quinine [Ligand Id: 2510] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL170 ((8s,9r)-6'-methoxycinchonan-9-ol, Chininum purum, NSC-192949, Quinine, Rezquin, WR297608)
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
  • Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
  • Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
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  • Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
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  • Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
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  • Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
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  • Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
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  • Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model B 4.92 pKi 12000 nM Ki J Med Chem (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells F 4.06 pIC50 87600 nM IC50 Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells F 4.13 pIC50 74400 nM IC50 Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells F 4.65 pIC50 22600 nM IC50 Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL Inhibition of P-gp-mediated Rhodamine-123 efflux in human MCF-7/DOX cells assessed as Rhodamine-123 accumulation preincubated for 15 mins followed by Rhodamine-123 addition measured after 0.5 to 4 hrs by fluorescence assay B 5.77 pIC50 1700 nM IC50 Eur J Med Chem (2019) 176: 268-291 [PMID:31103904]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.27 pIC50 54000 nM IC50 Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.67 pIC50 2123 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT K14 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 5.88 pIC50 1310 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.89 pIC50 1295 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.95 pIC50 1128 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B7 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.96 pIC50 1099 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis F 5.97 pIC50 1068 nM IC50 Medchemcomm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 9996 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 5.98 pIC50 1039 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT K4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 5.99 pIC50 1034 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B2 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.99 pIC50 1016 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.01 pIC50 969 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.02 pIC50 953 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis F 6.04 pIC50 917 nM IC50 Medchemcomm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N35 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.04 pIC50 905 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-46 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.05 pIC50 894 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.05 pIC50 886 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-3 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.06 pIC50 875 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-8 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.06 pIC50 874 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.06 pIC50 870 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.07 pIC50 853 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND repeat and His/Asp ratio 7:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.08 pIC50 837 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against Plasmodium falciparum K1 F 6.08 pIC50 830 nM IC50 Eur J Med Chem (2023) 256: 115458-115458 [PMID:37163950]
ChEMBL Antimalarial activity against Plasmodium falciparum after 48 hrs F 6.08 pIC50 826 nM IC50 Eur J Med Chem (2016) 112: 270-279 [PMID:26900659]
ChEMBL Antimalarial activity against synchronized ring stage chloroquine-sensitive Plasmodium falciparum assessed as parasite growth inhibition incubated for 48 hrs in presence of 10% human plasma by hypoxanthine assay F 6.08 pIC50 826 nM IC50 Bioorg Med Chem Lett (2021) 38: 127855-127855 [PMID:33609655]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-35 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.09 pIC50 821 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND repeat and His/Asp ratio 6:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.12 pIC50 767 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B60 harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.12 pIC50 767 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum ms4760-7 assessed as growth inhibition after 48 hrs by scintillation counting F 6.12 pIC50 764 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum W2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.14 pIC50 720 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A10 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.15 pIC50 716 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N66 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.15 pIC50 711 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.15 pIC50 710 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.16 pIC50 688.7 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum W2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.16 pIC50 686 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.17 pIC50 683.9 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-58 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.17 pIC50 680 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.17 pIC50 670 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.18 pIC50 665.3 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND repeat and His/Asp ratio 5:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.18 pIC50 661 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.19 pIC50 650 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.19 pIC50 650 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.19 pIC50 650 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay F 6.2 pIC50 632.7 nM IC50 Eur J Med Chem (2015) 100: 10-17 [PMID:26063305]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-11 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.2 pIC50 629 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.2 pIC50 626.6 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum PA harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.2 pIC50 625 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.21 pIC50 619.4 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum 7G8 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034C 1042D 1246Y and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.21 pIC50 619 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis F 6.22 pIC50 608 nM IC50 Medchemcomm (2011) 2: 430-435
