artemotil [Ligand Id: 9958] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL301267 (Arteether, Artemotil, Artemotilum, .beta.-arteether, NSC-665971) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone) | F | 8.39 | pIC50 | 4.07 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Inhibitory concentration against Plasmodium falciparum W2 Indochina | F | 8.53 | pIC50 | 2.94 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 | F | 8.57 | pIC50 | 2.7 | nM | IC50 | J Med Chem (2000) 43: 2753-2758 [PMID:10893313] |
| ChEMBL | In vitro inhibitory activity against chloroquine-sensitive Plasmodium falciparum African D6 | F | 8.57 | pIC50 | 2.7 | nM | IC50 | J Med Chem (2002) 45: 3331-3336 [PMID:12139444] |
| ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS | F | 8.59 | pIC50 | 2.58 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS | F | 8.66 | pIC50 | 2.18 | nM | IC50 | J Med Chem (1988) 31: 645-650 [PMID:3279208] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 | F | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2000) 43: 2753-2758 [PMID:10893313] |
| ChEMBL | In vitro inhibitory activity against chloroquine-resistant Plasmodium falciparum W2 Indochina | F | 8.85 | pIC50 | 1.4 | nM | IC50 | J Med Chem (2002) 45: 3331-3336 [PMID:12139444] |
| ChEMBL | Antimalarial activity against schizont stage of chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay | F | 8.86 | pIC50 | 1.37 | nM | IC50 | J Med Chem (2013) 56: 31-45 [PMID:23270565] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR Green I-based fluorescence assay | F | 8.97 | pIC50 | 1.08 | nM | IC50 | J Med Chem (2013) 56: 31-45 [PMID:23270565] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
