forodesine [Ligand Id: 8272] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL218291 (Forodesine, BCX-1777, Fodosine)
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
1 CHEMBL218291_lig_chart_1 Plasmodium falciparum Plasmodium falciparum
There should be some charts here, you may need to enable JavaScript!
  • Purine nucleoside phosphorylase in Plasmodium falciparum [ChEMBL: CHEMBL5648] [UniProtKB: Q8T9Z7]
  • purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491]
  • Purine nucleoside phosphorylase in Bovine [ChEMBL: CHEMBL2935] [UniProtKB: P55859]
  • 10.64
2 CHEMBL218291_lig_chart_2 Purine nucleoside phosphorylase Plasmodium falciparumHumanBovine
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
  • This target only has 1 pki data point
  • 9.22
3 CHEMBL218291_lig_chart_3 Plasmodium falciparum purine nucleoside phosphorylase Plasmodium falciparum
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in [3H]ethanolamine incorporation incubated for 18 hrs followed by addition of [3H]ethanolamine and measured after 48 hrs by scintillation counting method F 7.2 pIC50 63 nM IC50 J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
Purine nucleoside phosphorylase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5648] [UniProtKB: Q8T9Z7]
ChEMBL Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formation B 7.54 pKi 29 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometry B 9.07 pKi 0.86 nM Ki Eur. J. Med. Chem. (2010) 45: 5140-5149 [PMID:20817362]
ChEMBL Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation B 9.22 pKi 0.6 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491]
ChEMBL Inhibition of human PNP B 10.25 pKd 0.06 nM Kd Eur. J. Med. Chem. (2010) 45: 5140-5149 [PMID:20817362]
ChEMBL Inhibition of human PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation B 7.14 pKi 72 nM Ki J Med Chem (2019) 62: 8365-8391 [PMID:30964283]
ChEMBL Initial binding affinity to human PNP His257Gly mutant B 7.96 pKi 11 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 5900-5903 [PMID:18778937]
ChEMBL Initial binding affinity to wild type human PNP B 8.48 pKi 3.3 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 5900-5903 [PMID:18778937]
ChEMBL Inhibition of human purine nucleoside phosphorylase; Initial rate. B 8.48 pKi 3.3 nM Ki J. Med. Chem. (2003) 46: 3412-3423 [PMID:12852771]
ChEMBL Binding affinity towards Human Purine Nucleoside Phosphorylase was reported B 8.48 pKi 3.3 nM Ki J. Med. Chem. (2003) 46: 5271-5276 [PMID:14613329]
ChEMBL Inhibition of human PNP activity B 8.74 pKi 1.8 nM Ki J. Med. Chem. (2006) 49: 6037-6045 [PMID:17004717]
GtoPdb - - 10.14 pKi 0.07 nM Ki Biochemistry (1998) 37: 8615-21 [PMID:9628722]
ChEMBL Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP) B 10.14 pKi 0.07 nM Ki J. Med. Chem. (2003) 46: 155-160 [PMID:12502369]
ChEMBL Equilibrium binding affinity to wild type human PNP B 10.24 pKi 0.06 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 5900-5903 [PMID:18778937]
ChEMBL Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP) B 10.25 pKi 0.06 nM Ki J. Med. Chem. (2004) 47: 3275-3281 [PMID:15163207]
ChEMBL Inhibition of human PNP by xanthine-oxidase coupled assay B 10.25 pKi 0.06 nM Ki J. Med. Chem. (2009) 52: 1126-1143 [PMID:19170524]
ChEMBL Dissociation constant against Human Purine Nucleoside Phosphorylase was reported B 10.25 pKi 0.06 nM Ki J. Med. Chem. (2003) 46: 5271-5276 [PMID:14613329]
ChEMBL Inhibition of human PNP using inosine as substrate by xanthine oxidase coupled assay B 10.25 pKi 0.06 nM Ki MedChemComm (2018) 9: 1983-1993
ChEMBL Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibition B 10.25 pKi 0.06 nM Ki J. Med. Chem. (2003) 46: 3412-3423 [PMID:12852771]
ChEMBL Inhibition of human purine nucleoside phosphorylase B 7 pIC50 100 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2627-2629 [PMID:19386496]
ChEMBL Inhibition of human PNP activity B 8.46 pIC50 3.5 nM IC50 J. Med. Chem. (2006) 49: 6037-6045 [PMID:17004717]
Purine nucleoside phosphorylase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2935] [UniProtKB: P55859]
ChEMBL Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry B 10.64 pKd 0.02 nM Kd Bioorg. Med. Chem. (2012) 20: 6758-6769 [PMID:23040896]
ChEMBL Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inorganic phosphate B 7.39 pKi 41 nM Ki Bioorg. Med. Chem. (2010) 18: 2275-2284 [PMID:20189401]
ChEMBL Inhibitory activity of compound against bovine purine nucleoside phosphorylase (PNP) B 10.64 pKi 0.02 nM Ki J. Med. Chem. (2003) 46: 155-160 [PMID:12502369]
ChEMBL Inhibition of bovine spleen PNP using inosine as substrate by xanthine oxidase coupled assay B 10.64 pKi 0.02 nM Ki MedChemComm (2018) 9: 1983-1993
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
GtoPdb - - 9.22 pKi 0.6 nM Ki J Biol Chem (2002) 277: 3219-25 [PMID:11707439]
GtoPdb Parasite growth inhibition assay - 7.46 pIC50 35 nM IC50 J Biol Chem (2002) 277: 3226-31 [PMID:11706018]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]