Classification
Compound class	Synthetic organic
Ligand families/groups	Antimalarial ligands
Approved drug?	Yes (FDA (2018))

IUPAC Name

N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine

International Nonproprietary Names
INN number	INN
7835	tafenoquine

Synonyms

Arakoda® | etaquine | Krintafel® | WR238605

Comments

Tafenoquine is an 8-aminoquinoline derivative that has potent antimalarial activity and is a synthetic analogue of primaquine. The INN record for tafenoquine indicates that it is a racemic mixture. We show the chemical structure without stereochemistry to represent the mixture. The non-isomeric structure is also represented in the PubChem and ChEMBL entries listed in the links table below, while the two enantiomers forming the racemate are represented by PubChem CID 76969187 and PubChem CID 76969188. The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.

Database Links
CAS Registry No.	106635-80-7 (source: Scifinder)
ChEMBL Ligand	CHEMBL298470
GtoPdb PubChem SID	374883823
PubChem CID	115358
Search Google for chemical match using the InChIKey	LBHLFPGPEGDCJG-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	LBHLFPGPEGDCJG
Search PubMed clinical trials	tafenoquine
Search PubMed titles	tafenoquine
Search PubMed titles/abstracts	tafenoquine
Search UniChem for chemical match using the InChIKey	LBHLFPGPEGDCJG-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone	LBHLFPGPEGDCJG
Wikipedia	Tafenoquine