MMV030084 [Ligand Id: 11201] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL200889 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Binding affinity at bRaf kinase in fluorescent ligand displacement assay | B | 8.32 | pKd | 4.8 | nM | Kd | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| ChEMBL | Inhibition bRaf kinase activity | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium berghei [GtoPdb: 3013] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 6.7 | pIC50 | 199 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum [GtoPdb: 3013] | ||||||||
| GtoPdb | Kinase inhibition assay using recombinant PfPKG | - | 9.4 | pIC50 | 0.4 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum NF54 [GtoPdb: 3013] | ||||||||
| GtoPdb | Parasite exflagellation assay | - | 6.85 | pIC50 | 141 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.96 | pIC50 | 109 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum Dd2 [GtoPdb: 3013] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.92 | pIC50 | 120 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
