compound 49c [PMID: 29074775] [Ligand Id: 10418] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2334045 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
| ChEMBL | Antimalarial activity against GFP-transfected Plasmodium berghei ANKA in mouse blood assessed as inhibition of schizont maturation compound incubated for 16 hrs followed by 8 hrs of [3H]hypoxanthine incorporation | F | 6.3 | pIC50 | >500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 24 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax | F | 6.3 | pIC50 | >500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum incubated for 24 hrs | F | 6.3 | pIC50 | >500 | nM | IC50 | J Med Chem (2020) 63: 4445-4467 [PMID:31913032] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 50 % serum | F | 9.22 | pIC50 | <0.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax | F | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum incubated for 72 hrs | F | 9.22 | pIC50 | 0.6 | nM | IC50 | J Med Chem (2020) 63: 4445-4467 [PMID:31913032] |
| Plasmodium falciparum plasmepsin X in Plasmodium falciparum NF54 [GtoPdb: 3071] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.3 | pIC50 | >500 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352] |
| GtoPdb | Parasite growth inhibition assay | - | 9.22 | pIC50 | 0.6 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
