cipargamin [Ligand Id: 9721] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1082723 (Cipargamin, Cipargamina, Cipargamine, Kae609, KAE-609, KAE609, NITD-609, NITD609)
  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
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  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
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  • Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
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  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
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  • B1 receptor/Bradykinin B1 receptor in Human [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
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  • B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • CCK1 receptor/Cholecystokinin A receptor in Human [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238]
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  • CCK2 receptor/Cholecystokinin B receptor in Human [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
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  • CRF1 receptor/Corticotropin releasing factor receptor 1 in Human [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
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  • CRF2 receptor/Corticotropin releasing factor receptor 2 in Human [ChEMBL: CHEMBL4069] [GtoPdb: 213] [UniProtKB: Q13324]
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  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
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  • ETB receptor/Endothelin receptor ET-B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
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  • Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
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  • Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
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  • GIP receptor/Gastric inhibitory polypeptide receptor in Rat [ChEMBL: CHEMBL5001] [GtoPdb: 248] [UniProtKB: P43219]
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  • ghrelin receptor/Ghrelin receptor in Human [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
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  • glucagon receptor/Glucagon receptor in Human [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871]
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
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  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
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  • H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
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  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
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  • MC3 receptor/Melanocortin receptor 3 in Human [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
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  • MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
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  • motilin receptor/Motilin receptor in Human [ChEMBL: CHEMBL2203] [GtoPdb: 297] [UniProtKB: O43193]
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
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  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
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  • Y1 receptor/Neuropeptide Y receptor type 1 in Human [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
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  • Y2 receptor/Neuropeptide Y receptor type 2 in Human [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
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  • NTS1 receptor/Neurotensin receptor 1 in Human [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989]
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
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  • phosphodiesterase 4D/Phosphodiesterase 4D in Human [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
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  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
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  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
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  • V1A receptor/Vasopressin V1a receptor in Human [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
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  • V2 receptor/Vasopressin V2 receptor in Human [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
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  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum TM91C235 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum NF54 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 7G8 [GtoPdb: 2971]
  • Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum D6 [GtoPdb: 2971]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Binding affinity to human recombinant adenosine 2a receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Binding affinity to human recombinant adenosine 3 receptor B 5.08 pIC50 8300 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Binding affinity to human recombinant alpha 1a receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Binding affinity to human recombinant alpha-2a receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Binding affinity to human recombinant alpha2b receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL Binding affinity to human recombinant alpha2c receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL Binding affinity to human recombinant androgen receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity to human recombinant adrenergic beta-1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity to human recombinant adrenergic beta2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL Binding affinity to human recombinant adrenergic beta3 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
ChEMBL Binding affinity to human recombinant bradykinin B1 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
ChEMBL Binding affinity to human recombinant bradykinin B2 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Binding affinity to human recombinant cannabinoid 1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238]
ChEMBL Binding affinity to human recombinant cholecystokinin A receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239]
