ganaplacide [Ligand Id: 9946] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2058833 (Kaf156, Ganaplacide, KAF156, GNF 156, KAF-156, GNF-156, KAF 156)
  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
1 CHEMBL2058833_lig_chart_1 HERG Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
2 CHEMBL2058833_lig_chart_2 Plasmodium falciparum Plasmodium falciparum
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG channel expressed in CHO cells by patch clamp assay B 4.87 pIC50 13400 nM IC50 J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green fluorescence assay F 8 pEC50 10 nM EC50 J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green fluorescence assay F 8.22 pEC50 6 nM EC50 J. Med. Chem. (2012) 55: 4244-4273 [PMID:22524250]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]