Plasmodium cynomolgi

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Malaria Target Species
Plasmodium cynomolgi

Species ID:	107
Name:	Plasmodium cynomolgi
Associated with:	2 targets
	8 ligands

Description
P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).

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Target	Ligand		Sp.	Action	Value	Parameter	Reference
Plasmodium falciparum phosphatidylinositol 4-kinase beta	MMV048		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	5.0 – 7.2	pIC₅₀	4
Plasmodium falciparum phosphatidylinositol 4-kinase beta	MMV048	pIC₅₀ 7.2 (IC₅₀ 6.1x10^-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [4] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay pIC₅₀ 7.2 (IC₅₀ 6.4x10^-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [4] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay pIC₅₀ <5.0 (IC₅₀ >1x10^-5 M) P. cynomolgi assay to assess elimination of hypnozoites (potential as a radical cure) [4] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta	UCT943		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	>8.0	pIC₅₀	1
Plasmodium falciparum phosphatidylinositol 4-kinase beta	UCT943	pIC₅₀ >8.0 (IC₅₀ <1x10^-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [1] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta	KDU691		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	~6.7	pIC₅₀	2
Plasmodium falciparum phosphatidylinositol 4-kinase beta	KDU691	pIC₅₀ ~6.7 (IC₅₀ ~1.96x10^-7 M) P. cynomolgi infected primary rhesus hepatocyte assay to assess activity against hypnozoites [2] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay
Plasmodium falciparum cytochrome b	ELQ-300		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	~7.0	pIC₅₀	3
Plasmodium falciparum cytochrome b	ELQ-300	pIC₅₀ ~7.0 (IC₅₀ ~1x10^-7 M) High-content fluorescence imaging to quantify the number of developing hepatic schizonts in primary rhesus hepatocytes infected with sporozoites from the M strain of P. cynomolgi [3] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay
Unknown MOA	tafenoquine		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	-	-	5
Unknown MOA	tafenoquine	P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay P. cynomolgi infected primary rhesus hepatocyte assay, 70-90% inhibition of hypnozoites at 10µM [5] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay
Unknown MOA	primaquine		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	6.1 – 6.4	pIC₅₀	5
Unknown MOA	primaquine	pIC₅₀ 6.4 (IC₅₀ 3.7x10^-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay pIC₅₀ 6.1 (IC₅₀ 8.4x10^-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [5] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay
Unknown MOA	NPC1161B		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	-	-	5
Unknown MOA	NPC1161B	P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [5] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay
Unknown MOA	bulaquine		Pc Plasmodium cynomolgi P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite). ✖	-	-	-	5
Unknown MOA	bulaquine	P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5] Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite) Description: Parasite liver stage assay P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [5] Lifecycle stages: Plasmodium dormant liver stage (hypnozoite) Description: Parasite liver stage assay

References

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1. Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT et al.. (2018) UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother, 62 (9). [PMID:29941635]

2. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ et al.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, 504 (7479): 248-253. [PMID:24284631]

3. Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE et al.. (2013) Quinolone-3-diarylethers: a new class of antimalarial drug. Sci Transl Med, 5 (177): 177ra37. [PMID:23515079]

4. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med, 9 (387). [PMID:28446690]

5. Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A et al.. (2014) KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob Agents Chemother, 58 (3): 1586-95. [PMID:24366744]