- Guide to PHARMACOLOGY
Synonyms: Bactroban® | BRL-4910A | BRL-4910F | Centany® | pseudomonic acid
mupirocin is an approved drug (FDA (1987), UK (1998))
Compound class: Synthetic organic
Comment: Mupirocin was initially isolated from Pseudomonas fluorescens . It is an unsaturated ester of 9-hydroxynonanoic acid. Functionally, it binds to bacterial isoleucyl-tRNA synthetase and disrupts isoleucine incorporation into bacterial proteins. This is a unique mechanism of action.
Isoleucine utilization has also been shown to be an essential pathway in P. falciparum and a potential target for antimalarial drug discovery . The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Ligand families/groups||Antimalarial ligands|
|Approved drug?||Yes (FDA (1987), UK (1998))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|Bactroban® | BRL-4910A | BRL-4910F | Centany® | pseudomonic acid|
|Antibiotic DB||Mupirocin, pseudomonic acid|
|CAS Registry No.||12650-69-0 (source: WHO INN record)|
|GtoPdb PubChem SID||405560357|
|RCSB PDB Ligand||MRC|
|Search Google for chemical match using the InChIKey||MINDHVHHQZYEEK-HBBNESRFSA-N|
|Search Google for chemicals with the same backbone||MINDHVHHQZYEEK|
|Search PubMed clinical trials||mupirocin|
|Search PubMed titles||mupirocin|
|Search PubMed titles/abstracts||mupirocin|
|UniChem Compound Search for chemical match using the InChIKey||MINDHVHHQZYEEK-HBBNESRFSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||MINDHVHHQZYEEK-HBBNESRFSA-N|