GSK369796 [Ligand Id: 10411] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL147806 (BDBM50134936, CHEMBL147806, Gsk369796, Gsk-369796, GSK369796, GSK 369796, Ntbisq, N-tert-butylisoquine, N-tert-butyl isoquine, ZINC1912685)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human cloned ERG B 5.12 pIC50 7500 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 7.48 pIC50 32.75 nM IC50 J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum HB F 7.52 pIC50 30.03 nM IC50 J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.9 pIC50 12.6 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.95 pIC50 11.2 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.88 pIC50 13.2 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]