artemotil [Ligand Id: 9958] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL301267 (Arteether, Artemotil, Artemotilum, .beta.-arteether, NSC-665971)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone) F 8.39 pIC50 4.07 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Inhibitory concentration against Plasmodium falciparum W2 Indochina F 8.53 pIC50 2.94 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 F 8.57 pIC50 2.7 nM IC50 J. Med. Chem. (2000) 43: 2753-2758 [PMID:10893313]
ChEMBL In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum African D6 F 8.57 pIC50 2.7 nM IC50 J. Med. Chem. (2002) 45: 3331-3336 [PMID:12139444]
ChEMBL Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS F 8.59 pIC50 2.58 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS F 8.66 pIC50 2.18 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 F 8.85 pIC50 1.4 nM IC50 J. Med. Chem. (2000) 43: 2753-2758 [PMID:10893313]
ChEMBL In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina F 8.85 pIC50 1.4 nM IC50 J. Med. Chem. (2002) 45: 3331-3336 [PMID:12139444]
ChEMBL Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay F 8.86 pIC50 1.37 nM IC50 J. Med. Chem. (2013) 56: 31-45 [PMID:23270565]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green I-based fluorescence assay F 8.97 pIC50 1.08 nM IC50 J. Med. Chem. (2013) 56: 31-45 [PMID:23270565]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]