KDU691 [Ligand Id: 11863] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3325608
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  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972]
  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972]
  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium yoelii [GtoPdb: 2972]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium cynomolgi (target type: ORGANISM) [ChEMBL: CHEMBL613883]
ChEMBL Antiplasmodial activity against hypnozoite liver stage Plasmodium cynomolgi F 6.71 pIC50 196 nM IC50 ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620]
ChEMBL Antiplasmodial activity against schizont liver stage Plasmodium cynomolgi F 6.98 pIC50 105 nM IC50 ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against schizont blood stage Plasmodium falciparum F 7.24 pIC50 58 nM IC50 ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620]
ChEMBL Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum PC26 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.26 pEC50 54.9 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against mefloquine/chloroquine/pyrimethamine resistant Plasmodium falciparum Dd2 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.33 pEC50 46.7 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against chloroquine resistant Plasmodium falciparum FAB9 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.35 pEC50 44.8 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against chloroquine resistant Plasmodium falciparum D10 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.36 pEC50 43.9 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against artemisinin resistant Plasmodium falciparum 803 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.38 pEC50 41.8 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against sulphadoxine-resistant blood stage Plasmodium falciparum 3D7 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.39 pEC50 41.1 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against Plasmodium falciparum GB4 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.41 pEC50 39.2 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum C2A infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.47 pEC50 33.7 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against artemisinin and piperaquine-phosphate resistant Plasmodium falciparum 6320 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.47 pEC50 33.6 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
ChEMBL Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum CP286 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay F 7.5 pEC50 31.9 nM EC50 Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL Antiplasmodial activity against blood stage schizont Plasmodium yoelii F 7.44 pIC50 36 nM IC50 ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972]
GtoPdb Parasite liver stage assay - 6.71 pIC50 ~196 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972]
GtoPdb Parasite growth inhibition assay - 7.52 pIC50 29.9 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
GtoPdb Parasite late stage (III–V) gametocyte assay - 6.66 pIC50 220 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium yoelii [GtoPdb: 2972]
GtoPdb Parasite liver stage assay - 7.44 pIC50 36 nM IC50 Nature (2013) 504: 248-253 [PMID:24284631]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]