KDU691 [Ligand Id: 11863] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3325608 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium cynomolgi (target type: ORGANISM) [ChEMBL: CHEMBL613883] | ||||||||
| ChEMBL | Antiplasmodial activity against hypnozoite liver stage Plasmodium cynomolgi | F | 6.71 | pIC50 | 196 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| ChEMBL | Antiplasmodial activity against schizont liver stage Plasmodium cynomolgi | F | 6.98 | pIC50 | 105 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against schizont blood stage Plasmodium falciparum | F | 7.24 | pIC50 | 58 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| ChEMBL | Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum PC26 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.26 | pEC50 | 54.9 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against mefloquine/chloroquine/pyrimethamine resistant Plasmodium falciparum Dd2 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.33 | pEC50 | 46.7 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum FAB9 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.35 | pEC50 | 44.8 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum D10 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.36 | pEC50 | 43.9 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against artemisinin resistant Plasmodium falciparum 803 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.38 | pEC50 | 41.8 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against sulphadoxine-resistant blood stage Plasmodium falciparum 3D7 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.39 | pEC50 | 41.1 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum GB4 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.41 | pEC50 | 39.2 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum C2A infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.47 | pEC50 | 33.7 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against artemisinin and piperaquine-phosphate resistant Plasmodium falciparum 6320 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.47 | pEC50 | 33.6 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| ChEMBL | Antimalarial activity against pyrimethamine/chloroquine resistant Plasmodium falciparum CP286 infected in human O+ erythrocytes incubated for 72 hrs by SYBR Green 1 dye based fluorescence assay | F | 7.5 | pEC50 | 31.9 | nM | EC50 | Eur J Med Chem (2020) 188: 112012-112012 [PMID:31911293] |
| Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889] | ||||||||
| ChEMBL | Antiplasmodial activity against blood stage schizont Plasmodium yoelii | F | 7.44 | pIC50 | 36 | nM | IC50 | ACS Med Chem Lett (2014) 5: 947-950 [PMID:25147620] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium cynomolgi [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 6.71 | pIC50 | ~196 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.52 | pIC50 | 29.9 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite late stage (III–V) gametocyte assay | - | 6.66 | pIC50 | 220 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
| Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium yoelii [GtoPdb: 2972] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 7.44 | pIC50 | 36 | nM | IC50 | Nature (2013) 504: 248-253 [PMID:24284631] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
