GSK369796 [Ligand Id: 10411] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL147806 (Gsk-369796, GSK369796)
  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 0 pki data point
1 CHEMBL147806_lig_chart_1 HERG Human
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
2 CHEMBL147806_lig_chart_2 Plasmodium falciparum Plasmodium falciparum
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
  • This target only has 0 pki data point
3 CHEMBL147806_lig_chart_3 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human cloned ERG B 5.12 pIC50 7500 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 7.48 pIC50 32.75 nM IC50 J. Med. Chem. (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum HB F 7.52 pIC50 30.03 nM IC50 J. Med. Chem. (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.9 pIC50 12.6 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.95 pIC50 11.2 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.88 pIC50 13.2 nM IC50 J. Med. Chem. (2009) 52: 1408-1415 [PMID:19222165]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]