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.22 pIC50 607 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT A4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.22 pIC50 605 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.22 pIC50 604 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum Dd2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.22 pIC50 602 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as intraerythrocytic growth inhibition F 6.22 pIC50 600 nM IC50 RSC Med Chem (2023) 14: 715-733 [PMID:37122550]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT K2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.22 pIC50 599 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B72 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.23 pIC50 583 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis F 6.23 pIC50 583 nM IC50 Medchemcomm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum ms4760-6 assessed as growth inhibition after 48 hrs by scintillation counting F 6.24 pIC50 582 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND repeat and His/Asp ratio 5:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.24 pIC50 580 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum FCM29 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.24 pIC50 580 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B63 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.24 pIC50 579 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT L1 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.24 pIC50 575 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-34 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.24 pIC50 574 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.24 pIC50 571 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.24 pIC50 571 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK127 F 6.24 pIC50 569.5 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A9 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.25 pIC50 562 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK182 F 6.26 pIC50 549.2 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.26 pIC50 543.3 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.27 pIC50 543 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.27 pIC50 543 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.27 pIC50 543 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.27 pIC50 543 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.27 pIC50 538 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N22 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.27 pIC50 535 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.27 pIC50 530.9 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N44 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.29 pIC50 514 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N78 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.29 pIC50 513 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as parasitic growth inhibition incubated for 72 hrs by SYBR Green staining based fluorescence analysis F 6.3 pIC50 504 nM IC50 Eur J Med Chem (2023) 256: 115458-115458 [PMID:37163950]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-25 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.3 pIC50 502 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N72 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.3 pIC50 500 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT Bres harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.3 pIC50 500 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.3 pIC50 495.5 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK227 F 6.31 pIC50 495.3 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA F 6.31 pIC50 490.8 nM IC50 Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N33 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.31 pIC50 490 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N64 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.32 pIC50 475 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite growth measured after 72 hrs by HRP2-ELISA F 6.32 pIC50 473.9 nM IC50 Eur J Med Chem (2022) 228: 113981-113981 [PMID:34782182]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-28 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.33 pIC50 473 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B53 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.33 pIC50 468 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes 5,34 carrying4 copies of DNNND repeat and His/Asp ratio 5:8 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.34 pIC50 462 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-7 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.34 pIC50 456 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 6311 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.34 pIC50 453 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N58 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.35 pIC50 448 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-23 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.35 pIC50 447 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-31 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.36 pIC50 433 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35 F 6.37 pIC50 431 nM IC50 Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.37 pIC50 428 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.37 pIC50 428 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-56 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.37 pIC50 427 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.37 pIC50 421.7 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT Vol harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.38 pIC50 421 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake F 6.38 pIC50 413 nM IC50 J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake F 6.38 pIC50 413 nM IC50 J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL Antimicrobial activity against Plasmodium falciparum K1 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.39 pIC50 407 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-42 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.41 pIC50 388 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2. F 6.42 pIC50 380 nM IC50 Bioorg Med Chem Lett (2002) 12: 2681-2683 [PMID:12217353]
