dapsone [Ligand Id: 10934] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1043 (Aczone, Dapsone, Dapsonum, Diaminodiphenylsulfone, Diaphenylsulfone, J04BA02, Novophone, NSC-6091, NSC-6091D, Servidapson) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184] | ||||||||
| ChEMBL | Inhibitory activity was determined against dihydrofolate reductase in Pneumocystis carinii. | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
| Dihydropteroate synthetase, putative in Plasmodium berghei str. ANKA (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741265] [UniProtKB: A0A113T0T6] | ||||||||
| ChEMBL | Inhibitory activity against dihydropteroic acid synthase (SYN) from Plasmodium berghei | B | 4.91 | pIC50 | 12410 | nM | IC50 | J Med Chem (2004) 47: 240-253 [PMID:14695838] |
| myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
| ChEMBL | Inhibition of MPO (unknown origin) | B | 6.38 | pIC50 | 420 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1-7 [PMID:30466896] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium vivax infected in human blood incubated for 24 to 36 hrs | F | 5.79 | pIC50 | 1625 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 mins | F | 6.74 | pKi | 183 | nM | Ki | Bioorg Med Chem (2013) 21: 4614-4627 [PMID:23787290] |
| Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase in Plasmodium falciparum [GtoPdb: 3065] | ||||||||
| GtoPdb | Enzyme inhibition assay. | - | 5.22 | pKi | 6000 | nM | Ki | Antimicrob Agents Chemother (1991) 35: 267-71 [PMID:2024960] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
