ChEMBL ligand: CHEMBL3545365 (Altiratinib, DCC-2701, DP-5164)
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] There should be some charts here, you may need to enable JavaScript!
neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288] There should be some charts here, you may need to enable JavaScript!
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL	Inhibition of MET (unknown origin)	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Inhibition of c-MET (unknown origin)	B	8.57	pIC50	2.7	nM	IC50	Eur J Med Chem (2018) 158: 814-831 [PMID:30248654]
ChEMBL	Inhibition of cMET (unknown origin)	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2019) 62: 1731-1760 [PMID:30188734]
GtoPdb	-	-	8.57	pIC50	2.7	nM	IC50	WO2016061231. Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression (2016)
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL	Inhibition of TrkA (unknown origin)	B	9.07	pIC50	0.85	nM	IC50	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Inhibition of TRKA (unknown origin)	B	9.07	pIC50	0.85	nM	IC50	J Med Chem (2019) 62: 1731-1760 [PMID:30188734]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL	Inhibition of TrkB (unknown origin)	B	8.34	pIC50	4.6	nM	IC50	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Inhibition of TRKB (unknown origin)	B	8.34	pIC50	4.6	nM	IC50	J Med Chem (2019) 62: 1731-1760 [PMID:30188734]
neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
ChEMBL	Inhibition of TRKC (unknown origin)	B	8.08	pIC50	8.3	nM	IC50	J Med Chem (2019) 62: 1731-1760 [PMID:30188734]
ChEMBL	Inhibition of TrkC (unknown origin)	B	9.08	pIC50	0.83	nM	IC50	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL	Inhibition of TIE-2 (unknown origin)	B	8.1	pIC50	8	nM	IC50	J Med Chem (2016) 59: 8712-8756 [PMID:27299736]
ChEMBL	Inhibition of TIE2 (unknown origin)	B	8.1	pIC50	8	nM	IC50	J Med Chem (2019) 62: 1731-1760 [PMID:30188734]
GtoPdb	-	-	8.62	pIC50	2.4	nM	IC50	WO2016061231. Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression (2016)
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of VEGFR2 (unknown origin)	B	8.04	pIC50	9.2	nM	IC50	Eur J Med Chem (2018) 158: 814-831 [PMID:30248654]
ChEMBL	Inhibition of VEGFR2 (unknown origin)	B	8.04	pIC50	9.2	nM	IC50	J Med Chem (2019) 62: 1731-1760 [PMID:30188734]
GtoPdb	-	-	8.04	pIC50	9.2	nM	IC50	WO2016061231. Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression (2016)

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]