ChEMBL Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes F 6.42 pIC50 380 nM IC50 Bioorg Med Chem Lett (2001) 11: 423-424 [PMID:11212126]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes F 6.42 pIC50 380 nM IC50 Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay F 6.42 pIC50 380 nM IC50 Bioorg Med Chem Lett (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.43 pIC50 373 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 31 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.43 pIC50 371 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum Feng harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.43 pIC50 371 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake F 6.43 pIC50 370 nM IC50 Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-13 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.44 pIC50 365 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum FCR3 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.48 pIC50 334 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate CDA-1553 F 6.48 pIC50 333.3 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-47 harboring pfnhe1 ms4760 haplotype 20 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.49 pIC50 324 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.49 pIC50 322 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-9 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.49 pIC50 321 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay F 6.49 pIC50 320 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining F 6.49 pIC50 320 nM IC50 Bioorg Med Chem (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL Antimicrobial activity against Plasmodium falciparum HB3 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.5 pIC50 319 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.5 pIC50 314 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.5 pIC50 314 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes1,18 carrying 2 copies of DNNND repeat and His/Asp ratio 7:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.51 pIC50 312 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-10 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.51 pIC50 306 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B32 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.52 pIC50 302 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 96-well format based SYBR green assay F 6.52 pIC50 300 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimicrobial activity against Plasmodium falciparum PF18 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.52 pIC50 300 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.53 pIC50 298 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK150 D-0 F 6.53 pIC50 296.6 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.54 pIC50 290 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N68 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.54 pIC50 288 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum F 6.54 pIC50 286 nM IC50 Eur J Med Chem (2020) 205: 112652-112652 [PMID:32771798]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N18 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.55 pIC50 284 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.55 pIC50 282 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA F 6.56 pIC50 276 nM IC50 Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.57 pIC50 272 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 10336 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.57 pIC50 271 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK249 F 6.57 pIC50 270.4 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK121 F 6.57 pIC50 270.2 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.57 pIC50 270 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20/ Ghana by [3H]hypoxanthine uptake F 6.57 pIC50 269 nM IC50 J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum FCA 20 Ghana by [3H]hypoxanthine uptake F 6.57 pIC50 269 nM IC50 J Nat Prod (2001) 64: 12-16 [PMID:11170658]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 infected in human erythrocytes by Giemsa staining analysis F 6.57 pIC50 267.92 nM IC50 Bioorg Med Chem (2019) 27: 3574-3586 [PMID:31272837]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B40 harboring pfnhe1 ms4760 haplotype 21 carrying 1 copy of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.59 pIC50 260 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 35 carrying 1 copy of DNNND repeat and His/Asp ratio 5:2 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.59 pIC50 260 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A21 harboring pfnhe1 ms4760 haplotype 18 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.59 pIC50 258 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay F 6.6 pIC50 254 nM IC50 J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs F 6.6 pIC50 250 nM IC50 J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfmdr1-86 mutant gene with 2 DNNND repeat F 6.6 pIC50 249 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A54 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.61 pIC50 243 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.62 pIC50 240 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA F 6.63 pIC50 236.1 nM IC50 Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfcrt-76 mutant gene with 2 DNNND repeat F 6.63 pIC50 234 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK158 F 6.63 pIC50 234 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK167 F 6.64 pIC50 227 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring 2 DNNND repeat F 6.64 pIC50 227 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND repeat and His/Asp ratio 6:2 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.65 pIC50 223 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCM29 by SYBR green assay F 6.66 pIC50 220 nM IC50 Bioorg Med Chem (2009) 17: 2871-2876 [PMID:19282186]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B9 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.66 pIC50 218 