ChEMBL ligand: CHEMBL76 (Chloroquine, Chlorochine, NSC-187208, Aralen)
Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
beta-secretase 1/Beta-secretase 1 in Human [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] There should be some charts here, you may need to enable JavaScript!
Dihydrofolate reductase in Bovine [ChEMBL: CHEMBL1075051] [UniProtKB: P00376] There should be some charts here, you may need to enable JavaScript!
Falcipain 2 in Plasmodium falciparum [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Histidine-rich protein in Plasmodium falciparum [ChEMBL: CHEMBL1923] [UniProtKB: P05227] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum D6 [ChEMBL: CHEMBL2367107] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate FcB1 / Columbia) in Plasmodium falciparum FcB1/Columbia [ChEMBL: CHEMBL612608] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum NF54 [ChEMBL: CHEMBL2367131] There should be some charts here, you may need to enable JavaScript!
Plasmodium knowlesi [ChEMBL: CHEMBL613011] There should be some charts here, you may need to enable JavaScript!
Plasmodium malariae [ChEMBL: CHEMBL613257] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!
Prion protein in Human [ChEMBL: CHEMBL4869] [UniProtKB: P04156] There should be some charts here, you may need to enable JavaScript!
Quinone reductase 2 in Human [ChEMBL: CHEMBL3959] [UniProtKB: P16083] There should be some charts here, you may need to enable JavaScript!
Riboflavin-binding protein in Chicken [ChEMBL: CHEMBL1944489] [UniProtKB: P02752] There should be some charts here, you may need to enable JavaScript!
MRGPRX1 in Human [GtoPdb: 156] [UniProtKB: Q96LB2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 24 hrs by ELISA	B	4.89	pIC50	12800	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
ChEMBL	Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 24 hrs	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem (2018) 26: 2151-2164 [PMID:29559198]
beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA method	B	4.9	pIC50	12700	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
ChEMBL	Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA method	B	5.15	pIC50	7000	nM	IC50	Eur J Med Chem (2018) 159: 104-125 [PMID:30268822]
Dihydrofolate reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
ChEMBL	Inhibition of bovine liver DHFR	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 5396-5406 [PMID:28789907]
ChEMBL	Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPH	B	7.52	pIC50	30.1	nM	IC50	Bioorg Med Chem (2017) 25: 4064-4075 [PMID:28634040]
Falcipain 2 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697672] [UniProtKB: Q9NAW2]
ChEMBL	Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in bacterial growth after 24 hrs by Giemsa staining based assay	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1566-1569 [PMID:29602682]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG expressed in CHO cells	B	5.12	pKi	7500	nM	Ki	ACS Med. Chem. Lett. (2013) 4: 1037-1041 [PMID:24900603]
ChEMBL	Inhibition of human ERG	B	5.6	pIC50	2511.89	nM	IC50	Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.6	pIC50	2500	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of human cloned ERG	B	5.6	pIC50	2500	nM	IC50	J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL	Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mV	B	5.6	pIC50	2500	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 1390-1393 [PMID:25746816]
Histidine-rich protein in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1923] [UniProtKB: P05227]
ChEMBL	Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formation	F	4.12	pIC50	76500	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 3783-3787 [PMID:14552779]
ChEMBL	Inhibition of beta-hematin formation in Plasmodium falciparum	F	4.12	pIC50	75000	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Inhibition of 1-monooleoyl glycerol induced beta-hematin formation	F	4.22	pIC50	60000	nM	IC50	Bioorg. Med. Chem. Lett. (2006) 16: 31-35 [PMID:16263280]
ChEMBL	Inhibition of lipid-induced beta-hematin formation	F	4.33	pIC50	46300	nM	IC50	J. Med. Chem. (2006) 49: 4707-4714 [PMID:16854077]
ChEMBL	Inhibition of beta-hematin formation	F	4.42	pIC50	38000	nM	IC50	J. Med. Chem. (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Inhibition of beta-hematin formation after 16 hrs	F	4.81	pIC50	15400	nM	IC50	Antimicrob. Agents Chemother. (2007) 51: 2842-2847 [PMID:17562796]
