quinine [Ligand Id: 2510] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL170 (NSC-192949, Quinine, WR297608)
  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • This target only has 1 pki data point
1 CHEMBL170_lig_chart_1 P-glycoprotein 1 Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
2 CHEMBL170_lig_chart_2 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922]
  • This target only has 0 pki data point
3 CHEMBL170_lig_chart_3 Plasmodium falciparum 3D7 Plasmodium falciparum 3D7
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
  • This target only has 0 pki data point
4 CHEMBL170_lig_chart_4 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
5 CHEMBL170_lig_chart_5 Solute carrier family 22 member 1 HumanMouseRat
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  • Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
  • Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
  • Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
6 CHEMBL170_lig_chart_6 Solute carrier family 22 member 2 HumanMouseRat
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  • Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
  • This target only has 1 pki data point
7 CHEMBL170_lig_chart_7 Solute carrier organic anion transporter family member 1A1 Rat
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  • Solute carrier organic anion transporter family member 1A4 in Rat [ChEMBL: CHEMBL1781860] [UniProtKB: O35913]
  • This target only has 1 pki data point
8 CHEMBL170_lig_chart_8 Solute carrier organic anion transporter family member 1A4 Rat
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  • Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
  • This target only has 0 pki data point
9 CHEMBL170_lig_chart_9 Kv2.2 Human
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  • Plasma membrane monoamine transporter in Human [GtoPdb: 1120] [UniProtKB: Q7RTT9]
  • This target only has 1 pki data point
10 CHEMBL170_lig_chart_10 Plasma membrane monoamine transporter Human
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  • Plasmodium falciparum purine nucleoside phosphorylase in Plasmodium falciparum [GtoPdb: 3077]
  • This target only has 1 pki data point
11 CHEMBL170_lig_chart_11 Plasmodium falciparum purine nucleoside phosphorylase Plasmodium falciparum
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model B 4.92 pKi 12000 nM Ki J. Med. Chem. (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells F 4.06 pIC50 87600 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
ChEMBL TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells F 4.13 pIC50 74400 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
ChEMBL TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells F 4.65 pIC50 22600 nM IC50 Biochem. Biophys. Res. Commun. (2001) 289: 580-585 [PMID:11716514]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.27 pIC50 54000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N40 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.67 pIC50 2123 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT K14 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 5.88 pIC50 1310 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.89 pIC50 1295 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.95 pIC50 1128 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B7 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.96 pIC50 1099 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis F 5.97 pIC50 1068 nM IC50 MedChemComm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 9996 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 5.98 pIC50 1039 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT K4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 5.99 pIC50 1034 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B2 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 5.99 pIC50 1016 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.01 pIC50 969 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.02 pIC50 953 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis F 6.04 pIC50 917 nM IC50 MedChemComm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N35 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.04 pIC50 905 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-46 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.05 pIC50 894 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B41 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.05 pIC50 886 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-3 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.06 pIC50 875 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-8 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.06 pIC50 874 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.06 pIC50 870 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N29 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.07 pIC50 853 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND repeat and His/Asp ratio 7:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.08 pIC50 837 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum after 48 hrs F 6.08 pIC50 826 nM IC50 Eur. J. Med. Chem. (2016) 112: 270-279 [PMID:26900659]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-35 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.09 pIC50 821 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B60 harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.12 pIC50 767 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 14 carrying 3 copies of DNNND repeat and His/Asp ratio 6:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.12 pIC50 767 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum ms4760-7 assessed as growth inhibition after 48 hrs by scintillation counting F 6.12 pIC50 764 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum W2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.14 pIC50 720 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A10 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.15 pIC50 716 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N66 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.15 pIC50 711 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042D 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.15 pIC50 710 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Bres infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.16 pIC50 688.7 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum W2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.16 pIC50 686 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.17 pIC50 683.9 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-58 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.17 pIC50 680 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.17 pIC50 670 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCR3 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.18 pIC50 665.3 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND repeat and His/Asp ratio 5:6 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.18 pIC50 661 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.19 pIC50 650 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-27 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.19 pIC50 650 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-11 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.2 pIC50 629 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum PA infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.2 pIC50 626.6 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum PA harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.2 pIC50 625 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K2 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.21 pIC50 619.4 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum 7G8 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034C 1042D 1246Y and pfcrt 72-76 SVMNT 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.21 pIC50 619 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against schizont stage of atovaquone-resistant Plasmodium falciparum Tm90C2b infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis F 6.22 pIC50 608 nM IC50 MedChemComm (2011) 2: 430-435
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.22 pIC50 607 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT A4 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.22 pIC50 605 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.22 pIC50 604 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum Dd2 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.22 pIC50 602 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT K2 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.22 pIC50 599 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against schizont stage of chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis F 6.23 pIC50 583 nM IC50 MedChemComm (2011) 2: 430-435
