FNDR-20123 [Ligand Id: 11797] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4090165 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC1 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC2 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 7.54 | pIC50 | 29 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC3 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC8 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 6.55 | pIC50 | 280 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| ChEMBL | Inhibition of recombinant human HDAC6 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum TM90C2B [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.88 | pIC50 | 13.26 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite dual gamete formation assay (DGFA) | - | 6.72 | pIC50 | 190 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum K1 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.72 | pIC50 | 19.05 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum NF54 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.6 | pIC50 | 25.27 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum 3D7 [GtoPdb: 3072] [UniProtKB: Q7K6A1] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.39 | pIC50 | 41 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum 7G8 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.84 | pIC50 | 14.36 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum Dd2 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.76 | pIC50 | 17.5 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
