KDU691 [Ligand Id: 11863] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3325608 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium cynomolgi (target type: ORGANISM) [ChEMBL: CHEMBL613883] | ||||||||
| ChEMBL | Antiplasmodial activity against hypnozoite liver stage Plasmodium cynomolgi | F | 6.71 | pIC50 | 196 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| ChEMBL | Antiplasmodial activity against schizont liver stage Plasmodium cynomolgi | F | 6.98 | pIC50 | 105 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 PI4K_S1320L+L1418F mutant incubated for 72 hrs by hypoxanthine based scintillation counting method | F | 5.42 | pIC50 | 3785 | nM | IC50 | J Med Chem (2024) 67: 11401-11420 [PMID:38918002] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 PI4K_S743F+H1484Y mutant incubated for 72 hrs by hypoxanthine based scintillation counting method | F | 6.32 | pIC50 | 481 | nM | IC50 | J Med Chem (2024) 67: 11401-11420 [PMID:38918002] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 PI4K_CNV mutant incubated for 72 hrs by hypoxanthine based scintillation counting method | F | 6.51 | pIC50 | 312 | nM | IC50 | J Med Chem (2024) 67: 11401-11420 [PMID:38918002] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 incubated for 72 hrs by hypoxanthine based scintillation counting method | F | 7.08 | pIC50 | 84 | nM | IC50 | J Med Chem (2024) 67: 11401-11420 [PMID:38918002] |
| ChEMBL | Antiplasmodial activity against schizont blood stage Plasmodium falciparum | F | 7.24 | pIC50 | 58 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum harboring PI4K S1320L mutation assessed as reduction in parasitemia incubated for 72 hrs by SYBR green I dye based analysis | F | 7.17 | pEC50 | 67.6 | nM | EC50 | J Med Chem (2024) 67: 1460-1480 [PMID:38214254] |
| ChEMBL | Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum PC26 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.26 | pEC50 | 54.9 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against mefloquine/chloroquine/pyrimethamine resistant Plasmodium falciparum Dd2 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.33 | pEC50 | 46.7 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum FAB9 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.35 | pEC50 | 44.8 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum D10 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.36 | pEC50 | 43.9 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against artemisinin resistant Plasmodium falciparum 803 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.38 | pEC50 | 41.8 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against sulphadoxine-resistant blood stage Plasmodium falciparum 3D7 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.39 | pEC50 | 41.1 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum GB4 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.41 | pEC50 | 39.2 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum C2A infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.47 | pEC50 | 33.7 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against artemisinin and piperaquine-phosphate resistant Plasmodium falciparum 6320 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.47 | pEC50 | 33.6 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum CP286 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.5 | pEC50 | 31.9 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum harboring CARL I1139K mutation assessed as reduction in parasitemia incubated for 72 hrs by SYBR green I dye based analysis | F | 8.01 | pEC50 | 9.8 | nM | EC50 | J Med Chem (2024) 67: 1460-1480 [PMID:38214254] |
| ChEMBL | Antimalarial activity against wild-type Plasmodium falciparum Dd2 assessed as reduction in parasitemia incubated for 72 hrs by SYBR green I dye based analysis | F | 8.22 | pEC50 | 6 | nM | EC50 | J Med Chem (2024) 67: 1460-1480 [PMID:38214254] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum harboring AcAS A597V mutation assessed as reduction in parasitemia incubated for 72 hrs by SYBR green I dye based analysis | F | 8.38 | pEC50 | 4.2 | nM | EC50 | J Med Chem (2024) 67: 1460-1480 [PMID:38214254] |
| Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889] | ||||||||
| ChEMBL | Antiplasmodial activity against blood stage schizont Plasmodium yoelii | F | 7.44 | pIC50 | 36 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 6.71 | pIC50 | ~196 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.52 | pIC50 | 29.9 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite late stage (III–V) gametocyte assay | - | 6.66 | pIC50 | 220 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium yoelii [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 7.44 | pIC50 | 36 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