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay F 6.67 pIC50 215 nM IC50 J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfcrt gene with 2 DNNND repeat F 6.68 pIC50 211 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK222 F 6.68 pIC50 210.5 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 10500 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.68 pIC50 210 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfmdr1 gene F 6.68 pIC50 208 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK152 D-56 F 6.68 pIC50 207.7 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 16116 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.69 pIC50 204 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-50 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.69 pIC50 204 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake F 6.7 pIC50 200 nM IC50 J Nat Prod (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay F 6.7 pIC50 199 nM IC50 J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58 F 6.7 pIC50 199 nM IC50 Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-59 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.71 pIC50 197 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay F 6.71 pIC50 197 nM IC50 J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N1 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.72 pIC50 191 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum SM harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.73 pIC50 188 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring 1 DNNND repeat F 6.74 pIC50 182 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK062 F 6.74 pIC50 181.5 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum Nigerian assessed as [3H]hypoxanthine uptake after 48 hrs by liquid scintillation counting F 6.74 pIC50 180 nM IC50 Eur J Med Chem (2009) 44: 4778-4782 [PMID:19747753]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes measured after 48 hrs by Malstat/nitroblue tetrazolium/phenazine ethosulphate reagent based LDH assay F 6.74 pIC50 180 nM IC50 Bioorg Med Chem Lett (2017) 27: 460-465 [PMID:28027871]
ChEMBL Antimicrobial activity against Plasmodium falciparum FCC1/HN harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.75 pIC50 179 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis F 6.75 pIC50 178 nM IC50 Medchemcomm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum ms4760-2 assessed as growth inhibition after 48 hrs by scintillation counting F 6.75 pIC50 178 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum ms4760-3 assessed as growth inhibition after 48 hrs by scintillation counting F 6.75 pIC50 178 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCR-3 assessed as growth inhibition after 24 hrs by [3H]-hypoxanthine incorporation assay F 6.77 pIC50 170 nM IC50 Bioorg Med Chem (2013) 21: 3080-3089 [PMID:23602620]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfcrt-76 mutant gene F 6.79 pIC50 164 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as reduction in parasite growth incubated for 36 hrs by Giemsa staining based microscopic analysis F 6.79 pIC50 161 nM IC50 Eur J Med Chem (2023) 256: 115458-115458 [PMID:37163950]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by 1536-well format based SYBR green assay F 6.8 pIC50 160 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 1536-well format based SYBR green assay F 6.8 pIC50 160 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A55 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.83 pIC50 149 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by pLDH assay F 6.83 pIC50 149 nM IC50 Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 8425 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.83 pIC50 148 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK144 F 6.84 pIC50 145.8 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfcrt gene F 6.85 pIC50 142 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK018 F 6.85 pIC50 141.1 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring 1 DDNHNDHHNND repeat F 6.85 pIC50 141 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by 96-well format based SYBR green assay F 6.85 pIC50 140 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H] hypoxanthine incorporation after 24 hrs by scintillation counting F 6.85 pIC50 140 nM IC50 Eur J Med Chem (2011) 46: 1897-1905 [PMID:21377771]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.86 pIC50 138 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.87 pIC50 135 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.87 pIC50 134 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay F 6.88 pIC50 133 nM IC50 Antimicrob Agents Chemother (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 8425 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.89 pIC50 130.3 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 1536-well format based SYBR green assay F 6.89 pIC50 130 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 1536-well format based SYBR green assay F 6.89 pIC50 130 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimicrobial activity against Plasmodium falciparum 3D7 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.89 pIC50 128 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 96-well format based SYBR green assay F 6.92 pIC50 120 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL In vitro inhibition of parasite development of Plasmodium falciparum W2 in human erythrocytes F 6.92 pIC50 120 nM IC50 Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.93 pIC50 118 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 F 6.95 pIC50 113 nM IC50 Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis F 6.95 pIC50 112 nM IC50 Medchemcomm (2011) 2: 430-435
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by 96-well format based SYBR green assay F 6.96 pIC50 110 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimalarial activity against Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 F 6.96 pIC50 110 nM IC50 Eur J Med Chem (2018) 146: 1-14 [PMID:29360043]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.96 pIC50 109 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs by lactate dehydrogenase assay F 6.97 pIC50 108 nM IC50 Eur J Med Chem (2021) 217: 113330-113330 [PMID:33744688]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 assessed as parasite growth inhibition incubated for 72 hrs by Malstat reagent based LDH assay F 6.97 pIC50 108 nM IC50 RSC Med Chem (2023) 14: 2768-2781 [PMID:38107179]
