KDU691 [Ligand Id: 11863] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3325608
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  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972]
  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972]
  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium yoelii [GtoPdb: 2972]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium cynomolgi (target type: ORGANISM) [ChEMBL: CHEMBL613883]
ChEMBL Antiplasmodial activity against hypnozoite liver stage Plasmodium cynomolgi F 6.71 pIC50 196 nM IC50 ACS Med. Chem. Lett. (2014) 5: 947-950 [PMID:25147620]
ChEMBL Antiplasmodial activity against schizont liver stage Plasmodium cynomolgi F 6.98 pIC50 105 nM IC50 ACS Med. Chem. Lett. (2014) 5: 947-950 [PMID:25147620]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against schizont blood stage Plasmodium falciparum F 7.24 pIC50 58 nM IC50 ACS Med. Chem. Lett. (2014) 5: 947-950 [PMID:25147620]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL Antiplasmodial activity against blood stage schizont Plasmodium yoelii F 7.44 pIC50 36 nM IC50 ACS Med. Chem. Lett. (2014) 5: 947-950 [PMID:25147620]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972]
GtoPdb Parasite liver stage assay - 6.71 pIC50 ~196 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972]
GtoPdb Parasite growth inhibition assay - 7.52 pIC50 29.9 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
GtoPdb Parasite late stage (III–V) gametocyte assay - 6.66 pIC50 220 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium yoelii [GtoPdb: 2972]
GtoPdb Parasite liver stage assay - 7.44 pIC50 36 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]