TCMDC-135051 [Ligand Id: 11109] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL531865
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  • Plasmodium falciparum cyclin-dependent-like kinase CLK3 in Plasmodium berghei [GtoPdb: 3105]
  • Plasmodium falciparum cyclin-dependent-like kinase CLK3 in Plasmodium falciparum 3D7 [GtoPdb: 3105] [UniProtKB: Q8IIL5]
  • Plasmodium falciparum cyclin-dependent-like kinase CLK3 in Plasmodium falciparum Dd2 [GtoPdb: 3105]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 incubated for 48 to 52 hrs by SYBR green 1 dye based assay F 5.5 pEC50 3167 nM EC50 J Med Chem (2020) 63: 9300-9315 [PMID:32787140]
ChEMBL Antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 incubated for 48 to 52 hrs by SYBR green 1 dye based assay F 5.6 pEC50 2511.89 nM EC50 J Med Chem (2020) 63: 9300-9315 [PMID:32787140]
Plasmodium falciparum cyclin-dependent-like kinase CLK3 in Plasmodium berghei [GtoPdb: 3105]
GtoPdb - - 6.4 pEC50 400 nM EC50 Science (2019) 365: [PMID:31467193]
Plasmodium falciparum cyclin-dependent-like kinase CLK3 in Plasmodium falciparum 3D7 [GtoPdb: 3105] [UniProtKB: Q8IIL5]
GtoPdb - - 6.49 pEC50 320 nM EC50 Science (2019) 365: [PMID:31467193]
Plasmodium falciparum cyclin-dependent-like kinase CLK3 in Plasmodium falciparum Dd2 [GtoPdb: 3105]
GtoPdb - - 6.95 pEC50 113 nM EC50 Science (2019) 365: [PMID:31467193]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]