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ChEMBL ligand: CHEMBL200889 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
ChEMBL | Binding affinity at bRaf kinase in fluorescent ligand displacement assay | B | 8.32 | pKd | 4.8 | nM | Kd | Bioorg. Med. Chem. Lett. (2006) 16: 378-381 [PMID:16260133] |
ChEMBL | Inhibition bRaf kinase activity | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg. Med. Chem. Lett. (2006) 16: 378-381 [PMID:16260133] |
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium berghei [GtoPdb: 3013] | ||||||||
GtoPdb | Parasite liver stage assay | - | 6.7 | pIC50 | 199 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum [GtoPdb: 3013] | ||||||||
GtoPdb | Kinase inhibition assay using recombinant PfPKG | - | 9.4 | pIC50 | 0.4 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum NF54 [GtoPdb: 3013] | ||||||||
GtoPdb | Parasite exflagellation assay | - | 6.85 | pIC50 | 141 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 6.96 | pIC50 | 109 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum Dd2 [GtoPdb: 3013] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 6.92 | pIC50 | 120 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]