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Plasmodium cynomolgi

Species ID:107
Name:Plasmodium cynomolgi
Associated with:2 targets
8 ligands
Description
P. cynomolgi (Pc) is a malaria parasite that infects non-human primate species with the natural mammalian host being Asian Old World monkeys. Pc is used as a model for human P. vivax infection because these species are phylogenetically close and share a similar lifecycle, including the dormant liver form (hypnozoite).

Interactions

Interactions
Key to terms and symbols Click column headers to sort
Target Ligand Sp. Action Value Parameter Reference
Plasmodium falciparum phosphatidylinositol 4-kinase beta MMV048 Pc - 5.0 – 7.2 pIC50 4
pIC50 7.2 (IC50 6.1x10-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [4]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
pIC50 7.2 (IC50 6.4x10-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [4]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
pIC50 <5.0 (IC50 >1x10-5 M) P. cynomolgi assay to assess elimination of hypnozoites (potential as a radical cure) [4]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta UCT943 Pc - >8.0 pIC50 1
pIC50 >8.0 (IC50 <1x10-8 M) P. cynomolgi assay to assess inhibition of liver stage development (prophylactic activity) [1]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
Plasmodium falciparum phosphatidylinositol 4-kinase beta KDU691 Pc - ~6.7 pIC50 2
pIC50 ~6.7 (IC50 ~1.96x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay to assess activity against hypnozoites [2]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Plasmodium falciparum cytochrome b ELQ-300 Pc - ~7.0 pIC50 3
pIC50 ~7.0 (IC50 ~1x10-7 M) High-content fluorescence imaging to quantify the number of developing hepatic schizonts in primary rhesus hepatocytes infected with sporozoites from the M strain of P. cynomolgi [3]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
Unknown MOA tafenoquine Pc - - - 5
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
P. cynomolgi infected primary rhesus hepatocyte assay, 70-90% inhibition of hypnozoites at 10µM [5]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA primaquine Pc - 6.1 – 6.4 pIC50 5
pIC50 6.4 (IC50 3.7x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
pIC50 6.1 (IC50 8.4x10-7 M) P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [5]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA NPC1161B Pc - - - 5
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [5]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay
Unknown MOA bulaquine Pc - - - 5
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of schizonts at 10µM [5]
Lifecycle stages: Plasmodium liver stage (sporozoite, hepatic schizont, hepatic merozoite)
Description: Parasite liver stage assay
P. cynomolgi infected primary rhesus hepatocyte assay, >90% inhibition of hypnozoites at 10µM [5]
Lifecycle stages: Plasmodium dormant liver stage (hypnozoite)
Description: Parasite liver stage assay

References

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1. Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT et al.. (2018) UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria. Antimicrob Agents Chemother, 62 (9). [PMID:29941635]

2. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ et al.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, 504 (7479): 248-253. [PMID:24284631]

3. Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE et al.. (2013) Quinolone-3-diarylethers: a new class of antimalarial drug. Sci Transl Med, 5 (177): 177ra37. [PMID:23515079]

4. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med, 9 (387). [PMID:28446690]

5. Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A et al.. (2014) KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob Agents Chemother, 58 (3): 1586-95. [PMID:24366744]