ChEMBL Antimicrobial activity against Plasmodium falciparum 3D7 harboring pfnhe1 ms4760 haplotype 2 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.97 pIC50 108 nM IC50 Antimicrob Agents Chemother (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA F 6.97 pIC50 106.9 nM IC50 Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay F 6.98 pIC50 105.68 nM IC50 Antimicrob Agents Chemother (2009) 53: 4040-4042 [PMID:19596882]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.98 pIC50 103.8 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Inhibitory concentration against Plasmodium falciparum W2 infected erythrocytes F 7 pIC50 100 nM IC50 J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by pLDH assay F 7.01 pIC50 96.8 nM IC50 Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes F 7.02 pIC50 96 nM IC50 Bioorg Med Chem Lett (2002) 12: 543-545 [PMID:11844668]
ChEMBL Antimicrobial activity against Plasmodium falciparum by ELISA F 7.03 pIC50 94.4 nM IC50 Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfmdr1 gene with 2 DNNND repeat F 7.04 pIC50 92 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK150 D-42 F 7.04 pIC50 91.6 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 16332 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 7.08 pIC50 83 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [G-3H]hypoxanthine uptake F 7.09 pIC50 81 nM IC50 Eur J Med Chem (2008) 43: 2840-2852 [PMID:18395298]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method F 7.09 pIC50 81 nM IC50 Med Chem Res (2007) 16: 213-229
ChEMBL Antimalarial activity against chloroquine sensitive Plasmodium falciparum HB3 after 72 hrs by SYBP Green I dye staining F 7.09 pIC50 81 nM IC50 Bioorg Med Chem (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 9067 F 7.1 pIC50 80.1 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 F 7.1 pIC50 80 nM IC50 Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 1536-well format based SYBR green assay F 7.1 pIC50 80 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 1536-well format based SYBR green assay F 7.1 pIC50 80 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 8885 F 7.11 pIC50 78.2 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against wild type Plasmodium falciparum HB3 infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay F 7.11 pIC50 77.13 nM IC50 Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by pLDH assay F 7.12 pIC50 75.3 nM IC50 Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL Antiplasmodial activity against CQ-susceptible Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of parasite growth measured after 72 hrs by HRP2-ELISA F 7.13 pIC50 74.2 nM IC50 Eur J Med Chem (2022) 228: 113981-113981 [PMID:34782182]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring pfmdr1-86 mutant gene F 7.13 pIC50 74 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against leupeptin resistant-Plasmodium falciparum HB3-leuR1 mutant infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay F 7.13 pIC50 73.96 nM IC50 Antimicrob Agents Chemother (2008) 52: 2346-2354 [PMID:18443109]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK183 F 7.13 pIC50 73.9 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by pLDH assay F 7.13 pIC50 73.5 nM IC50 Bioorg Med Chem Lett (2007) 17: 3599-3602 [PMID:17482816]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 6816 F 7.13 pIC50 73.3 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring SVMNT genotype after 72 hrs by SYBR green I assay F 7.15 pIC50 70 nM IC50 Antimicrob Agents Chemother (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay F 7.16 pIC50 69.19 nM IC50 Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL Growth inhibition of Plasmodium falciparum ring stage in infected erythrocytes by DAPI growth assay F 7.18 pIC50 66.52 nM IC50 Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring CVMNT genotype after 72 hrs by SYBR green I assay F 7.18 pIC50 66 nM IC50 Antimicrob Agents Chemother (2009) 53: 2042-2051 [PMID:19258269]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7A asexual forms assessed as inhibition of [G-3H]hypoxanthine uptake incubated for 24 hrs followed by [G-3H]hypoxanthine addition and measured after 18 hrs by liquid scintillation spectrometry F 7.18 pIC50 66 nM IC50 Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292]
ChEMBL Growth inhibition of Plasmodium falciparum as reduced [3H]hypoxanthine incorporation F 7.2 pIC50 62.77 nM IC50 Antimicrob Agents Chemother (2007) 51: 716-723 [PMID:17116676]
ChEMBL Antimicrobial activity against Plasmodium falciparum D6 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 7.21 pIC50 62 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum D6 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 7.21 pIC50 61.8 nM IC50 J Med Chem (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 in MSF assay F 7.22 pIC50 60 nM IC50 Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL Antimalarial activity against blood stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 72 hrs by SYBR green I fluorescence-based method F 7.24 pIC50 58 nM IC50 Bioorg Med Chem (2016) 24: 3527-3539 [PMID:27298002]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 10354 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 7.24 pIC50 58 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 9881 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 7.24 pIC50 57 nM IC50 Antimicrob Agents Chemother (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 8966 F 7.25 pIC50 55.8 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK033 D-49 F 7.27 pIC50 54.1 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum assessed as parasite growth inhibition after 48 hrs by [3H]hypoxanthin incorporation assay F 7.27 pIC50 53.7 nM IC50 Antimicrob Agents Chemother (2009) 53: 4588-4597 [PMID:19704124]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Inhibitory concentration against Plasmodium falciparum D6 infected erythrocytes F 7.32 pIC50 48 nM IC50 J Med Chem (1994) 37: 1486-1494 [PMID:8182707]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 7.32 pIC50 48 nM IC50 Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum harboring 3 DNNND repeat F 7.35 pIC50 45 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK022D-0 F 7.37 pIC50 42.4 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 9070 F 7.38 pIC50 41.5 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by 96-well format based SYBR green assay F 7.4 pIC50 40 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by 96-well format based SYBR green assay F 7.44 pIC50 36 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 8977 F 7.44 pIC50 35.9 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method F 7.47 pIC50 34 nM IC50 Med Chem Res (2007) 16: 213-229
