MMV030084 [Ligand Id: 11201] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL200889
  • B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
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  • Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium berghei [GtoPdb: 3013]
  • Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum [GtoPdb: 3013]
  • Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum NF54 [GtoPdb: 3013]
  • Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719]
  • Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum Dd2 [GtoPdb: 3013]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
ChEMBL Binding affinity at bRaf kinase in fluorescent ligand displacement assay B 8.32 pKd 4.8 nM Kd Bioorg. Med. Chem. Lett. (2006) 16: 378-381 [PMID:16260133]
ChEMBL Inhibition bRaf kinase activity B 8.22 pIC50 6 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 378-381 [PMID:16260133]
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium berghei [GtoPdb: 3013]
GtoPdb Parasite liver stage assay - 6.7 pIC50 199 nM IC50 Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426]
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum [GtoPdb: 3013]
GtoPdb Kinase inhibition assay using recombinant PfPKG - 9.4 pIC50 0.4 nM IC50 Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426]
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum NF54 [GtoPdb: 3013]
GtoPdb Parasite exflagellation assay - 6.85 pIC50 141 nM IC50 Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426]
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719]
GtoPdb Parasite growth inhibition assay - 6.96 pIC50 109 nM IC50 Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426]
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum Dd2 [GtoPdb: 3013]
GtoPdb Parasite growth inhibition assay - 6.92 pIC50 120 nM IC50 Cell Chem Biol (2020) 27: 806-816.e8 [PMID:32359426]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]