AN3661 [Ligand Id: 10084] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1643740 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum Ugandan field isolates after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.19 | pIC50 | 64 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCR-3 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum TM90C2B after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction of parasitemia after 48 hrs by flow cytometry | F | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 644-651 [PMID:21195617] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum FCR3 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.52 | pIC50 | 30 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum K1 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.7 | pIC50 | 20 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum 3D7 [GtoPdb: 3076] [UniProtKB: Q8IL83] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.28 | pIC50 | 52 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum Dd2 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.41 | pIC50 | 39 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum HB3 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.25 | pIC50 | 56 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
