GSK369796 [Ligand Id: 10411] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL147806 (BDBM50134936, CHEMBL147806, Gsk-369796, Gsk369796, GSK 369796, GSK369796, Ntbisq, N-tert-butyl isoquine, N-tert-butylisoquine, ZINC1912685)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human cloned ERG B 5.12 pIC50 7500 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 7.48 pIC50 32.75 nM IC50 J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum HB F 7.52 pIC50 30.03 nM IC50 J Med Chem (2003) 46: 4933-4945 [PMID:14584944]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.88 pIC50 13.2 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.9 pIC50 12.6 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake F 7.95 pIC50 11.2 nM IC50 J Med Chem (2009) 52: 1408-1415 [PMID:19222165]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]