ChEMBL ligand: CHEMBL3237438
Plasmodium falciparum N-myristoyltransferase in Plasmodium berghei [GtoPdb: 2955] Plasmodium falciparum N-myristoyltransferase in Plasmodium falciparum K1 [GtoPdb: 2955] Plasmodium falciparum N-myristoyltransferase in Plasmodium falciparum NF54 [GtoPdb: 2955] Plasmodium falciparum N-myristoyltransferase/Glycylpeptide N-tetradecanoyltransferase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2169722] [GtoPdb: 2955] [UniProtKB: Q8ILW6] Plasmodium falciparum N-myristoyltransferase in Plasmodium falciparum Dd2 [GtoPdb: 2955] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum N-myristoyltransferase in Plasmodium berghei [GtoPdb: 2955]
GtoPdb	Parasite liver stage assay	-	6.43	pEC50	372	nM	EC50	J Med Chem (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-myristoyltransferase in Plasmodium falciparum K1 [GtoPdb: 2955]
GtoPdb	Parasite growth inhibition assay	-	6.47	pEC50	339	nM	EC50	J Med Chem (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-myristoyltransferase in Plasmodium falciparum NF54 [GtoPdb: 2955]
GtoPdb	Parasite growth inhibition assay	-	6.63	pEC50	232	nM	EC50	J Med Chem (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-myristoyltransferase/Glycylpeptide N-tetradecanoyltransferase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2169722] [GtoPdb: 2955] [UniProtKB: Q8ILW6]
ChEMBL	Inhibition of Plasmodium falciparum N-myristoyltransferase by CPM fluorescence assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
GtoPdb	Enzyme inhibition assay	-	8.1	pKi	8	nM	Ki	J Med Chem (2014) 57: 2773-88 [PMID:24641010]
ChEMBL	Inhibition of Plasmodium falciparum N-myristoyltransferase by CPM fluorescence assay	B	7.77	pIC50	17	nM	IC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
GtoPdb	Parasite growth inhibition assay	-	6.52	pEC50	302	nM	EC50	J Med Chem (2014) 57: 2773-88 [PMID:24641010]
Plasmodium falciparum N-myristoyltransferase in Plasmodium falciparum Dd2 [GtoPdb: 2955]
GtoPdb	Parasite growth inhibition assay	-	6.04	pEC50	916	nM	EC50	J Med Chem (2014) 57: 2773-88 [PMID:24641010]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimicrobial activity against Plasmodium berghei sporozoites infected in 12 hrs compound pretreated human HepG2 cells assessed as reduction in viability of exoerythrocytic forms measured after 48 hrs of incubation by luciferase bioluminescence assay	F	6.43	pEC50	372	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum Dd2 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.04	pEC50	916	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.47	pEC50	339	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antimicrobial activity against late stage trophozoite form of Plasmodium falciparum 3D7 infected in RBCs after 48 hrs by SYBR green viability assay	F	6.52	pEC50	302	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.52	pEC50	302	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]
ChEMBL	Antimicrobial activity against blood-stage Plasmodium falciparum NF54 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting	F	6.63	pEC50	232	nM	EC50	J Med Chem (2014) 57: 2773-2788 [PMID:24641010]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]