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B72 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.23 pIC50 583 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum ms4760-6 assessed as growth inhibition after 48 hrs by scintillation counting F 6.24 pIC50 582 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum FCM29 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.24 pIC50 580 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND repeat and His/Asp ratio 5:4 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.24 pIC50 580 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B63 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.24 pIC50 579 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT L1 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.24 pIC50 575 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-34 harboring pfnhe1 ms4760 haplotype 9 carrying 3 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.24 pIC50 574 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.24 pIC50 571 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.24 pIC50 571 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK127 F 6.24 pIC50 569.5 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A9 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.25 pIC50 562 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK182 F 6.26 pIC50 549.2 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum FCM29 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.26 pIC50 543.3 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.27 pIC50 543 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-6 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.27 pIC50 543 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.27 pIC50 543 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.27 pIC50 543 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.27 pIC50 538 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N22 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.27 pIC50 535 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum L1 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.27 pIC50 530.9 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N44 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.29 pIC50 514 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N78 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.29 pIC50 513 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-25 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.3 pIC50 502 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N72 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.3 pIC50 500 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT Bres harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.3 pIC50 500 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum K14 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.3 pIC50 495.5 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate AK227 F 6.31 pIC50 495.3 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA F 6.31 pIC50 490.8 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N33 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.31 pIC50 490 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N64 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.32 pIC50 475 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-28 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.33 pIC50 473 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F08B53 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.33 pIC50 468 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes 5,34 carrying4 copies of DNNND repeat and His/Asp ratio 5:8 infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.34 pIC50 462 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-7 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.34 pIC50 456 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 6311 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.34 pIC50 453 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09N58 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.35 pIC50 448 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-23 harboring pfnhe1 ms4760 haplotype 1 carrying 2 copies of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.35 pIC50 447 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-31 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.36 pIC50 433 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35 F 6.37 pIC50 431 nM IC50 Eur. J. Med. Chem. (2015) 94: 56-62 [PMID:25747499]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.37 pIC50 428 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.37 pIC50 428 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-56 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.37 pIC50 427 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum Voll infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine uptake after 48 hrs F 6.37 pIC50 421.7 nM IC50 J. Med. Chem. (2010) 53: 3214-3226 [PMID:20329733]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT Vol harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.38 pIC50 421 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 Indochina by [3H]hypoxanthine uptake F 6.38 pIC50 413 nM IC50 J. Nat. Prod. (2001) 64: 12-16 [PMID:11170658]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake F 6.38 pIC50 413 nM IC50 J. Nat. Prod. (2002) 65: 1381-1386 [PMID:12398531]
ChEMBL Antimicrobial activity against Plasmodium falciparum K1 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86Y 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.39 pIC50 407 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-42 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.41 pIC50 388 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Inhibitory concentration against multidrug-resistant Plasmodium falciparum Dd2. F 6.42 pIC50 380 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 2681-2683 [PMID:12217353]
ChEMBL Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay F 6.42 pIC50 380 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes F 6.42 pIC50 380 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668]
ChEMBL Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes F 6.42 pIC50 380 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 423-424 [PMID:11212126]
ChEMBL Antimicrobial activity against Plasmodium falciparum F09A61 harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.43 pIC50 373 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum IMT 31 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.43 pIC50 371 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimicrobial activity against Plasmodium falciparum Feng harboring pfnhe1 ms4760 haplotype 7 carrying 3 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.43 pIC50 371 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake F 6.43 pIC50 370 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-13 harboring pfnhe1 ms4760 haplotype 3 carrying 1 copy of DNNND and 2 copies of NHNDNHNNDDD repeats, pfmdr1 86N 184Y 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.44 pIC50 365 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimicrobial activity against Plasmodium falciparum FCR3 harboring Pfcrt, Pfmdr1, Pfmrp, and Pfnhe-1 polymorphisms assessed as growth inhibition after 48 hrs by scintillation counting F 6.48 pIC50 334 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1926-1930 [PMID:19273668]
ChEMBL Antimalarial activity against Plasmodium falciparum isolate CDA-1553 F 6.48 pIC50 333.3 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-47 harboring pfnhe1 ms4760 haplotype 20 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.49 pIC50 324 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.49 pIC50 322 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimicrobial activity against Plasmodium falciparum F07-9 harboring pfnhe1 ms4760 haplotype 6 carrying 2 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042N 1246D and pfcrt 72-76 CVIET 220S infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.49 pIC50 321 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by 1536-well format based SYBR green assay F 6.49 pIC50 320 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining F 6.49 pIC50 320 nM IC50 Bioorg. Med. Chem. (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL Antimicrobial activity against Plasmodium falciparum HB3 harboring pfnhe1 ms4760 haplotype 5 carrying 4 copies of DNNND and 1 copy of NHNDNHNNDDD repeats, pfmdr1 86N 184F 1034S 1042D 1246D and pfcrt 72-76 CVMNK 220A infected in human erythrocytes after 72 hrs by SYBR green I-based fluorescence assay F 6.5 pIC50 319 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 4306-4313 [PMID:20643902]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 6.5 pIC50 314 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 6.5 pIC50 314 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring pfnhe1 ms4760 haplotypes1,18 carrying 2 copies of DNNND repeat and His/Asp ratio 7:4 infected in human erythrocytes after 72 hrs by SYBR green I-