ChEMBL	Inhibition of hematin polymerization	F	4.82	pIC50	15000	nM	IC50	J. Med. Chem. (1999) 42: 4630-4639 [PMID:10579825]
ChEMBL	Inhibition of beta-hematin polymerization	B	6.4	pIC50	400	nM	IC50	J. Med. Chem. (2007) 50: 394-398 [PMID:17228883]
ChEMBL	Inhibitory activity against beta-hematin formation	F	7.12	pIC50	76.5	nM	IC50	J. Med. Chem. (2003) 46: 542-557 [PMID:12570376]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay	F	4.8	pIC50	15900	nM	IC50	J. Med. Chem. (2013) 56: 556-567 [PMID:23273038]
ChEMBL	Antiplasmodial activity against liver stage of Plasmodium berghei expressing GFP-Luc infected in HuH7 cells incubated at 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured after 48 hrs by Alamar blue assay	F	4.82	pIC50	>15000	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 610-613 [PMID:23290049]
ChEMBL	Antimalarial activity against exo-erythrocytic form of Plasmodium berghei infected in human HepG2 cells after 48 hrs	F	5	pIC50	>10000	nM	IC50	Eur. J. Med. Chem. (2014) 82: 204-213 [PMID:24904967]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells	F	5.05	pIC50	9000	nM	IC50	J. Med. Chem. (2016) 59: 264-281 [PMID:26640981]
ChEMBL	Antimalarial activity against schizonts of chloroquine-sensitive Plasmodium berghei ANKA 2.34 after 16 hrs	F	7.22	pIC50	60	nM	IC50	Bioorg. Med. Chem. Lett. (2012) 22: 7048-7051 [PMID:23084276]
ChEMBL	Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay	F	5	pEC50	>10000	nM	EC50	J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibition of hematin polymerization in Plasmodium falciparum	F	4.1	pIC50	80000	nM	IC50	J. Med. Chem. (1998) 41: 4360-4364 [PMID:9784111]
ChEMBL	Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay	F	4.22	pIC50	60000	nM	IC50	J. Med. Chem. (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Inhibition of hydrogen peroxide-mediated haem detoxification in Plasmodium falciparum	F	4.43	pIC50	37000	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected in erythrocytes by LDH assay	F	4.53	pIC50	29700	nM	IC50	Bioorg. Med. Chem. (2009) 17: 741-751 [PMID:19084416]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay	F	4.68	pIC50	21000	nM	IC50	J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.72	pIC50	19000	nM	IC50	J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	4.79	pIC50	16300	nM	IC50	J Nat Prod (2018) 81: 41-48 [PMID:29309141]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human O positive erythrocytes assessed as reduction of parasite growth after 24 to 44 hrs by Giemsa staining	F	4.82	pIC50	15000	nM	IC50	Eur. J. Med. Chem. (2013) 67: 158-165 [PMID:23851117]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K14 infected in human red blood cells after 48 hrs by [3H]hypoxanthine incorporation assay	F	4.96	pIC50	11000	nM	IC50	Eur. J. Med. Chem. (2014) 87: 364-371 [PMID:25282260]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 4 & 5)	F	4.97	pIC50	10700	nM	IC50	Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.26	pIC50	5500	nM	IC50	Eur. J. Med. Chem. (2013) 60: 497-502 [PMID:23354072]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum	F	5.52	pIC50	3000	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 1851-1854 [PMID:11459645]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 1536-well format based SYBR green assay	F	5.7	pIC50	2000	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	5.74	pIC50	1828	nM	IC50	Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL	Displacement of chloroquine from Fe(3+) FPIX-loaded membrane	F	5.75	pIC50	1760	nM	IC50	J. Med. Chem. (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 1536-well format based SYBR green assay	F	5.8	pIC50	1600	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 1536-well format based SYBR green assay	F	5.8	pIC50	1600	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antimalarial activity against Plasmodium falciparum infected in human O+ erythrocytes after 48 hrs by HRP2-ELISA method	F	5.99	pIC50	1030	nM	IC50	Bioorg. Med. Chem. (2010) 18: 5626-5633 [PMID:20621497]
ChEMBL	Antimalarial activity against Plasmodium falciparum V1/S infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6	pIC50	>1000	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth	F	6	pIC50	>1000	nM	IC50	J. Med. Chem. (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	6	pIC50	1000	nM	IC50	Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S assessed as inhibition of parasite growth	F	6	pIC50	>1000	nM	IC50	J. Med. Chem. (2015) 58: 4573-4580 [PMID:25906200]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, and mefloquine-resistant Plasmodium falciparum Dd2 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.01	pIC50	980	nM	IC50	J. Nat. Prod. (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Inhibition of chloroquine uptake from intact parasites	F	6.02	pIC50	950	nM	IC50	J. Med. Chem. (2002) 45: 4975-4983 [PMID:12408708]
