ChEMBL ligand: CHEMBL2334045
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against GFP-transfected Plasmodium berghei ANKA in mouse blood assessed as inhibition of schizont maturation compound incubated for 16 hrs followed by 8 hrs of [3H]hypoxanthine incorporation	F	6.3	pIC50	>500	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 24 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax	F	6.3	pIC50	>500	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 50 % serum	F	9.22	pIC50	<0.6	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax	F	9.22	pIC50	0.6	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]