AN3661 [Ligand Id: 10084] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1643740
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum FCR3 [GtoPdb: 3076]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum K1 [GtoPdb: 3076]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum 3D7 [GtoPdb: 3076] [UniProtKB: Q8IL83]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum Dd2 [GtoPdb: 3076]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum HB3 [GtoPdb: 3076]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction of parasitemia after 48 hrs by flow cytometry F 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 644-651 [PMID:21195617]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum FCR3 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.52 pIC50 30 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum K1 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.7 pIC50 20 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum 3D7 [GtoPdb: 3076] [UniProtKB: Q8IL83]
GtoPdb Parasite growth inhibition assay - 7.28 pIC50 52 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum Dd2 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.41 pIC50 39 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum HB3 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.25 pIC50 56 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]