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK033 D-0 F 7.48 pIC50 32.8 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by 96-well format based SYBR green assay F 7.51 pIC50 31 nM IC50 Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 8968 F 7.51 pIC50 30.6 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 8948 F 7.56 pIC50 27.8 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 F 7.57 pIC50 27.1 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs F 7.63 pIC50 23.38 nM IC50 J Nat Prod (1999) 62: 59-66 [PMID:9917283]
ChEMBL Antimalarial activity against CQ-sensitive Plasmodium falciparum NF54 F 7.66 pIC50 22 nM IC50 Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK022 D-28 F 7.66 pIC50 22 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial against chloroquine-rsistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting F 7.69 pIC50 20.4 nM IC50 Eur J Med Chem (2012) 57: 259-267 [PMID:23064162]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate 8973 F 7.7 pIC50 20 nM IC50 Antimicrob Agents Chemother (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial against chloroquine-rsistant Plasmodium falciparum W2 after 2 days by flow cytometry F 7.73 pIC50 18.7 nM IC50 Eur J Med Chem (2012) 57: 259-267 [PMID:23064162]
ChEMBL Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry F 7.73 pIC50 18.67 nM IC50 Eur J Med Chem (2014) 71: 128-134 [PMID:24287561]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay F 7.74 pIC50 18 nM IC50 Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL Antiplasmodial activity against CQ-sensitive Plasmodium falciparum 3D7 F 7.74 pIC50 18 nM IC50 Bioorg Med Chem (2015) 23: 5098-5119 [PMID:25593097]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay F 7.74 pIC50 18 nM IC50 Eur J Med Chem (2017) 139: 22-47 [PMID:28800458]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte incubated for 72 hrs by SYBR green I staining based fluorescence assay F 7.74 pIC50 18 nM IC50 Eur J Med Chem (2018) 146: 1-14 [PMID:29360043]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA F 7.81 pIC50 15.4 nM IC50 Antimicrob Agents Chemother (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimalarial activity against Plasmodium falciparum K1 F 7.92 pIC50 12 nM IC50 Eur J Med Chem (2009) 44: 2731-2735 [PMID:19084293]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 in MSF assay F 7.96 pIC50 11 nM IC50 Bioorg Med Chem (2008) 16: 1174-1183 [PMID:18023189]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.17 pIC50 6.7 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 8.24 pIC50 5.8 nM IC50 J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antiplasmodial against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs by scintillation counting F 9.15 pIC50 0.7 nM IC50 Eur J Med Chem (2012) 57: 259-267 [PMID:23064162]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay F 5.88 pEC50 1317 nM EC50 Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay F 6 pEC50 993 nM EC50 Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum FCR3 F 6.96 pEC50 110 nM EC50 Bioorg Med Chem Lett (2004) 14: 1689-1692 [PMID:15026051]
ChEMBL In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 F 6.96 pEC50 110 nM EC50 J Med Chem (2002) 45: 995-998 [PMID:11855978]
ChEMBL In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 F 6.96 pEC50 110 nM EC50 Bioorg Med Chem Lett (2000) 10: 1657-1659 [PMID:10937718]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR3 F 6.96 pEC50 110 nM EC50 Bioorg Med Chem Lett (2006) 16: 2758-2760 [PMID:16524728]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells F 4.64 pKi 22900 nM Ki J Pharmacol Exp Ther (1998) 286: 354-361 [PMID:9655880]
ChEMBL Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy B 4.29 pIC50 51600 nM IC50 J Med Chem (2008) 51: 5932-5942 [PMID:18788725]
Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes F 6.55 pIC50 280 nM IC50 Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells F 5.37 pKi 4300 nM Ki Naunyn Schmiedebergs Arch Pharmacol (1996) 354: 320-326 [PMID:8878062]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes F 6.03 pKi 930 nM Ki Nature (1994) 372: 549-552 [PMID:7990927]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes F 5.39 pIC50 4100 nM IC50 Am J Physiol Renal Physiol (2001) 281: F454-F468 [PMID:11502595]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells F 5.96 pIC50 1100 nM IC50 J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells F 6.05 pIC50 900 nM IC50 J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes F 5.47 pKi 3400 nM Ki DNA Cell Biol (1997) 16: 871-881 [PMID:9260930]
Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
ChEMBL TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes F 5.55 pIC50 2800 nM IC50 Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes F 4.26 pKi 55000 nM Ki Am J Physiol Renal Physiol (2001) 281: F454-F468 [PMID:11502595]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells F 4.42 pIC50 38000 nM IC50 J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
ChEMBL TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells F 4.89 pIC50 13000 nM IC50 J Pharmacol Exp Ther (2002) 303: 959-968 [PMID:12438515]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing LLC-PK1 cells F 4.12 pKi 76700 nM Ki Pharm Res (2002) 19: 147-153 [PMID:11883641]
Solute carrier organic anion transporter family member 1A4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
ChEMBL TP_TRANSPORTER: inhibition of Digoxin uptake in Oatp2-expressing LLC-PK1 cells F 5.42 pKi 3810 nM Ki Pharm Res (2002) 19: 147-153 [PMID:11883641]
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
GtoPdb - - 4.9 pIC50 - - - Am J Physiol (1998) 274: G901-11 [PMID:9612272]
Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
GtoPdb - - 4.57 pKi 26900 nM Ki Mol Pharmacol (2005) 68: 1397-407 [PMID:16099839];
Clin Pharmacol Ther (2016) 100: 489-499 [PMID:27506881]
Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
GtoPdb - - 6.86 pKi 138 nM Ki Sci Transl Med (2019) 11: [PMID:30602534]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]