berghei [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 Plasmodium falciparum dihydroorotate dehydrogenase Plasmodium bergheiPlasmodium falciparumPlasmodium vivaxPlasmodium falciparum 3D7
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydroorotate dehydrogenase (quinone) in Human [GtoPdb: 2604] [UniProtKB: Q02127]
GtoPdb Steady-state kinetic analysis. - 4 pIC50 >100000 nM IC50 J Med Chem (2021) 64: 6085-6136 [PMID:33876936]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium berghei [GtoPdb: 2949]
GtoPdb Parasite liver stage assay - 7.89 pEC50 13 nM EC50 J Med Chem (2021) 64: 6085-6136 [PMID:33876936]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb Steady-state kinetic analysis. - 7.02 pIC50 95 nM IC50 J Med Chem (2021) 64: 6085-6136 [PMID:33876936]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
GtoPdb Steady-state kinetic analysis. - 7.28 pIC50 52 nM IC50 J Med Chem (2021) 64: 6085-6136 [PMID:33876936]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
GtoPdb Parasite growth inhibition assay - 7.92 pEC50 12 nM EC50 J Med Chem (2021) 64: 6085-6136 [PMID:33876936]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.