compound 34c [PMID: 24641010] [Ligand Id: 9647] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3237438
  • Plasmodium falciparum N-Myristoyltransferase in Plasmodium berghei [GtoPdb: 2955]
  • Plasmodium falciparum N-Myristoyltransferase in Plasmodium falciparum K1 [GtoPdb: 2955]
  • Plasmodium falciparum N-Myristoyltransferase in Plasmodium falciparum NF54 [GtoPdb: 2955]
  • Plasmodium falciparum N-Myristoyltransferase/Glycylpeptide N-tetradecanoyltransferase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2169722] [GtoPdb: 2955] [UniProtKB: Q8ILW6]
  • Plasmodium falciparum N-Myristoyltransferase in Plasmodium falciparum Dd2 [GtoPdb: 2955]
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum N-Myristoyltransferase in Plasmodium berghei [GtoPdb: 2955]
GtoPdb Parasite liver stage assay - 6.43 pEC50 372 nM EC50 J. Med. Chem. (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-Myristoyltransferase in Plasmodium falciparum K1 [GtoPdb: 2955]
GtoPdb Parasite growth inhibition assay - 6.47 pEC50 339 nM EC50 J. Med. Chem. (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-Myristoyltransferase in Plasmodium falciparum NF54 [GtoPdb: 2955]
GtoPdb Parasite growth inhibition assay - 6.63 pEC50 232 nM EC50 J. Med. Chem. (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-Myristoyltransferase/Glycylpeptide N-tetradecanoyltransferase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2169722] [GtoPdb: 2955] [UniProtKB: Q8ILW6]
ChEMBL Inhibition of Plasmodium falciparum N-myristoyltransferase by CPM fluorescence assay B 8.1 pKi 8 nM Ki J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
GtoPdb Enzyme inhibition assay - 8.1 pKi 8 nM Ki J. Med. Chem. (2014) 57: 2773-88 [PMID:24641010]
ChEMBL Inhibition of Plasmodium falciparum N-myristoyltransferase by CPM fluorescence assay B 7.77 pIC50 17 nM IC50 J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
GtoPdb Parasite growth inhibition assay - 6.52 pEC50 302 nM EC50 J. Med. Chem. (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-Myristoyltransferase in Plasmodium falciparum Dd2 [GtoPdb: 2955]
GtoPdb Parasite growth inhibition assay - 6.04 pEC50 916 nM EC50 J. Med. Chem. (2014) 57: 2773-88 [PMID:24641010]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay F 6.43 pEC50 372 nM EC50 J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against blood-stage Plasmodium falciparum NF54 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting F 6.63 pEC50 232 nM EC50 J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimicrobial activity against late stage trophozoite form of Plasmodium falciparum 3D7 infected in RBCs after 48 hrs by SYBR green viability assay F 6.52 pEC50 302 nM EC50 J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL Antimicrobial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting F 6.52 pEC50 302 nM EC50 J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimicrobial activity against blood-stage Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting F 6.47 pEC50 339 nM EC50 J. Med. Chem. (2014) 57: 2773-2788 [PMID:24641010]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]