OSM-S-38 [Ligand Id: 9708] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2113938 (OSM-S-38)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. Dose response curves were generated comprising of 8 points using a 2-fold serial dilution for the maximum final concentration of 1000 nM. Ralph Group, Bio21. F 6.69 pIC50 205 nM IC50 Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. GSK Tres Cantos. F 7.54 pIC50 29 nM IC50 Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL OSM: Late stage gametocytes. IC50 values determined from 21 point dose response curves. Avery Group Griffith. F 8.4 pIC50 4 nM IC50 Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL OSM: Inhibition of Plasmodium falciparum 3D7 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith. F 8.7 pIC50 2 nM IC50 Open Source Malaria Deposition 1. http://malaria.ourexperiment.org

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]