ChEMBL ligand: CHEMBL218291 (BCX-1777, Forodesine, Immucillin h, Mundesine, NSC-717904)
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Purine nucleoside phosphorylase in Plasmodium falciparum [ChEMBL: CHEMBL5648] [UniProtKB: Q8T9Z7] purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491] Purine nucleoside phosphorylase in Bovine [ChEMBL: CHEMBL2935] [UniProtKB: P55859] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in [3H]ethanolamine incorporation incubated for 18 hrs followed by addition of [3H]ethanolamine and measured after 48 hrs by scintillation counting method	F	7.2	pIC50	63	nM	IC50	J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
Purine nucleoside phosphorylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5648] [UniProtKB: Q8T9Z7]
ChEMBL	Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formation	B	7.54	pKi	29	nM	Ki	J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL	Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometry	B	9.07	pKi	0.86	nM	Ki	Eur J Med Chem (2010) 45: 5140-5149 [PMID:20817362]
ChEMBL	Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491]
ChEMBL	Inhibition of human PNP	B	10.25	pKd	0.06	nM	Kd	Eur J Med Chem (2010) 45: 5140-5149 [PMID:20817362]
ChEMBL	Inhibition of human PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation	B	7.14	pKi	72	nM	Ki	J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL	Initial binding affinity to human PNP His257Gly mutant	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2008) 18: 5900-5903 [PMID:18778937]
ChEMBL	Initial binding affinity to wild type human PNP	B	8.48	pKi	3.3	nM	Ki	Bioorg Med Chem Lett (2008) 18: 5900-5903 [PMID:18778937]
ChEMBL	Inhibition of human purine nucleoside phosphorylase; Initial rate.	B	8.48	pKi	3.3	nM	Ki	J Med Chem (2003) 46: 3412-3423 [PMID:12852771]
ChEMBL	Binding affinity towards Human Purine Nucleoside Phosphorylase was reported	B	8.48	pKi	3.3	nM	Ki	J Med Chem (2003) 46: 5271-5276 [PMID:14613329]
ChEMBL	Inhibition of human PNP activity	B	8.74	pKi	1.8	nM	Ki	J Med Chem (2006) 49: 6037-6045 [PMID:17004717]
GtoPdb	-	-	10.14	pKi	0.07	nM	Ki	Biochemistry (1998) 37: 8615-21 [PMID:9628722]
ChEMBL	Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)	B	10.14	pKi	0.07	nM	Ki	J Med Chem (2003) 46: 155-160 [PMID:12502369]
ChEMBL	Equilibrium binding affinity to wild type human PNP	B	10.24	pKi	0.06	nM	Ki	Bioorg Med Chem Lett (2008) 18: 5900-5903 [PMID:18778937]
ChEMBL	Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)	B	10.25	pKi	0.06	nM	Ki	J Med Chem (2004) 47: 3275-3281 [PMID:15163207]
ChEMBL	Inhibition of human PNP by xanthine-oxidase coupled assay	B	10.25	pKi	0.06	nM	Ki	J Med Chem (2009) 52: 1126-1143 [PMID:19170524]
ChEMBL	Dissociation constant against Human Purine Nucleoside Phosphorylase was reported	B	10.25	pKi	0.06	nM	Ki	J Med Chem (2003) 46: 5271-5276 [PMID:14613329]
ChEMBL	Inhibition of human PNP using inosine as substrate by xanthine oxidase coupled assay	B	10.25	pKi	0.06	nM	Ki	Medchemcomm (2018) 9: 1983-1993 [PMID:30627387]
ChEMBL	Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibition	B	10.25	pKi	0.06	nM	Ki	J Med Chem (2003) 46: 3412-3423 [PMID:12852771]
ChEMBL	Inhibition of human purine nucleoside phosphorylase	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2627-2629 [PMID:19386496]
ChEMBL	Inhibition of human PNP activity	B	8.46	pIC50	3.5	nM	IC50	J Med Chem (2006) 49: 6037-6045 [PMID:17004717]
ChEMBL	Inhibition of human recombinant PNP	B	10.22	pIC50	0.06	nM	IC50	J Med Chem (2021) 64: 17627-17655 [PMID:34894691]
Purine nucleoside phosphorylase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2935] [UniProtKB: P55859]
ChEMBL	Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry	B	10.64	pKd	0.02	nM	Kd	Bioorg Med Chem (2012) 20: 6758-6769 [PMID:23040896]
ChEMBL	Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inorganic phosphate	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2010) 18: 2275-2284 [PMID:20189401]
ChEMBL	Inhibitory activity of compound against bovine purine nucleoside phosphorylase (PNP)	B	10.64	pKi	0.02	nM	Ki	J Med Chem (2003) 46: 155-160 [PMID:12502369]
ChEMBL	Inhibition of bovine spleen PNP using inosine as substrate by xanthine oxidase coupled assay	B	10.64	pKi	0.02	nM	Ki	Medchemcomm (2018) 9: 1983-1993 [PMID:30627387]
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
GtoPdb	-	-	9.22	pKi	0.6	nM	Ki	J Biol Chem (2002) 277: 3219-25 [PMID:11707439]
GtoPdb	Parasite growth inhibition assay	-	7.46	pIC50	35	nM	IC50	J Biol Chem (2002) 277: 3226-31 [PMID:11706018]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]