ganaplacide [Ligand Id: 9946] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2058833 (Kaf156, Ganaplacide, KAF156, GNF 156, KAF-156, GNF-156, KAF 156)
  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
1 CHEMBL2058833_lig_chart_1 HERG Human
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
2 CHEMBL2058833_lig_chart_2 Plasmodium falciparum Plasmodium falciparum
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel expressed in CHO cells by patch clamp assay B 4.87 pIC50 13400 nM IC50 J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green fluorescence assay F 8 pEC50 10 nM EC50 J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green fluorescence assay F 8.22 pEC50 6 nM EC50 J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]