ChEMBL Binding affinity to human recombinant cholecystokinin B receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
ChEMBL Binding affinity to human recombinant CRF1 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
CRF2 receptor/Corticotropin releasing factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4069] [GtoPdb: 213] [UniProtKB: Q13324]
ChEMBL Binding affinity to human recombinant CRF2alpha receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Binding affinity to human recombinant COX1 B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Binding affinity to human recombinant COX2 B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Binding affinity to human recombinant opiate delta receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL Binding affinity to human recombinant dopamine D1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity to human recombinant dopamine D2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity to human recombinant dopamine D3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity to human recombinant dopamine D4.4 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL Binding affinity to human recombinant dopamine transporter B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL Binding affinity to human recombinant endothelin A receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
ChEMBL Binding affinity to human recombinant endothelin B receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL Binding affinity to human recombinant ERalpha B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
ChEMBL Binding affinity to human recombinant ERbeta B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor α6 subunit/GABA-A receptor; agonist GABA site in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2109244] [GtoPdb: 404, 410, 412, 408, 406, 405, 411, 407, 409] [UniProtKB: P14867, P18505, P28472, P31644, P34903, P47869, P47870, P48169, Q16445]
ChEMBL Binding affinity to human recombinant GABAA receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
GIP receptor/Gastric inhibitory polypeptide receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5001] [GtoPdb: 248] [UniProtKB: P43219]
ChEMBL Binding affinity to rat Gip receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
ChEMBL Binding affinity to human recombinant Ghrelin receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871]
ChEMBL Binding affinity to human recombinant glucagon receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL Binding affinity to human recombinant glucocorticoid receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL Binding affinity to human recombinant NMDA receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 4.52 pIC50 30440 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Inhibition of human ERG by patch clamp method B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Inhibition of human ERG by binding assay B 4.52 pIC50 >=30000 nM IC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Inhibition of human ERG by patch clamp method B 4.52 pIC50 >=30000 nM IC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Binding affinity to human recombinant histamine H1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL Binding affinity to human recombinant histamine H2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL Binding affinity to human recombinant histamine H3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
ChEMBL Binding affinity to human recombinant niacin receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL Binding affinity to human recombinant opiate kappa receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
MC3 receptor/Melanocortin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
ChEMBL Binding affinity to human recombinant melanocortin MC3 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
MC4 receptor/Melanocortin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
ChEMBL Binding affinity to human recombinant melanocortin MC4 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Binding affinity to human recombinant MAOM B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
motilin receptor/Motilin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2203] [GtoPdb: 297] [UniProtKB: O43193]
ChEMBL Binding affinity to human recombinant motilin receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL Binding affinity to human recombinant opiate mu receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Binding affinity to human recombinant muscarinic M1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL Binding affinity to human recombinant muscarinic M2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Binding affinity to human recombinant muscarinic M3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
ChEMBL Binding affinity to human recombinant neurokinin NK1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Y1 receptor/Neuropeptide Y receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4777] [GtoPdb: 305] [UniProtKB: P25929]
ChEMBL Binding affinity to human recombinant neuropeptide Y1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146]
ChEMBL Binding affinity to human recombinant neuropeptide Y2 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
NTS1 receptor/Neurotensin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4123] [GtoPdb: 309] [UniProtKB: P30989]
ChEMBL Binding affinity to human recombinant neurotensin NT1 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL Binding affinity to human recombinant norepinephrine transporter B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
phosphodiesterase 4D/Phosphodiesterase 4D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL288] [GtoPdb: 1303] [UniProtKB: Q08499]
