GSK369796 [Ligand Id: 10411] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL147806 (Gsk-369796, GSK369796)
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human cloned ERG B 5.12 pIC50 7500 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 7.48 pIC50 32.75 nM IC50 J. Med. Chem. (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum HB F 7.52 pIC50 30.03 nM IC50 J. Med. Chem. (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.9 pIC50 12.6 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.95 pIC50 11.2 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.88 pIC50 13.2 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]