quinine [Ligand Id: 2510] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL170 (NSC-192949, Quinine, WR297608) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model | B | 4.92 | pKi | 12000 | nM | Ki | J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351] |
| ChEMBL | TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells | F | 4.06 | pIC50 | 87600 | nM | IC50 | Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514] |
| ChEMBL | TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells | F | 4.13 | pIC50 | 74400 | nM | IC50 | Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514] |
| ChEMBL | TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells | F | 4.65 | pIC50 | 22600 | nM | IC50 | Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514] |
| ChEMBL | Inhibition of P-gp-mediated Rhodamine-123 efflux in human MCF-7/DOX cells assessed as Rhodamine-123 accumulation preincubated for 15 mins followed by Rhodamine-123 addition measured after 0.5 to 4 hrs by fluorescence assay | B | 5.77 | pIC50 | 1700 | nM | IC50 | Eur J Med Chem (2019) 176: 268-291 [PMID:31103904] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.27 | pIC50 | 54000 | nM | IC50 | Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 5.67 | pIC50 | 2123 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT K14 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 5.88 | pIC50 | 1310 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09A41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 5.89 | pIC50 | 1295 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 5.95 | pIC50 | 1128 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B7 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 5.96 | pIC50 | 1099 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis | F | 5.97 | pIC50 | 1068 | nM | IC50 | MedChemComm (2011) 2: 430-435 |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT 9996 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 5.98 | pIC50 | 1039 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT K4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 5.99 | pIC50 | 1034 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B2 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 5.99 | pIC50 | 1016 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.01 | pIC50 | 969 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.02 | pIC50 | 953 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis | F | 6.04 | pIC50 | 917 | nM | IC50 | MedChemComm (2011) 2: 430-435 |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N35 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.04 | pIC50 | 905 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-46 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.05 | pIC50 | 894 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.05 | pIC50 | 886 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-3 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.06 | pIC50 | 875 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-8 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.06 | pIC50 | 874 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.06 | pIC50 | 870 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.07 | pIC50 | 853 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND repeat and His/Asp ratio 7:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.08 | pIC50 | 837 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum after 48 hrs | F | 6.08 | pIC50 | 826 | nM | IC50 | Eur. J. Med. Chem. (2016) 112: 270-279 [PMID:26900659] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-35 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.09 | pIC50 | 821 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND repeat and His/Asp ratio 6:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.12 | pIC50 | 767 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B60 harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.12 | pIC50 | 767 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum ms4760-7 assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.12 | pIC50 | 764 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum W2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.14 | pIC50 | 720 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09A10 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.15 | pIC50 | 716 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N66 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.15 | pIC50 | 711 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.15 | pIC50 | 710 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.16 | pIC50 | 688.7 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum W2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.16 | pIC50 | 686 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.17 | pIC50 | 683.9 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-58 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.17 | pIC50 | 680 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.17 | pIC50 | 670 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.18 | pIC50 | 665.3 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND repeat and His/Asp ratio 5:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.18 | pIC50 | 661 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.19 | pIC50 | 650 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.19 | pIC50 | 650 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-11 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.2 | pIC50 | 629 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.2 | pIC50 | 626.6 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum PA harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.2 | pIC50 | 625 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.21 | pIC50 | 619.4 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum 7G8 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034C 1042D 1246Y and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.21 | pIC50 | 619 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis | F | 6.22 | pIC50 | 608 | nM | IC50 | MedChemComm (2011) 2: 430-435 |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.22 | pIC50 | 607 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT A4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.22 | pIC50 | 605 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.22 | pIC50 | 604 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum Dd2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.22 | pIC50 | 602 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT K2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.22 | pIC50 | 599 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B72 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.23 | pIC50 | 583 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis | F | 6.23 | pIC50 | 583 | nM | IC50 | MedChemComm (2011) 2: 430-435 |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum ms4760-6 assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.24 | pIC50 | 582 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND repeat and His/Asp ratio 5:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.24 | pIC50 | 580 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum FCM29 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.24 | pIC50 | 580 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B63 