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ChEMBL ligand: CHEMBL2334045 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | Antimalarial activity against GFP-transfected Plasmodium berghei ANKA in mouse blood assessed as inhibition of schizont maturation compound incubated for 16 hrs followed by 8 hrs of [3H]hypoxanthine incorporation | F | 6.3 | pIC50 | >500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 24 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax | F | 6.3 | pIC50 | >500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
ChEMBL | Antimalarial activity against Plasmodium falciparum incubated for 24 hrs | F | 6.3 | pIC50 | >500 | nM | IC50 | J Med Chem (2020) 63: 4445-4467 [PMID:31913032] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 50 % serum | F | 9.22 | pIC50 | <0.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax | F | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
ChEMBL | Antimalarial activity against Plasmodium falciparum incubated for 72 hrs | F | 9.22 | pIC50 | 0.6 | nM | IC50 | J Med Chem (2020) 63: 4445-4467 [PMID:31913032] |
Plasmodium falciparum plasmepsin X in Plasmodium falciparum NF54 [GtoPdb: 3071] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 6.3 | pIC50 | >500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352] |
GtoPdb | Parasite growth inhibition assay | - | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]