compound 49c [PMID: 29074775] [Ligand Id: 10418] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2334045
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  • Plasmodium falciparum plasmepsin X in Plasmodium falciparum NF54 [GtoPdb: 3071]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antimalarial activity against GFP-transfected Plasmodium berghei ANKA in mouse blood assessed as inhibition of schizont maturation compound incubated for 16 hrs followed by 8 hrs of [3H]hypoxanthine incorporation F 6.3 pIC50 >500 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 24 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax F 6.3 pIC50 >500 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
ChEMBL Antimalarial activity against Plasmodium falciparum incubated for 24 hrs F 6.3 pIC50 >500 nM IC50 J Med Chem (2020) 63: 4445-4467 [PMID:31913032]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 50 % serum F 9.22 pIC50 <0.6 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax F 9.22 pIC50 0.6 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 658-662 [PMID:23260352]
ChEMBL Antimalarial activity against Plasmodium falciparum incubated for 72 hrs F 9.22 pIC50 0.6 nM IC50 J Med Chem (2020) 63: 4445-4467 [PMID:31913032]
Plasmodium falciparum plasmepsin X in Plasmodium falciparum NF54 [GtoPdb: 3071]
GtoPdb Parasite growth inhibition assay - 6.3 pIC50 >500 nM IC50 Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352]
GtoPdb Parasite growth inhibition assay - 9.22 pIC50 0.6 nM IC50 Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]