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.24 | pIC50 | 579 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT L1 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.24 | pIC50 | 575 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-34 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.24 | pIC50 | 574 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.24 | pIC50 | 571 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 6.24 | pIC50 | 571 | nM | IC50 | J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum isolate AK127 | F | 6.24 | pIC50 | 569.5 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09A9 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.25 | pIC50 | 562 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum isolate AK182 | F | 6.26 | pIC50 | 549.2 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.26 | pIC50 | 543.3 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.27 | pIC50 | 543 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.27 | pIC50 | 543 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 6.27 | pIC50 | 543 | nM | IC50 | J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.27 | pIC50 | 543 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.27 | pIC50 | 538 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N22 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.27 | pIC50 | 535 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.27 | pIC50 | 530.9 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N44 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.29 | pIC50 | 514 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N78 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.29 | pIC50 | 513 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-25 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.3 | pIC50 | 502 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT Bres harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.3 | pIC50 | 500 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N72 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.3 | pIC50 | 500 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.3 | pIC50 | 495.5 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum isolate AK227 | F | 6.31 | pIC50 | 495.3 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285] |
| ChEMBL | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA | F | 6.31 | pIC50 | 490.8 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N33 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.31 | pIC50 | 490 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N64 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.32 | pIC50 | 475 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-28 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.33 | pIC50 | 473 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F08B53 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.33 | pIC50 | 468 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes 5,34 carrying4 copies of DNNND repeat and His/Asp ratio 5:8 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.34 | pIC50 | 462 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-7 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.34 | pIC50 | 456 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT 6311 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.34 | pIC50 | 453 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09N58 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.35 | pIC50 | 448 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-23 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.35 | pIC50 | 447 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-31 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.36 | pIC50 | 433 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35 | F | 6.37 | pIC50 | 431 | nM | IC50 | Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.37 | pIC50 | 428 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 6.37 | pIC50 | 428 | nM | IC50 | J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-56 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.37 | pIC50 | 427 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs | F | 6.37 | pIC50 | 421.7 | nM | IC50 | J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT Vol harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.38 | pIC50 | 421 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake | F | 6.38 | pIC50 | 413 | nM | IC50 | J. Nat. Prod. (2001) 64: 12-16 [PMID:11170658] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake | F | 6.38 | pIC50 | 413 | nM | IC50 | J. Nat. Prod. (2002) 65: 1381-1386 [PMID:12398531] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum K1 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.39 | pIC50 | 407 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-42 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.41 | pIC50 | 388 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2. | F | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 2681-2683 [PMID:12217353] |
| ChEMBL | Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay | F | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 2159-2161 [PMID:12798326] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes | F | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668] |
| ChEMBL | Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes | F | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg. Med. Chem. Lett. (2001) 11: 423-424 [PMID:11212126] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F09A61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.43 | pIC50 | 373 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum Feng harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.43 | pIC50 | 371 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum IMT 31 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.43 | pIC50 | 371 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake | F | 6.43 | pIC50 | 370 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 1351-1355 [PMID:11992775] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-13 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.44 | pIC50 | 365 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum FCR3 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting | F | 6.48 | pIC50 | 334 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum isolate CDA-1553 | F | 6.48 | pIC50 | 333.3 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-47 harboring pfnhe1 ms4760 haplotype 20 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.49 | pIC50 | 324 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.49 | pIC50 | 322 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum F07-9 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.49 | pIC50 | 321 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining | F | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg. Med. Chem. (2012) 20: 3292-3297 [PMID:22512909] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay | F | 6.49 | pIC50 | 320 | nM | IC50 | Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antimicrobial activity against Plasmodium falciparum HB3 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay | F | 6.5 | pIC50 | 319 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 6.5 | pIC50 | 314 | nM | IC50 | J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 6.5 | |||||