MMV030084 [Ligand Id: 11201] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL200889 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Binding affinity at bRaf kinase in fluorescent ligand displacement assay | B | 8.32 | pKd | 4.8 | nM | Kd | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| ChEMBL | Inhibition bRaf kinase activity | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 378-381 [PMID:16260133] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium berghei [GtoPdb: 3013] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 6.7 | pIC50 | 199 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum [GtoPdb: 3013] | ||||||||
| GtoPdb | Kinase inhibition assay using recombinant PfPKG | - | 9.4 | pIC50 | 0.4 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum NF54 [GtoPdb: 3013] | ||||||||
| GtoPdb | Parasite exflagellation assay | - | 6.85 | pIC50 | 141 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.96 | pIC50 | 109 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
| Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum Dd2 [GtoPdb: 3013] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 6.92 | pIC50 | 120 | nM | IC50 | Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