ChEMBL	In vitro inhibitory activity against multidrug-resistant Plasmodium falciparum W2 Indochina	F	6.05	pIC50	900	nM	IC50	J. Med. Chem. (2002) 45: 3195-3209 [PMID:12109904]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.06	pIC50	879	nM	IC50	J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Plasmodium falciparum VS1 after 24 hrs	F	6.07	pIC50	860	nM	IC50	Bioorg. Med. Chem. (2007) 15: 5551-5562 [PMID:17548196]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 asynchronous cultures infected in human erythrocytes measured after 72 hrs by SYBR Green1 dye based fluorescence assay	F	6.08	pIC50	830	nM	IC50	MedChemComm (2018) 9: 1232-1238
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by pLDH assay	F	6.09	pIC50	810	nM	IC50	J. Med. Chem. (2006) 49: 7088-7094 [PMID:17125261]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth after 24 hrs by [3H]hypoxanthine incorporation assay	F	6.11	pIC50	780	nM	IC50	Eur. J. Med. Chem. (2013) 62: 168-176 [PMID:23353738]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 to 72 hrs by SYBR green-1 assay	F	6.12	pIC50	750	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 6167-6171 [PMID:24080459]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis	F	6.14	pIC50	720	nM	IC50	Eur. J. Med. Chem. (2015) 98: 160-169 [PMID:26005918]
ChEMBL	Antimicrobial activity against Plasmodium falciparum W2 after 72 hrs by LDH activity assay	F	6.14	pIC50	720	nM	IC50	MedChemComm (2013) 4: 1042-1048
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting	F	6.15	pIC50	710	nM	IC50	ACS Med. Chem. Lett. (2012) 3: 373-377 [PMID:24900481]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum Dd2 ring stage cells assessed as reduction parasitemia by Malstat assay	F	6.15	pIC50	710	nM	IC50	Bioorg. Med. Chem. (2012) 20: 5277-5289 [PMID:22858300]
ChEMBL	Antimalarial activity against chloroquine, pyrimethamine, proguanil-resistant Plasmodium falciparum infected in human erythrocytes after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 5962-5964 [PMID:19748781]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Eur. J. Med. Chem. (2010) 45: 616-622 [PMID:19926173]
ChEMBL	Antiplasmodial activity against chloroquinone-resistant Plasmodium falciparum W2	F	6.15	pIC50	700	nM	IC50	Bioorg. Med. Chem. Lett. (2008) 18: 396-401 [PMID:17981462]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of parasite proliferation after 48 hrs	F	6.15	pIC50	700	nM	IC50	Bioorg. Med. Chem. (2010) 18: 6012-6023 [PMID:20638854]
ChEMBL	Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry	F	6.15	pIC50	700	nM	IC50	Bioorg. Med. Chem. (2009) 17: 4313-4322 [PMID:19482476]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected human erythrocytes after 48 hrs by flow cytometry	F	6.15	pIC50	700	nM	IC50	Eur. J. Med. Chem. (2010) 45: 864-869 [PMID:19914747]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.16	pIC50	690	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBCs after 72 hrs by parasite lactate dehydrogenase assay	F	6.17	pIC50	681	nM	IC50	J. Med. Chem. (2012) 55: 10387-10404 [PMID:23145816]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.18	pIC50	665	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.19	pIC50	648.6	nM	IC50	J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR3	F	6.19	pIC50	645	nM	IC50	Bioorg. Med. Chem. Lett. (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometry	F	6.2	pIC50	632	nM	IC50	Eur. J. Med. Chem. (2011) 46: 1757-1767 [PMID:21396743]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA	F	6.2	pIC50	630.6	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimalarial activity against chloroquine-resistant/mefloquine-sensitive Plasmodium falciparum W2 by malaria SYBR green 1-based fluorescence (MSF) assay	F	6.2	pIC50	630	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM93-C1088 infected in human O positive red blood cells assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs	F	6.21	pIC50	620	nM	IC50	J. Nat. Prod. (2011) 74: 74-78 [PMID:21155593]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	6.21	pIC50	616.94	nM	IC50	J. Med. Chem. (2008) 51: 2261-2266 [PMID:18330976]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29 by [3H]hypoxanthine uptake	F	6.22	pIC50	600	nM	IC50	J. Nat. Prod. (2008) 71: 1189-1192 [PMID:18512987]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum indochina W2 assessed as [3H]-hypoxanthine incorporation by liquid scintillation counting analysis	F	6.23	pIC50	595	nM	IC50	Bioorg. Med. Chem. (2015) 23: 2176-2186 [PMID:25801154]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by SYBR test	F	6.23	pIC50	590	nM	IC50	Bioorg. Med. Chem. Lett. (2016) 26: 1881-1884 [PMID:26988303]
