ChEMBL ligand: CHEMBL4164243
Plasmodium falciparum pantothenate kinase 1/Pantothenate kinase, putative in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL4295621] [GtoPdb: 3089] [UniProtKB: Q8ILP4] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum pantothenate kinase 1/Pantothenate kinase, putative in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295621] [GtoPdb: 3089] [UniProtKB: Q8ILP4]
ChEMBL	Inhibition of pantothenate kinase in Plasmodium falciparum 3D7 trophozoites using [14C]pantothenate as substrate after 15 mins by TopCount scintillation counting method	B	4.85	pIC50	14000	nM	IC50	Eur J Med Chem (2018) 143: 1139-1147 [PMID:29233590]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in erythrocytes in presence of 1 uM pantothenic acid by SYBR safe-based fluorescence assay	F	4.19	pIC50	64000	nM	IC50	Medchemcomm (2019) 10: 2118-2125 [PMID:32206243]
ChEMBL	Antimalarial activity against blood stage of Plasmodium falciparum in presence of pantothenate by [3H]hypoxanthine incorporation assay	F	4.41	pIC50	39000	nM	IC50	Eur J Med Chem (2018) 143: 1139-1147 [PMID:29233590]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs in presence of 1 uM pantothenate by SYBR green fluorescence-based method	F	4.44	pIC50	36000	nM	IC50	Eur J Med Chem (2018) 143: 1139-1147 [PMID:29233590]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in erythrocytes in presence of 100 uM pantothenic acid and TBA salt form by SYBR safe-based fluorescence assay	F	4.6	pIC50	25000	nM	IC50	Medchemcomm (2019) 10: 2118-2125 [PMID:32206243]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in erythrocytes in presence of 1 uM pantothenic acid and TBA salt form by SYBR safe-based fluorescence assay	F	4.6	pIC50	25000	nM	IC50	Medchemcomm (2019) 10: 2118-2125 [PMID:32206243]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]