Apta-1   Click here for help

GtoPdb Ligand ID: 13556

Immunopharmacology Ligand Antimalarial Ligand
Compound class: Nucleic acid
Comment: Apta-1 is a 90-mer RNA aptamer that is designed to bind to a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as a mechanism to disrupt infectivity [1]. It contains 2'-OH RNA purine nucleotides and 2'-fluoro pyrimidine nucleotides (marked as 'f' in the sequence provided here). Apta-1 is also reported to bind to the heparin-binding exosite II of thrombin, which drives significant inhibition of protease-activated receptor (PAR) signalling in platelets and antithrombotic sequelae.
Classification Click here for help
Compound class Nucleic acid
Compound subclass Aptamer
Target PfEMP1
Database Links Click here for help
GtoPdb PubChem SID 500839966