(+)-SJ733 [Ligand Id: 9723] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4207489 (Sj733, Sj-733, SJ733)
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  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum V1/S [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum Dd2 [GtoPdb: 2971]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring ATP4 S358S mutant F 5.07 pIC50 8563 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antiplasmodial activity against PfATP4 inhibitor SJ557733-resistant Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by Griffith assay based fluorescence analysis F 5.1 pIC50 >8000 nM IC50 Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708]
ChEMBL Antimalarial activity against synchronous ring stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 72 hrs by Griffith assay based fluorescence analysis F 7.23 pIC50 58.7 nM IC50 Eur J Med Chem (2021) 221: 113518-113518 [PMID:34058708]
ChEMBL Antimalarial activity against wild type Plasmodium falciparum Dd2 F 7.37 pIC50 43 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antimalarial activity against chloroquine sensitive/sulfadoxine resistant Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasite growth after 72 hrs by Sybr green dye based spectrophotometry F 7.44 pEC50 36 nM EC50 J Med Chem (2016) 59: 7950-7962 [PMID:27505686]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum V1/S [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 7.22 pEC50 60 nM EC50 Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 7.4 pEC50 40 nM EC50 Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9]
GtoPdb Parasite growth inhibition assay - 7.52 pEC50 30 nM EC50 Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum Dd2 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 7.7 pEC50 20 nM EC50 Proc Natl Acad Sci USA (2014) 111: E5455-62 [PMID:25453091]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]