ChEMBL	In vitro inhibitory activity against Plasmodium falciparum NF54-R in blood	F	6.24	pIC50	570	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 2773-2776 [PMID:15125930]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes measured after 72 hrs by malstat reagent based LDH release assay	F	6.24	pIC50	570	nM	IC50	ACS Med Chem Lett (2018) 9: 980-985 [PMID:30344903]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs by scintillation counting	F	6.25	pIC50	563	nM	IC50	Bioorg. Med. Chem. (2010) 18: 8085-8091 [PMID:20934349]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2B infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by scintillation counting method	F	6.25	pIC50	561	nM	IC50	J Med Chem (2017) 60: 5889-5908 [PMID:28635296]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 asexual gametocytes	F	6.25	pIC50	560	nM	IC50	Antimicrob. Agents Chemother. (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.25	pIC50	556	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine/sulfadoxine-resistant Plasmodium falciparum W2 infected in human A+ erythrocytes assessed as reduction in parasite growth after 72 hrs by HRP2 detection based ELISA	F	6.26	pIC50	550	nM	IC50	Bioorg. Med. Chem. (2016) 24: 4492-4498 [PMID:27485600]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay	F	6.27	pIC50	540	nM	IC50	J Nat Prod (2017) 80: 3120-3127 [PMID:29182338]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs by [G-3H]-hypoxanthine incorporation assay	F	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum PFB Brazil by [3H]hypoxanthine uptake	F	6.27	pIC50	540	nM	IC50	J. Nat. Prod. (2001) 64: 12-16 [PMID:11170658]
ChEMBL	Growth inhibition of chloroquine-resistant Plasmodium falciparum KI	F	6.27	pIC50	540	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 2075-2077 [PMID:11514142]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2	F	6.27	pIC50	540	nM	IC50	Bioorg. Med. Chem. Lett. (2007) 17: 6434-6438 [PMID:17949976]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum D10	F	6.27	pIC50	540	nM	IC50	Eur. J. Med. Chem. (2010) 45: 3245-3264 [PMID:20466465]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.27	pIC50	538	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay	F	6.28	pIC50	530	nM	IC50	MedChemComm (2013) 4: 724-730
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs	F	6.28	pIC50	527	nM	IC50	J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as growth inhibition after 18 hrs by [3H]-hypoxanthine uptake assay	F	6.28	pIC50	525	nM	IC50	J. Med. Chem. (2015) 58: 3411-3431 [PMID:25654185]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.28	pIC50	525	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.28	pIC50	523	nM	IC50	J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.28	pIC50	523	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Bre1 assessed as inhibition of [3H]hypoxanthine incorporation	F	6.28	pIC50	520	nM	IC50	Bioorg. Med. Chem. (2009) 17: 8032-8039 [PMID:19879150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Bre1 by hypoxanthine uptake	F	6.28	pIC50	520	nM	IC50	Bioorg. Med. Chem. (2007) 15: 3278-3289 [PMID:17339112]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	6.28	pIC50	520	nM	IC50	J Nat Prod (2017) 80: 134-140 [PMID:28055207]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as parasite lactate dehydrogenase activity after 72 hrs by spectrophotometric analysis	F	6.28	pIC50	520	nM	IC50	J. Med. Chem. (2011) 54: 8526-8540 [PMID:22054038]
ChEMBL	Antiparasitic activity against chloroquine-resistant Plasmodium falciparum K1	F	6.28	pIC50	519.3	nM	IC50	J. Med. Chem. (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis	F	6.28	pIC50	519	nM	IC50	MedChemComm (2011) 2: 430-435
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	6.29	pIC50	508	nM	IC50	J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter	F	6.29	pIC50	508	nM