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ChEMBL ligand: CHEMBL301267 (Arteether, Artemotil, Artemotilum, .beta.-arteether, NSC-665971) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone) | F | 8.39 | pIC50 | 4.07 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Inhibitory concentration against Plasmodium falciparum W2 Indochina | F | 8.53 | pIC50 | 2.94 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum African D6 | F | 8.57 | pIC50 | 2.7 | nM | IC50 | J Med Chem (2002) 45: 3331-3336 [PMID:12139444] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | F | 8.57 | pIC50 | 2.7 | nM | IC50 | J Med Chem (2000) 43: 2753-2758 [PMID:10893313] |
ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS | F | 8.59 | pIC50 | 2.58 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS | F | 8.66 | pIC50 | 2.18 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2000) 43: 2753-2758 [PMID:10893313] |
ChEMBL | In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina | F | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2002) 45: 3331-3336 [PMID:12139444] |
ChEMBL | Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay | F | 8.86 | pIC50 | 1.37 | nM | IC50 | J Med Chem (2013) 56: 31-45 [PMID:23270565] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green I-based fluorescence assay | F | 8.97 | pIC50 | 1.08 | nM | IC50 | J Med Chem (2013) 56: 31-45 [PMID:23270565] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]