- Guide to PHARMACOLOGY
Synonyms: Arakoda® | etaquine | Krintafel® | WR238605
tafenoquine is an approved drug (FDA (2018))
Compound class: Synthetic organic
Comment: Tafenoquine is an 8-aminoquinoline derivative that has potent antimalarial activity and is a synthetic analogue of primaquine.
The INN record for tafenoquine indicates that it is a racemic mixture. We show the chemical structure without stereochemistry to represent the mixture. The non-isomeric structure is also represented in the PubChem and ChEMBL entries listed in the links table below, while the two enantiomers forming the racemate are represented by PubChem CID 76969187 and PubChem CID 76969188.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Ligand families/groups||Antimalarial ligands|
|Approved drug?||Yes (FDA (2018))|
|International Nonproprietary Names|
|Arakoda® | etaquine | Krintafel® | WR238605|
|CAS Registry No.||106635-80-7 (source: Scifinder)|
|GtoPdb PubChem SID||374883823|
|Search Google for chemical match using the InChIKey||LBHLFPGPEGDCJG-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||LBHLFPGPEGDCJG|
|Search PubMed clinical trials||tafenoquine|
|Search PubMed titles||tafenoquine|
|Search PubMed titles/abstracts||tafenoquine|
|Search UniChem for chemical match using the InChIKey||LBHLFPGPEGDCJG-UHFFFAOYSA-N|
|Search UniChem for chemicals with the same backbone||LBHLFPGPEGDCJG|