ganaplacide [Ligand Id: 9946] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2058833 (Ganaplacide, GNF 156, GNF-156, Kaf156, KAF 156, KAF-156, KAF156) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG channel expressed in CHO cells by patch clamp assay | B | 4.87 | pIC50 | 13400 | nM | IC50 | J Med Chem (2012) 55: 4244-4273 [PMID:22524250] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 transfected with GFP-Luc infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method | F | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2021) 64: 2291-2309 [PMID:33573376] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum assessed as reduction in parasite growth after 72 hrs by SYBR-green based fluorescence assay | F | 7.9 | pEC50 | 12.6 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green fluorescence assay | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2012) 55: 4244-4273 [PMID:22524250] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 | F | 8 | pEC50 | 10 | nM | EC50 | Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green fluorescence assay | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (2012) 55: 4244-4273 [PMID:22524250] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 | F | 8.22 | pEC50 | 6 | nM | EC50 | Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885] |
| Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium vivax assessed as reduction in parasite growth after 72 hrs by SYBR-green based fluorescence assay | F | 8.26 | pEC50 | 5.5 | nM | EC50 | J Med Chem (2019) 62: 10526-10562 [PMID:31385706] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
