amodiaquine [Ligand Id: 10018] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL682 (Amodiaquin, Amodiaquine, Amodiaquinum, GNF-Pf-5648, NSC-13453, SJ000110703, Sunoquine)
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  • Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354]
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA B 5.27 pIC50 5400 nM IC50 Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs B 5.4 pIC50 4000 nM IC50 Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
Hemozoin in Plasmodium falciparum (target type: MACROMOLECULE) [ChEMBL: CHEMBL613898]
ChEMBL Inhibition of beta-hematin B 4.68 pIC50 21000 nM IC50 J Med Chem (2016) 59: 6512-6530 [PMID:27299916]
ChEMBL Inhibition of beta-hematin formation assessed as reduction in hemozoin formation incubated for 5 hrs by NP40 detergent-based assay B 4.89 pIC50 13000 nM IC50 MedChemComm (2019) 10: 450-455 [PMID:31015908]
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354]
ChEMBL Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity in presence of 5-(Pyridin-3-yl)-1-methylindole-3-carboxylic Acid Methyl Ester by hybrid reporter gene assay B 4.09 pEC50 82000 nM EC50 J Med Chem (2021) 64: 15126-15140 [PMID:34633810]
ChEMBL Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity by hybrid reporter gene assay B 4.39 pEC50 41000 nM EC50 J Med Chem (2021) 64: 15126-15140 [PMID:34633810]
ChEMBL Agonist activity at Gal4-fused human Nurr1 LBD expressed in HEK293T cells co-expressing firefly luciferase assessed as luciferase activity incubated for 12 to 14 hrs by hybrid reporter gene assay B 4.44 pEC50 36000 nM EC50 J Med Chem (2021) 64: 2659-2668 [PMID:33629841]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 asexual forms incubated for 72 hrs by luminescence method F 4.75 pIC50 17900 nM IC50 Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 42 hrs by beta counting method F 8.22 pIC50 6 nM IC50 Eur J Med Chem (2017) 126: 72-83 [PMID:27744189]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes after 48 hrs by SYBR Green based fluorescence assay F 8.22 pIC50 6 nM IC50 Eur J Med Chem (2017) 126: 72-83 [PMID:27744189]
ChEMBL Antimalarial activity against chloroquine-resistant and mefloquine-sensitive Plasmodium falciparum W2 ring stage form infected in human erythrocytes by spectrophotometric analysis F 8.22 pIC50 6 nM IC50 Bioorg Med Chem (2019) 27: 1002-1008 [PMID:30737133]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.3 pIC50 5 nM IC50 Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay F 7.91 pEC50 12.3 nM EC50 Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as growth inhibition by SYBR Green-1 assay F 8.23 pEC50 5.85 nM EC50 Eur. J. Med. Chem. (2015) 102: 320-333 [PMID:26295174]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.1 pIC50 8 nM IC50 Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay F 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. (2015) 23: 5419-5432 [PMID:26264839]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]