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ChEMBL ligand: CHEMBL2058833 (Kaf156, Ganaplacide, KAF156, GNF 156, KAF-156, GNF-156, KAF 156) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG channel expressed in CHO cells by patch clamp assay | B | 4.87 | pIC50 | 13400 | nM | IC50 | J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against Plasmodium falciparum assessed as reduction in parasite growth after 72 hrs by SYBR-green based fluorescence assay | F | 7.9 | pEC50 | 12.6 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green fluorescence assay | F | 8 | pEC50 | 10 | nM | EC50 | J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250] |
ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green fluorescence assay | F | 8.22 | pEC50 | 6 | nM | EC50 | J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250] |
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013] | ||||||||
ChEMBL | Antimalarial activity against Plasmodium vivax assessed as reduction in parasite growth after 72 hrs by SYBR-green based fluorescence assay | F | 8.26 | pEC50 | 5.5 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]