AN3661 [Ligand Id: 10084] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1643740
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  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum FCR3 [GtoPdb: 3076]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum K1 [GtoPdb: 3076]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum 3D7 [GtoPdb: 3076] [UniProtKB: Q8IL83]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum Dd2 [GtoPdb: 3076]
  • Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum HB3 [GtoPdb: 3076]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum Ugandan field isolates after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.19 pIC50 64 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR-3 after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum TM90C2B after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay F 7.49 pIC50 32 nM IC50 Eur J Med Chem (2019) 179: 791-804 [PMID:31288128]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction of parasitemia after 48 hrs by flow cytometry F 7.59 pIC50 26 nM IC50 Bioorg Med Chem Lett (2011) 21: 644-651 [PMID:21195617]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum FCR3 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.52 pIC50 30 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum K1 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.7 pIC50 20 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum 3D7 [GtoPdb: 3076] [UniProtKB: Q8IL83]
GtoPdb Parasite growth inhibition assay - 7.28 pIC50 52 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum Dd2 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.41 pIC50 39 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]
Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum HB3 [GtoPdb: 3076]
GtoPdb Parasite growth inhibition assay - 7.25 pIC50 56 nM IC50 Nat Commun (2017) 8: 14574 [PMID:28262680]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]