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ChEMBL ligand: CHEMBL147806 (Gsk-369796, GSK369796) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human cloned ERG | B | 5.12 | pIC50 | 7500 | nM | IC50 | J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 7.48 | pIC50 | 32.75 | nM | IC50 | J. Med. Chem. (2003) 46: 4933-4945 [PMID:14584944] |
ChEMBL | In vitro antimalarial activity against Plasmodium falciparum HB | F | 7.52 | pIC50 | 30.03 | nM | IC50 | J. Med. Chem. (2003) 46: 4933-4945 [PMID:14584944] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | F | 7.9 | pIC50 | 12.6 | nM | IC50 | J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | F | 7.95 | pIC50 | 11.2 | nM | IC50 | J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | F | 7.88 | pIC50 | 13.2 | nM | IC50 | J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]