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Plasmodium vivax

Species ID:104
Name:Plasmodium vivax
Associated with:1 targets
1 ligands
Description
P. vivax (Pv) is one of five protozoan parasite species of the genus Plasmodium that cause malaria in humans. Pv is the second most common cause of malaria in humans, after P. falciparum, and is prevalent in Southeast Asia and Latin America. Pv has a dormant liver stage that can reactivate and lead to clinical symptoms.

Interactions

Interactions
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Target Ligand Sp. Action Affinity Parameter Reference
Plasmodium falciparum dihydroorotate dehydrogenase DSM421 Pv - 6.7 pEC50 1
pEC50 6.7 (EC50 1.8x10-7 M) [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Blood-stage: schizont maturation assay using P. vivax field isolates.
Plasmodium falciparum dihydroorotate dehydrogenase DSM421 Pv Inhibition 7.0 pIC50 1
pIC50 7.0 (IC50 9.4x10-8 M) [1]
Description: Steady-state kinetic analysis of recombinant enzyme inhibition.

References

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1. Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh K, Tomchick DR, Manjalanagara K, Rudra KR et al.. (2016) A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis, 2 (12): 945-957. [PMID:27641613]