ChEMBL Binding affinity to human recombinant PDE4D B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay F 7.96 pIC50 10.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control F 8 pIC50 10 nM IC50 Eur J Med Chem (2014) 78: 375-382 [PMID:24699367]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring ATP4 P990R/D124Y double mutant F 8.35 pIC50 4.5 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay F 8.37 pIC50 4.25 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 I203M and I263V mutations after 72 hrs by SYBR green based fluorescence assay F 8.39 pIC50 4.1 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay F 8.41 pIC50 3.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay F 8.43 pIC50 3.7 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay F 8.49 pIC50 3.2 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 A184S and P990Y mutations after 72 hrs by SYBR green based fluorescence assay F 8.55 pIC50 2.8 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against NITD678-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 G223R mutations after 72 hrs by SYBR green based fluorescence assay F 8.55 pIC50 2.8 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay F 8.72 pIC50 1.89 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay F 8.8 pIC50 1.57 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 8.85 pIC50 1.4 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against pyrimethamine-resistant Plasmodium falciparum 7G8 after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 8.92 pIC50 1.2 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 after 48 hrs incubation by [3H]hypoxanthin incorporation assay F 9 pIC50 1 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing wild type ATP4 after 72 hrs by SYBR green based fluorescence assay F 9.04 pIC50 0.92 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine assay F 9.05 pIC50 0.9 nM IC50 J Med Chem (2010) 53: 5155-5164 [PMID:20568778]
ChEMBL Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 F 9.05 pIC50 0.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM91C235 after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 9.05 pIC50 0.9 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antiplasmodial activity against Plasmodium falciparum assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis F 9.05 pIC50 0.9 nM IC50 ACS Med Chem Lett (2013) 4: 989-993 [PMID:24159368]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and expressing parental ATP4 after 72 hrs by SYBR green based fluorescence assay F 9.07 pIC50 0.85 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs incubation by [3H]hypoxanthin incorporation assay F 9.15 pIC50 0.7 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against wild type Plasmodium falciparum Dd2 F 9.22 pIC50 0.6 nM IC50 J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 9.22 pIC50 0.6 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 F 9.22 pIC50 0.6 nM IC50 Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885]
ChEMBL Antiplasmodial activity against asexual blood stage Plasmodium falciparum assessed as inhibition of parasitic growth F 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL Antimalarial activity against Plasmodium falciparum assessed as [35S]Met/Cys incorporation by SYBR green based fluorescence assay F 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 after 48 hrs incubation by [3H]hypoxanthin incorporation assay F 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 F 9.3 pIC50 0.5 nM IC50 Eur J Med Chem (2021) 210: 112955-112955 [PMID:33131885]
ChEMBL Antimalarial activity against chloroquine, mefloquine and pyrimethamine-resistant Plasmodium falciparum TM90C2A after 48 hrs incubation by [3H]hypoxanthine incorporation assay F 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in parasitemia incubated for 48 hrs by [3H]-hypoxanthine based liquid scintillation counting analysis F 9.3 pIC50 0.5 nM IC50 Eur J Med Chem (2023) 252: 115247-115247 [PMID:36931118]
ChEMBL Antiplasmodial activity against sexual blood stage Plasmodium falciparum assessed as inhibition of parasitic growth F 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem (2023) 88-89: 117339-117339 [PMID:37236020]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green based fluorescence assay F 9.36 pIC50 0.44 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
ChEMBL Antiplasmodial activity against blood stage form of Plasmodium falciparum NF54 F 9 pEC50 1 nM EC50 J Med Chem (2013) 56: 7741-7749 [PMID:23927720]
ChEMBL Antiplasmodial activity against drug-sensitive Plasmodium falciparum 3D7 F 9.15 pEC50 0.7 nM EC50 Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum 7G8 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum TM90C2A infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum TM91C235 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum V1/S infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
ChEMBL Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs followed by addition of [3H]-hypoxanthine and measured after 24 hrs by liquid scintillation counting method F 9.3 pEC50 0.5 nM EC50 J Med Chem (2019) 62: 10526-10562 [PMID:31385706]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to human recombinant serotonin 5-HT1A receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity to human recombinant serotonin 5-HT2A receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Binding affinity to human recombinant serotonin 5-HT2B receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity to human recombinant serotonin 5HT2C receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Binding affinity to human recombinant serotonin 5HT3 receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Binding affinity to human recombinant serotonin transporter B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Binding affinity to human recombinant thromboxane A2 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL Binding affinity to human recombinant angiotensin2 AT1 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288]
ChEMBL Binding affinity to human recombinant vasopressin V1a receptor B 5 pIC50 >10000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
V2 receptor/Vasopressin V2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1790] [GtoPdb: 368] [UniProtKB: P30518]
ChEMBL Binding affinity to human recombinant vasopressin V2 receptor B 4.52 pIC50 >30000 nM IC50 Science (2010) 329: 1175-1180 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum TM91C235 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9.05 pIC50 0.9 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum K1 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9.22 pIC50 0.6 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum NF54 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9.3 pIC50 0.5 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 3D7 [GtoPdb: 2971] [UniProtKB: A0A143ZZK9]
GtoPdb Parasite growth inhibition assay - 9.15 pIC50 0.7 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum 7G8 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 8.92 pIC50 1.2 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase in Plasmodium falciparum D6 [GtoPdb: 2971]
GtoPdb Parasite growth inhibition assay - 9 pIC50 1 nM IC50 Science (2010) 329: 1175-80 [PMID:20813948]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]